1. Taw qhia rau HPMC
Hydroxypropyl Methylcellulose (HPMC) yog non-ionic cellulose ether siv dav hauv cov khoom siv hauv tsev, txheej, tshuaj, tshuaj pleev ib ce, zaub mov thiab lwm yam haujlwm. Vim nws cov dej zoo solubility, gelling thiab thickening zog, HPMC feem ntau yog siv los ua thickener, stabilizer thiab gelling tus neeg sawv cev. Cov dej solubility ntawm HPMC yog ib qho ntawm nws cov khoom tseem ceeb hauv kev siv tswv yim, tab sis nws lub sij hawm tawg nws txawv vim muaj ntau yam.
2. Cov txheej txheem tawg ntawm HPMC
HPMC muaj dej solubility zoo, tab sis thaum lub sij hawm dissolution txheej txheem, nws yuav tsum tau nqus dej thiab o ua ntej, thiab ces maj mam yaj. Cov txheej txheem no feem ntau muab faib ua cov theem hauv qab no:
Kev nqus dej thiab o: HPMC thawj zaug nqus dej hauv dej, thiab cellulose molecules pib o.
Dispersion mixing: HPMC yog sib npaug zos rau hauv dej los ntawm stirring los yog lwm yam mechanical txhais tau tias kom tsis txhob agglomeration.
Dissolution los tsim ib qho kev daws teeb meem: Nyob rau hauv cov xwm txheej tsim nyog, HPMC molecules maj mam tshem tawm thiab yaj hauv dej los tsim cov tshuaj colloidal ruaj khov.
3. Lub sijhawm tawg ntawm HPMC
Lub sijhawm tawg ntawm HPMC tsis raug kho, feem ntau yog li ntawm 15 feeb mus rau ob peb teev, thiab lub sijhawm tshwj xeeb yog nyob ntawm cov hauv qab no:
Hom thiab viscosity qib ntawm HPMC: Qhov hnyav molecular thiab qib viscosity ntawm HPMC muaj qhov cuam tshuam loj rau lub sijhawm tawg. HPMC nrog viscosity siab yuav siv sij hawm ntev kom yaj, thaum HPMC uas tsis muaj viscosity dissolves sai. Piv txwv li, 4000 cps HPMC yuav siv sij hawm ntev kom yaj, thaum 50 cps HPMC yuav yaj tag hauv li 15 feeb.
Dej kub: Kub yog ib qho tseem ceeb cuam tshuam rau lub sij hawm dissolution ntawm HPMC. Feem ntau hais lus, HPMC yuav nqus dej thiab o sai sai hauv dej txias, tab sis yaj maj mam; hauv dej kub (xws li saum 60°C), HPMC yuav tsim ib lub xeev insoluble ib ntus. Yog li ntawd, "cov dej txias thiab dej kub ob txoj kev sib cais" ntawm thawj dispersing nrog dej txias thiab tom qab ntawd cua sov feem ntau yog siv los ua kom cov txheej txheem tawg.
Txoj Kev Txiav Txim Siab: Txoj kev sib cais kuj tseem muaj txiaj ntsig zoo rau lub sijhawm sib cais ntawm HPMC. Cov txheej txheem sib cais feem ntau suav nrog cov tshuab nplawm, kev kho ultrasonic lossis kev siv cov cuab yeej ua haujlwm siab ceev. Cov neeg kho tshuab nplawm tuaj yeem ua kom muaj qhov sib xyaw ua kom zoo, tab sis yog tias nws tsis ua haujlwm zoo, nws tuaj yeem tsim cov pob thiab cuam tshuam rau kev ua kom tawg. Kev siv lub tshuab ua kom siab ceev lossis homogenizer tuaj yeem txo lub sijhawm tawg.
HPMC particle loj: Qhov me me ntawm cov khoom, qhov kev sib cais sai dua. Cov particle HPMC yog yooj yim rau disperse thiab yaj tusyees, thiab feem ntau yog siv nyob rau hauv daim ntawv thov scenarios nrog siab dissolution tus nqi yuav tsum tau.
Cov kuab tshuaj nruab nrab: Txawm hais tias HPMC feem ntau yog soluble hauv dej, nws tseem tuaj yeem yaj hauv qee cov kuab tshuaj organic, xws li ethanol thiab propylene glycol aqueous daws. Cov tshuab hnyav sib txawv yuav cuam tshuam rau tus nqi tawg. Rau cov kuab tshuaj organic, lub sij hawm tawg feem ntau ntev dua li hauv dej.
4. Cov teeb meem tshwm sim hauv cov txheej txheem kev tshem tawm ntawm HPMC
agglomeration phenomenon: HPMC yog nquag tsim cov pob thaum yaj hauv dej, tshwj xeeb tshaj yog thaum cov dej kub siab los yog cov stirring tsis txaus. Qhov no yog vim tias qhov chaw ntawm HPMC nqus dej thiab nthuav dav sai, thiab sab hauv tseem tsis tau tiv nrog dej, ua rau qeeb qeeb ntawm cov khoom siv sab hauv. Yog li ntawd, hauv kev ua haujlwm tiag tiag, nws feem ntau yog siv los maj mam thiab sib npaug sib npaug HPMC rau hauv dej txias ua ntej, thiab do kom tsim nyog los tiv thaiv agglomeration.
Kev puas tsuaj tsis tiav: Qee zaum cov tshuaj HPMC zoo li tsis sib xws, tab sis qhov tseeb ib feem ntawm cellulose tsis yaj tag. Lub sijhawm no, nws yog ib qho tsim nyog los txuas ntxiv lub sijhawm nplawm, lossis txhawb kev sib cais los ntawm kev tswj qhov kub thiab txias thiab cov cuab yeej siv tshuab.
5. Yuav ua li cas rau optimize lub sij hawm dissolution ntawm HPMC
Siv cov dej txias dispersion txoj kev: maj mam sprinkle HPMC rau hauv dej txias kom tsis txhob agglomeration los ntawm instantaneous dej nqus thiab nthuav. Tom qab HPMC tau tawg tag, ua kom sov rau 40-60°C los txhawb kev ua kom tiav ntawm HPMC.
Xaiv cov khoom siv stirring: rau scentres nrog kev sib cais ceev, koj tuaj yeem xaiv siv cov khoom siv nrawm nrawm thiab ua tau zoo thiab ua kom lub sijhawm ua kom luv.
Kev tswj qhov kub thiab txias: Kev tswj qhov kub thiab txias yog tus yuam sij rau dissolving HPMC. Tsis txhob siv cov dej kub uas muaj qhov kub thiab txias heev kom yaj HPMC ncaj qha, tab sis siv cov dej txias dispersion thiab ces cua sov. Rau qhov sib txawv daim ntawv thov scenarios, koj muaj peev xwm xaiv qhov tsim nyog dissolution kub raws li koj xav tau kev pab.
Lub sijhawm tawg ntawm HPMC yog cov txheej txheem dynamic cuam tshuam los ntawm ntau yam. Feem ntau hais lus, lub sij hawm tawg ntawm 15 feeb mus rau ob peb teev yog qhov qub, tab sis lub sij hawm tawg tuaj yeem ua kom luv luv los ntawm kev ua kom zoo rau txoj kev sib cais, nplawm ceev, particle loj thiab tswj kub.
Post lub sij hawm: Oct-25-2024