Qhia
Hydroxypropyl methylcellulose, feem ntau hu ua HPMC, yog cov dej-soluble polymer dav siv hauv tshuaj, tshuaj pleev ib ce, zaub mov thiab lwm yam lag luam. HPMC tuaj yeem siv ua thickener, binder, emulsifier thiab stabilizer.
1. Xaiv HPMC qib uas tsim nyog
Lub solubility ntawm HPMC nyob ntawm nws qhov hnyav molecular, qib ntawm kev hloov, thiab particle loj. Xaiv cov qib raug ntawm HPMC yog ib qho tseem ceeb los xyuas kom meej nws cov solubility zoo nyob rau hauv ib daim ntawv thov.
Piv txwv li, tsis tshua muaj molecular hnyav HPMC muaj zoo solubility nyob rau hauv dej thiab organic solvents tshaj li siab molecular hnyav HPMC. Txawm li cas los xij, siab molecular hnyav HPMC muaj cov khoom ua yeeb yaj kiab zoo dua, uas ua rau nws haum rau cov ntsiav tshuaj txheej.
Ib yam li ntawd, HPMC nrog qib siab ntawm kev hloov pauv yog soluble hauv dej ntau dua li HPMC nrog rau qib qis ntawm kev hloov pauv. HPMC nrog rau qib qis ntawm kev hloov pauv feem ntau yog siv nyob rau hauv kev tsim tawm-tso tawm vim nws tsim cov matrix ruaj khov thiab ntom.
Qhov loj me me ntawm HPMC kuj cuam tshuam rau nws cov solubility. HPMC nplua particles yaj sai dua li coarse hais. Yog li ntawd, nws yog ib qho tseem ceeb los xaiv qhov tseeb HPMC particle loj rau ib daim ntawv thov tshwj xeeb.
2. Siv cov kuab tshuaj kom raug
Lub solubility ntawm HPMC nyob ntawm qhov xwm txheej ntawm cov kuab tshuaj. HPMC yog soluble hauv dej thiab qee cov kuab tshuaj organic, xws li ethanol, methanol, thiab isopropyl cawv. Txawm li cas los xij, kev solubility ntawm HPMC hauv cov kuab tshuaj organic nyob ntawm nws qhov polarity.
Dej yog cov kuab tshuaj ntau tshaj plaws rau HPMC vim tias nws tsis muaj tshuaj lom, pheej yig, thiab yooj yim siv. Kev solubility ntawm HPMC hauv dej tuaj yeem txhim kho los ntawm kev ntxiv ntsev los yog kho cov pH.
Kev lag luam kws tshuaj feem ntau siv cov kuab tshuaj organic xws li ethanol, methanol, thiab isopropyl cawv kom yaj HPMC hauv cov tshuaj xws li ntsiav tshuaj, tshuaj ntsiav, thiab tshuaj hauv qhov ncauj. Txawm li cas los xij, tej zaum yuav muaj qee qhov tsis zoo rau kev siv cov kuab tshuaj organic, xws li toxicity, flammability, thiab ib puag ncig kev txhawj xeeb.
3. Cov txheej txheem dispersion tsim nyog
Cov txheej txheem ntawm dispersing HPMC nyob rau hauv cov kuab tshuaj kuj muaj feem xyuam rau nws solubility. Cov txheej txheem feem ntau ntawm kev tawg HPMC yog ntub dej granulation, nyob rau hauv uas HPMC yog tov nrog lwm yam excipients thiab hnyav yog ntxiv los ua ib tug muab tshuaj txhuam. Tom qab ntawd lub paste yog qhuav thiab sieved kom tau granules.
Txawm li cas los xij, cov txheej txheem ntub dej granulation tsis tsim nyog yuav ua rau tsis zoo solubility thiab solubility ntawm HPMC hauv cov khoom kawg. Yog li ntawd, nws yog ib qho tseem ceeb uas yuav tsum tau siv cov txheej txheem ntub dej kom tsim nyog (piv txwv li, kev sib xyaw kom zoo, ziab, thiab sieving) kom tau txais cov granules ntawm qhov loj thiab ntom.
Lwm txoj kev ntawm HPMC dispersion yog cov txheej txheem qhuav granulation, uas HPMC yog tov nrog lwm yam excipients thiab compressed rau hauv ntsiav tshuaj. Tom qab ntawd cov ntsiav tshuaj yog av thiab sieved kom tau granules. Thaum siv cov tshuaj rhiab heev, cov granulation qhuav yog nyiam thiab cov kuab tshuaj yuav tsum tsis txhob siv.
4. Cia tej yam kev mob
Cia tej yam kev mob ntawm HPMC kuj cuam tshuam nws solubility. HPMC yuav tsum tau muab cia rau hauv qhov chaw qhuav, txias thiab tsaus kom tsis txhob ya raws thiab tshav ntuj. Cov dej noo ua rau HPMC o, yog li cuam tshuam rau nws cov solubility.
Hauv kev xaus
Xaiv cov qib HPMC uas tsim nyog, siv cov kuab tshuaj tsim nyog, tsim nyog dispersion thev naus laus zis, thiab kev cia khoom tsim nyog yog qhov tseem ceeb uas cuam tshuam rau kev solubility ntawm HPMC. Los ntawm kev xav txog cov xwm txheej no, kev solubility ntawm HPMC tuaj yeem ua kom zoo kom ua tiav qhov kev xav tau ntawm cov khoom kawg.
Post lub sij hawm: Sep-13-2023