Hydroxypropyl cellulose, ib tug kws tshuaj excipient, muab faib mus rau hauv low-substituted hydroxypropyl cellulose (L-HPC) thiab high-substituted hydroxypropyl cellulose (H-HPC) raws li cov ntsiab lus ntawm nws substituent hydroxypropyl cellulose. L-HPC swells rau hauv cov tshuaj colloidal hauv dej, muaj cov khoom ntawm adhesion, tsim zaj duab xis, emulsification, thiab lwm yam, thiab feem ntau yog siv los ua tus neeg sawv cev disintegrating thiab binder; Thaum H-HPC yog soluble nyob rau hauv dej thiab ntau yam organic solvents ntawm chav tsev kub, thiab muaj zoo thermoplasticity. , cohesiveness thiab zaj duab xis-forming zog, cov zaj duab xis tsim yog ib qho nyuaj, glossy, thiab tag nrho elastic, thiab yog tsuas yog siv raws li ib tug zaj duab xis-forming khoom thiab txheej txheej. Daim ntawv thov tshwj xeeb ntawm hydroxypropyl cellulose hauv cov khoom npaj tam sim no tau qhia.
1. Ua ib qho disintegrant rau cov khoom npaj xws li ntsiav tshuaj
Qhov saum npoo ntawm low-substitutedhydroxypropyl cellulosecrystalline hais tsis sib xws, nrog pom tseeb weathered pob zeb zoo li qauv. Cov qauv saum npoo ntawm qhov ntxhib no tsis tsuas yog ua rau nws muaj thaj chaw loj dua, tab sis kuj thaum nws tau ntim rau hauv cov ntsiav tshuaj ua ke nrog cov tshuaj thiab lwm yam khoom siv, ntau qhov pores thiab capillaries tau tsim nyob rau hauv cov ntsiav tshuaj core, kom cov ntsiav tshuaj tuaj yeem ua kom cov dej noo. absorption tus nqi thiab dej nqus dej nce o. Siv L-HPC ua ib qho khoom noj tuaj yeem ua rau cov ntsiav tshuaj sai sai rau hauv cov hmoov sib tov, thiab txhim kho qhov kev sib cais, kev sib cais thiab bioavailability ntawm cov ntsiav tshuaj. Piv txwv li, kev siv L-HPC tuaj yeem ua kom nrawm nrawm ntawm cov ntsiav tshuaj paracetamol, cov tshuaj aspirin, thiab cov ntsiav tshuaj chlorpheniramine, thiab txhim kho qhov kev sib cais. Kev sib cais thiab kev sib cais ntawm cov tshuaj tsis zoo soluble xws li cov ntsiav tshuaj ofloxacin nrog L-HPC raws li cov tshuaj disintegrants tau zoo dua li cov uas muaj kev sib txuas ntawm PVPP, cross-linked CMC-Na thiab CMS-Na ua disintegrants. Kev siv L-HPC ua ib qho kev sib cais sab hauv ntawm cov granules hauv cov tshuaj ntsiav muaj txiaj ntsig zoo rau kev tawg ntawm cov granules, ua rau thaj chaw sib cuag ntawm cov tshuaj thiab qhov nruab nrab dissolution, txhawb kev sib cais ntawm cov tshuaj, thiab txhim kho bioavailability. Tam sim no-tso cov khoom npaj uas sawv cev los ntawm cov khoom npaj sai-disintegrating thiab instant-dissolving khoom npaj muaj ceev-disintegrating, instant-dissolving, sai-acting teebmeem, siab bioavailability, txo cov tshuaj irritation rau txoj hlab pas thiab gastrointestinal ib ntsuj av, thiab yog yooj yim mus noj. thiab muaj kev ua tau zoo. thiab lwm yam zoo, tuav txoj haujlwm tseem ceeb hauv kev lag luam tshuaj. L-HPC tau dhau los ua ib qho tseem ceeb tshaj plaws excipients rau tam sim-tso khoom npaj vim nws muaj zog hydrophilicity, hygroscopicity, expansibility, luv hysteresis lub sij hawm rau dej nqus, ceev dej nqus ceev, thiab ceev dej nqus saturation. Nws yog ib qho zoo tagnrho disintegrant rau qhov ncauj disintegrating ntsiav tshuaj. Paracetamol qhov ncauj disintegrating ntsiav tshuaj tau npaj nrog L-HPC li disintegrant, thiab cov ntsiav tshuaj disintegrated sai nyob rau hauv 20s. L-HPC yog siv los ua disintegrant rau cov ntsiav tshuaj, thiab nws cov koob tshuaj yog 2% mus rau 10%, feem ntau 5%.
2. Raws li ib tug binder rau kev npaj xws li ntsiav tshuaj thiab granules
Cov qauv ntxhib ntawm L-HPC kuj ua rau nws muaj cov nyhuv mosaic ntau dua nrog cov tshuaj thiab cov khoom, uas ua rau kom muaj kev sib koom ua ke, thiab muaj kev ua haujlwm zoo compression molding. Tom qab raug nias rau hauv cov ntsiav tshuaj, nws qhia tau hais tias hardness thiab gloss, yog li txhim kho qhov zoo ntawm cov ntsiav tshuaj cov tsos. Tshwj xeeb tshaj yog rau cov ntsiav tshuaj uas tsis yooj yim rau kev tsim, xoob lossis yooj yim rau kev nthuav tawm, ntxiv L-HPC tuaj yeem txhim kho cov nyhuv. Cov ntsiav tshuaj ciprofloxacin hydrochloride muaj qhov tsis zoo compressibility, yooj yim rau kev sib cais thiab nplaum, thiab nws yog ib qho yooj yim rau tsim tom qab ntxiv L-HPC, nrog rau qhov tsim nyog hardness, zoo nkauj tsos, thiab dissolution tus nqi raws li tus qauv zoo. Tom qab ntxiv L-HPC rau hauv cov ntsiav tshuaj dispersible, nws cov tsos, friability, dispersion uniformity thiab lwm yam zoo heev thiab txhim kho. Tom qab cov hmoov txhuv nplej siab nyob rau hauv thawj cov tshuaj tau hloov los ntawm L-HPC, lub hardness ntawm cov ntsiav tshuaj azithromycin dispersible tau nce, lub friability tau zoo tuaj, thiab cov teeb meem ntawm cov ces kaum uas ploj lawm thiab rotten npoo ntawm cov thawj ntsiav tshuaj tau daws. L-HPC yog siv los ua cov ntawv khi rau cov ntsiav tshuaj, thiab qhov ntau npaum li cas yog 5% txog 20%; thaum H-HPC yog siv los ua cov ntawv khi rau cov ntsiav tshuaj, granules, thiab lwm yam, thiab qhov ntau npaum li cas yog 1% mus rau 5% ntawm kev npaj.
3. Daim ntawv thov nyob rau hauv zaj duab xis txheej thiab sustained thiab tswj kev tso tawm npaj
Tam sim no, cov ntaub ntawv dej-soluble feem ntau siv hauv zaj duab xis txheej xws li hydroxypropylmethylcellulose (HPMC), hydroxypropylcellulose, polyethylene glycol (PEG) thiab lwm yam. Hydroxypropyl cellulose feem ntau yog siv los ua cov yeeb yaj kiab tsim hauv zaj duab xis txheej premixing cov ntaub ntawv vim nws tawv, elastic thiab glossy zaj duab xis. Yog tias hydroxypropyl cellulose sib xyaw nrog lwm cov tshuaj tiv thaiv kub-tiv taus, kev ua haujlwm ntawm nws cov txheej tuaj yeem txhim kho ntxiv.
Siv cov txheej txheem tsim nyog thiab cov txheej txheem los ua cov tshuaj rau hauv cov ntsiav tshuaj matrix, cov ntsiav tshuaj hauv plab, cov ntsiav tshuaj ntau txheej, cov ntsiav tshuaj coated, osmotic cov ntsiav tshuaj twj tso kua mis thiab lwm yam qeeb thiab tswj cov ntsiav tshuaj tso tawm, qhov tseem ceeb nyob hauv: nce qib ntawm kev nqus tshuaj thiab stabilizing cov tshuaj. tshuaj nyob rau hauv cov ntshav. Concentration, txo qhov tsis zoo tshwm sim, txo tus naj npawb ntawm cov tshuaj, thiab siv zog ua kom cov nyhuv curative nrog rau qhov tsawg tshaj plaws, thiab txo qis qhov tsis zoo tshwm sim. Hydroxypropyl cellulose yog ib qho ntawm cov khoom tseem ceeb ntawm cov tshuaj no. Kev tawg thiab tso tawm ntawm cov ntsiav tshuaj diclofenac sodium yog tswj los ntawm kev siv hydroxypropyl cellulose thiab ethyl cellulose ua cov khoom sib koom ua ke thiab cov pob txha. Tom qab kev tswj hwm qhov ncauj thiab kev sib cuag nrog cov kua txiv hmab txiv ntoo, qhov chaw ntawm diclofenac sodium sustained-tso ntsiav tshuaj yuav hydrated rau hauv gel. Los ntawm kev sib cais ntawm cov gel thiab diffusion ntawm cov tshuaj molecules nyob rau hauv qhov sib txawv gel, lub hom phiaj ntawm kev tso tawm qeeb ntawm cov tshuaj molecules tiav. Hydroxypropyl cellulose yog siv raws li Kev Tswj-tso tawm matrix ntawm cov ntsiav tshuaj, thaum cov ntsiab lus ntawm blocker ethyl cellulose yog tas li, nws cov ntsiab lus hauv cov ntsiav tshuaj ncaj qha txiav txim siab qhov tso tawm ntawm cov tshuaj, thiab cov tshuaj los ntawm cov ntsiav tshuaj nrog cov ntsiab lus siab dua. ntawm hydroxypropyl cellulose Tso tawm qeeb dua. Cov coated pellets tau npaj los ntawm kev siv L-HPC thiab ib qho kev faib ua feem ntawm HPMC raws li cov txheej txheem rau txheej txheej o, thiab raws li cov txheej txheem tswj-tso rau txheej txheej nrog ethyl cellulose aqueous dispersion. Thaum cov txheej txheem o thiab ntau npaum li cas raug kho, los ntawm kev tswj cov tuab ntawm cov txheej txheem tso tawm, cov pellets coated tuaj yeem tso tawm ntawm lub sijhawm sib txawv. Ntau hom coated pellets nrog qhov sib txawv qhov hnyav nce ntawm cov txheej txheem tso tawm yog sib xyaw ua rau Shuxiong sustained-tso capsules. Nyob rau hauv qhov nruab nrab dissolution, ntau yam coated pellets tuaj yeem tso cov tshuaj sib txuas ntawm lub sijhawm sib txawv, kom cov khoom sib txawv ntawm lub cev thiab tshuaj lom neeg ib txhij tso tawm tiav tib lub sijhawm raws li kev tso tawm.
Post lub sij hawm: Dec-28-2022