Hydroxypropyl Methylcellulose (HPMC) yog ib qho semi-synthetic, inert, high-viscosity polymer dav siv hauv cov tshuaj formulations. Nws cov khoom tshwj xeeb ntawm lub cev thiab tshuaj lom neeg ua rau nws yog ib qho tseem ceeb hauv kev lag luam kws tshuaj, nrog rau kev ua yeeb yaj kiab, thickening, stability thiab biocompatibility.
Cov yam ntxwv tseem ceeb ntawm HPMC
HPMC yog tsim los ntawm methylating thiab hydroxypropylating cellulose. Nws muaj cov dej zoo solubility thiab thermoplasticity, thiab yaj sai sai hauv dej txias los tsim cov pob tshab colloidal tov. Nws cov solubility thiab viscosity tuaj yeem tswj tau los ntawm kev kho cov degree ntawm kev hloov pauv thiab degree ntawm polymerization, uas tso cai rau HPMC kom tau raws li qhov xav tau ntawm cov tshuaj sib txawv.
Cov chaw thov
1. Tswj-tso tshuaj
HPMC yog siv dav hauv kev npaj cov tshuaj tswj-tso tawm. Vim nws solubility hauv dej thiab muaj peev xwm tsim cov gels, HPMC tuaj yeem tswj cov tshuaj tso tawm. Nws cov khoom o hauv plab hnyuv tso cai rau cov tshuaj maj mam tso tawm hauv lub sijhawm tshwj xeeb, tswj cov ntshav plasma concentration ntawm cov tshuaj, txo qhov zaus ntawm cov tshuaj, thiab txhim kho cov neeg mob ua raws.
2. Binders thiab disintegrants rau cov ntsiav tshuaj
Raws li kev sib khi thiab tsis sib haum rau cov ntsiav tshuaj, HPMC tuaj yeem txhim kho lub zog ntawm cov ntsiav tshuaj thaum ua kom cov ntsiav tshuaj tawg thiab tso tawm cov khoom xyaw nquag hauv lub sijhawm tsim nyog. Nws cov khoom nplaum pab khi cov tshuaj ua ke los tsim cov ntsiav tshuaj muaj zog, thaum nws cov khoom o tuaj yeem tso cai rau cov ntsiav tshuaj kom tawg sai sai hauv dej.
3. Cov neeg ua yeeb yaj kiab txheej
HPMC yog ib yam khoom tseem ceeb rau kev npaj tshuaj yeeb yaj kiab txheej. Nws tuaj yeem siv los ua cov txheej txheem tiv thaiv zaj duab xis los tiv thaiv cov tshuaj los ntawm ya raws, oxygen thiab lub teeb, yog li kev txhim kho kev ruaj ntseg ntawm cov tshuaj. Tsis tas li ntawd, HPMC tseem tuaj yeem siv los ua cov txheej txheej enteric los tiv thaiv cov tshuaj los ntawm kev tso tawm hauv plab thiab xyuas kom meej tias cov tshuaj tau nqus hauv cov hnyuv.
4. Kev npaj kho qhov muag
Hauv kev npaj kho qhov muag, HPMC feem ntau yog siv los npaj cov kua muag cuav thiab qhov muag tee. Nws cov viscosity siab thiab biocompatibility ua rau nws tsim cov yeeb yaj kiab tiv thaiv ntawm qhov muag, lubricate lub qhov muag, thiab txo cov tsos mob ntawm qhov muag qhuav.
5. Capsules
HPMC tuaj yeem siv los npaj cov tshuaj ntsiav thiab cov tshuaj ntsiav mos. Piv nrog rau cov tshuaj ntsiav tshuaj gelatin, HPMC capsules muaj cov tshuaj zoo dua qub, tsis yooj yim rau nqus dej, thiab muaj kev phooj ywg ntau dua rau cov neeg tsis noj nqaij thiab cov ntseeg kev ntseeg.
Kev cuam tshuam
1. Viscosity
Lub viscosity ntawm HPMC yog ib qho ntawm cov cim tseem ceeb ntawm nws qhov kev ua tau zoo. High-viscosity HPMC tuaj yeem siv rau kev tswj-tso tshuaj thiab kev npaj ua yeeb yaj kiab, thaum tsis tshua muaj viscosity HPMC yog qhov tsim nyog rau kev siv los ua ib qho kev sib khi thiab tsis sib xws.
2. Kev hloov pauv
Qhov degree ntawm kev hloov pauv (DS) thiab molar hloov pauv (MS) ntawm HPMC ncaj qha cuam tshuam rau nws cov dej solubility thiab gel-forming peev xwm. Kev kho kom haum ntawm qib kev hloov pauv tuaj yeem ua kom zoo dua qhov kev thov ntawm HPMC hauv cov tshuaj sib txawv.
3. Cov xwm txheej ib puag ncig
Kev ua haujlwm ntawm HPMC tseem cuam tshuam los ntawm ib puag ncig yam xws li kub, pH tus nqi thiab lub zog ionic. Cov xwm txheej no yuav tsum tau txiav txim siab thaum npaj cov tshuaj kho mob kom ntseeg tau tias HPMC ua tau zoo.
Hydroxypropyl methylcellulose (HPMC), raws li ib tug multifunctional, high-kev ua tau zoo kws tshuaj excipient, yog dav siv nyob rau hauv ntau yam xws li tshuaj tswj kev tso tawm, ntsiav tshuaj, film-coated npaj, ophthalmic npaj thiab tsiav tshuaj. Los ntawm kev kho nws cov viscosity thiab qib ntawm kev hloov pauv, nws tuaj yeem ua tau raws li qhov xav tau ntawm cov tshuaj sib txawv thiab txhim kho qhov ruaj khov thiab bioavailability ntawm cov tshuaj. Nrog rau kev nce qib ntawm kev siv tshuaj tsis tu ncua, daim ntawv thov kev cia siab ntawm HPMC yuav dav dua.
Post lub sij hawm: Lub Xya hli ntuj-11-2024