Nrog rau kev txhim kho txuas ntxiv ntawm kev lag luam kws tshuaj thiab kev nce qib ntawm cov cuab yeej siv tshuaj, qhov kev thov rau cov ntaub ntawv tshuaj noj kuj nce ntxiv. Ntawm ntau hom tshuaj, tshuaj ntsiav tau dhau los ua daim ntawv siv dav hauv kev lag luam kws tshuaj vim lawv cov bioavailability zoo thiab kev ua raws li tus neeg mob. Nyob rau hauv xyoo tas los no, HPMC (hypromellose) khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob, hypromellose, HPMC (hypromellose) mus rau qhov chaw tseem ceeb hauv kev tsim tshuaj.
(1) Lub ntsiab lus tseem ceeb ntawm HPMC khoob khoob khoob
HPMC, los yog hypromellose, yog ib txwm muab tau los ntawm polymer compound feem ntau tau los ntawm cov ntaub ntoo los yog paj rwb fiber ntau los ntawm kev kho tshuaj. Cov qauv tshwj xeeb ntawm HPMC muab nws lub cev zoo thiab cov khoom siv tshuaj lom neeg, xws li siab pob tshab, zoo txhua yam muaj zog, ruaj khov solubility, thiab haum viscosity. Cov khoom no ua rau HPMC dav siv nyob rau hauv ntau lub teb, tshwj xeeb tshaj yog nyob rau hauv kws tshuaj.
(2) Lub ntsiab zoo ntawm HPMC npliag capsules
1. Nroj tsuag keeb kwm thiab neeg tsis noj nqaij compatibility
Cov khoom siv raw ntawm HPMC npliag capsules feem ntau yog los ntawm cov nroj tsuag fiber ntau, uas ua rau nws yog qhov kev xaiv zoo tshaj plaws rau cov neeg tsis noj nqaij. Tsis zoo li ib txwm gelatin tsiav tshuaj, HPMC khoob tsiav tshuaj tsis muaj tsiaj cov khoom xyaw, yog li lawv cov lag luam xav tau loj hlob sai sai hauv cov zaub noj tsis huv, kev cai dab qhuas lossis kev ntseeg. Qhov kom zoo dua no tsis tsuas yog ua raws li cov neeg siv khoom niaj hnub no kev txhawj xeeb txog kev noj qab haus huv thiab kev tiv thaiv ib puag ncig, tab sis kuj tseem muaj kev txhawb zog rau cov tuam txhab tshuaj kom nthuav dav thoob ntiaj teb kev lag luam.
2. Kev ruaj ntseg tshuaj zoo
HPMC khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob. Cov cuab yeej no ua rau nws muaj txiaj ntsig zoo thaum khaws cia thiab kev thauj mus los. Nyob rau hauv sib piv, gelatin capsules yog nquag mus rau cross-linking tshua nyob rau hauv high kub thiab high humidity ib puag ncig, uas cuam tshuam rau solubility thiab bioavailability ntawm cov tshuaj. HPMC tsis muaj tshuaj ntsiav tuaj yeem khaws cov khoom xyaw nquag ntawm cov tshuaj zoo dua thiab txuas ntxiv lub txee lub neej ntawm cov tshuaj.
3. Solubility zoo heev thiab bioavailability
HPMC npliag capsules muaj qhov nrawm nrawm nrawm thiab nqus tau siab hauv tib neeg lub cev, uas tso cai rau cov tshuaj tso tawm sai sai hauv lub cev thiab ua tiav cov txiaj ntsig zoo tshaj plaws. Nws solubility tsis tshua cuam tshuam los ntawm pH tus nqi ntawm ib puag ncig thiab tuaj yeem tswj tau qhov kev sib cais ruaj khov nyob rau hauv ntau qhov pH. Tsis tas li ntawd, HPMC khoob tsiav tshuaj muaj cov nplaum muaj zog nyob rau hauv lub plab zom mov, uas ua kom yooj yim ntawm kev nqus cov tshuaj thiab ntxiv txhim kho cov tshuaj tsis muaj tshuaj.
4. Kho kom haum rau ntau yam kev siv hauv ntau hom tshuaj
HPMC khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob. Tsis tas li ntawd, HPMC khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob, muaj lub zog siab thiab zoo sealing, uas tuaj yeem tiv thaiv cov tshuaj kom tsis txhob damp lossis oxidized. Vim yog qhov nruab nrab ntawm HPMC khoob tsiav tshuaj, lawv tau sib haum nrog ntau yam khoom siv tshuaj, xws li npaj cov khoom, ua kua npaj, thiab lwm yam.
5. Txo qhov kev pheej hmoo ntawm kev tsis haum tshuaj
Lwm qhov txiaj ntsig tseem ceeb ntawm HPMC npliag capsules yog lawv cov hypoallergenicity. Piv nrog rau cov tshuaj ntsiav tshuaj gelatin, HPMC capsules tsis muaj cov khoom xyaw protein, yog li qhov kev pheej hmoo ntawm kev tsis haum tshuaj txo qis heev. Qhov no yog qhov tseem ceeb tshwj xeeb rau cov neeg mob uas muaj kev fab tshuaj rau cov tsiaj protein, ua kom cov tshuaj muaj kev nyab xeeb dua rau cov neeg mob no.
(3) Cov kev sib tw thiab kev cia siab ntawm HPMC npliag capsules hauv kev tsim tshuaj
Txawm hais tias HPMC khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob. Piv txwv li, tus nqi siab dua ntawm HPMC khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khawm Tsis tas li ntawd, cov dej noo ntawm HPMC khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob.
Nrog rau kev nce qib ntawm cov thev naus laus zis thiab kev nthuav dav ntawm cov nplai ntau lawm, cov nqi tsim khoom ntawm HPMC cov tshuaj ntsiav khoob yuav tsum tau txo qis ntxiv. Nyob rau tib lub sijhawm, cov neeg siv khoom xav tau nce ntxiv rau kev noj qab haus huv thiab kev tiv thaiv ib puag ncig yuav txhawb nqa daim ntawv thov ntawm HPMC khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob. Ib qho ntxiv, cov tshuaj kho kom zoo ntawm HPMC khoob tsiav tshuaj thiab kev txhim kho cov ntaub ntawv tshiab yuav txuas ntxiv txhim kho hauv kev lag luam kws tshuaj.
HPMC khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob, tau qhia cov kev cia siab dav dav hauv kev tsim tshuaj, vim tias lawv cov hauv paus chiv keeb, tshuaj lom neeg ruaj khov, zoo solubility thiab bioavailability, kev siv dav dav thiab kev ua xua. Txawm tias ntsib qee qhov kev cov nyom, nrog kev nce qib ntawm kev lag luam thev naus laus zis, muab cov tuam txhab kev lag luam hauv tsev, muab cov tuam txhab kev lag luam nrog cov kev xaiv thiab cov kev xaiv ntau ntxiv.
Post lub sij hawm: Sep-03-2024