Hydroxypropylmethylcellulose (HPMC) yog ib qho khoom siv hauv kev lag luam tshuaj thiab zaub mov. Nws yog dej-soluble polymer tau los ntawm kev hloov kho cellulose. HPMC muaj cov khoom sib txawv xws li kev tsim cov yeeb yaj kiab, thickening thiab khi, uas ua rau nws muaj qhov tseem ceeb hauv ntau yam kev siv.
Ib qho ntawm cov khoom tseem ceeb ntawm HPMC yog nws lub peev xwm ua yeeb yaj kiab. HPMC tsim cov yeeb yaj kiab ruaj khov thaum sib cuag nrog dej, uas pab txhawb kev tsim cov ntsiav tshuaj thiab tshuaj ntsiav. Cov khoom ua yeeb yaj kiab ntawm HPMC ua kom cov tshuaj tso tawm ntawm tus nqi tswj, ua rau nws zoo tagnrho rau kev tswj-tso formulations. Tsis tas li ntawd, cov yeeb yaj kiab tsim cov khoom ntawm HPMC tiv thaiv cov tshuaj degradation los ntawm ib puag ncig yam xws li ya raws thiab oxygen.
Lwm yam khoom tseem ceeb ntawm HPMC yog nws lub peev xwm thickening. HPMC muaj peev xwm ua kom cov viscosity ntawm cov kua los ntawm kev txhim kho kev ncua thiab emulsifying zog. Cov cuab yeej no ua rau nws muaj cov khoom tseem ceeb hauv ntau yam khoom noj xws li kua ntses, hnav khaub ncaws thiab khoom noj khoom haus.
Ib yam li ntawd, HPMC muaj lub peev xwm zoo sib xws, uas yog qhov tseem ceeb rau cov ntsiav tshuaj compression thiab granulation. Cov khoom nplaum ntawm HPMC xyuas kom meej tias cov ntsiav tshuaj tsis tawg yooj yim thiab cov tshuaj raug tso tawm ntawm nws qhov chaw ua haujlwm. Cov cuab yeej no ntawm HPMC kuj tseem siv rau hauv kev tsim cov ntsiav tshuaj hauv qhov ncauj, qhov chaw uas nws ua raws li kev khi thiab txhim kho kev sib cais thiab kev sib cais ntawm cov tshuaj.
Cov khoom ntawm HPMC ua rau nws yog ib qho tseem ceeb muaj nyob rau hauv ntau yam kev siv, tab sis nws qhov zoo thiab kev ua tau zoo yuav tsum raug kuaj kom ntseeg tau tias cov khoom muaj kev nyab xeeb thiab ua tau zoo. Kev ntsuas kev tswj hwm zoo rau HPMC suav nrog kev sim ntau yam ntawm lub cev thiab tshuaj lom neeg xws li particle loj, viscosity thiab noo noo cov ntsiab lus.
Particle loj tsom xam yog qhov tseem ceeb rau tus yam ntxwv ntawm HPMCs thiab feem ntau yog ua los ntawm laser diffraction. Qhov loj me me ntawm HPMC txiav txim siab nws cov solubility thiab homogeneity ntawm cov khoom kawg. Kev ntsuas viscosity yog lwm qhov tseem ceeb tsis zoo rau HPMC thiab feem ntau yog ua los ntawm viscometer. Kev ntsuas viscosity xyuas kom meej tias HPMC muaj cov tuab uas xav tau los ua haujlwm zoo hauv nws daim ntawv thov.
Kev ntsuam xyuas cov dej noo kuj tseem ceeb heev rau kev tswj hwm HPMC kom zoo. Cov dej noo cuam tshuam rau kev ruaj ntseg, solubility, thiab viscosity ntawm HPMC thiab tuaj yeem ua rau cov tshuaj degradation. Cov dej noo ntawm HPMC tau txiav txim siab los ntawm Karl Fischer titration.
Nyob rau hauv cov ntsiab lus, hydroxypropyl methylcellulose yog ib qho tseem ceeb excipient nyob rau hauv cov kws tshuaj thiab zaub mov industries vim nws film-forming, thickening thiab binding zog. Qhov zoo ntawm HPMC yog ib qho tseem ceeb los xyuas kom meej qhov kev nyab xeeb thiab kev ua tau zoo ntawm cov khoom, thiab kev tswj xyuas zoo xws li kev ntsuas particle loj, ntsuas viscosity, thiab ntsuas dej noo yuav tsum tau ua. Nrog rau kev tswj xyuas kom zoo, HPMC yog cov khoom muaj kev nyab xeeb thiab siv tau zoo hauv ntau daim ntawv thov.
Post lub sij hawm: Aug-09-2023