ʻO ka Hydroxypropyl methylcellulose (HPMC) kahi mea hoʻohana nui i hoʻohana nui ʻia i ka lāʻau lapaʻau, meaʻai a me nā ʻoihana hoʻonaninani. Lawe ʻia kēia derivative cellulose mai ka cellulose kūlohelohe a hoʻololi ʻia e hoʻokō i nā waiwai kikoʻī, e lilo ia i mea waiwai nui i nā ʻano hana like ʻole.
1. Hoʻomaka i ka Hydroxypropyl Methylcellulose (HPMC)
1.1. ʻO ke kinona a me nā waiwai
ʻO ka Hydroxypropylmethylcellulose kahi polymer semi-synthetic i loaʻa mai ka cellulose, ka mea nui i kūkulu ʻia o nā pā hale kanu. ʻO ka hoʻolālā kemika o HPMC he mau ʻāpana iwi kuamoʻo cellulose i hoʻopili ʻia i nā hui hydroxypropyl a me methyl. ʻO ke kiʻekiʻe o ka hoʻololi ʻana o kēia mau pūʻulu pili i ka solubility, viscosity, a me nā waiwai kino ʻē aʻe o ka polymer.
ʻO ka HPMC maʻamau he keʻokeʻo a keʻokeʻo paha ke nānā aku, ʻaʻohe ʻala a ʻono ʻole. Hiki ke hoʻoheheʻe ʻia i loko o ka wai a hoʻohua i nā ʻoluʻolu a me ka viscous, e waiwai ai ia i nā ʻano hana like ʻole.
1.2. Kaʻina hana hana
ʻO ka hana ʻana o ka hydroxypropyl methylcellulose e pili ana i ka etherification o cellulose me ka propylene oxide a me ka methyl chloride. Hoʻololi kēia kaʻina i nā pūʻulu hydroxyl i nā kaulahao cellulose, e alakaʻi ana i ka hoʻokumu ʻana o nā hui hydroxypropyl a me methyl ether. ʻO ka hoʻomalu ʻana i ke kiʻekiʻe o ka hoʻololi ʻana i ka wā o ke kaʻina hana e hiki ai ke hana maʻamau o nā waiwai HPMC.
2. Ka waiwai kino a me ke kemika
2.1. Solubility a me ka viscosity
ʻO kekahi o nā waiwai koʻikoʻi o ka HPMC ʻo kona hiki ke hoʻoheheʻe ʻia i ka wai. ʻO ke kiʻekiʻe o ka hoʻoheheʻe ʻana ma muli o ke degere o ka hoʻololi ʻana a me ke kaumaha molekala. He kūpono kēia ʻano solubility no nā ʻano hana like ʻole e koi ana i ka hoʻokuʻu ʻia ʻana a i ʻole ka hana gel.
Hiki ke ho'ololi 'ia ka viscosity o ka HPMC solutions, mai ka ha'aha'a a hiki i ke ki'eki'e viscosity grades. He mea koʻikoʻi kēia waiwai no ka hoʻopili ʻana i nā waiwai rheological o nā mea hoʻohālikelike e like me ka creams, gels a me nā hoʻonā ophthalmic.
2.2. Hana kiʻiʻoniʻoni
ʻIke ʻia ʻo HPMC no kāna mau hana hana kiʻiʻoniʻoni, hana ia i mea hoʻohui kūpono no ka uhi ʻana i nā papa a me nā granules. ʻO ka kiʻiʻoniʻoni i loaʻa mai he mea akaka a maʻalahi, e hāʻawi ana i kahi papa pale no ka lāʻau lapaʻau ikaika (API) a me ka paipai ʻana i ka hoʻokuʻu ʻia.
2.3. Paʻa wela
ʻO ka Hydroxypropyl methylcellulose ka paʻa wela maikaʻi, e ʻae iā ia e kū i kahi ākea o nā wela i ʻike ʻia i ka wā o ka hana ʻana. Mālama kēia waiwai i ka hana ʻana i nā ʻano dosage paʻa, me nā papa a me nā capsules.
3. Hoʻohana i ka hydroxypropyl methylcellulose
3.1. ʻoihana lāʻau lapaʻau
Hoʻohana nui ʻia ʻo HPMC i ka lāʻau lapaʻau ma ke ʻano he excipient i nā papa papa a loaʻa nā ʻano hoʻohana like ʻole. Hoʻohana ia ma ke ʻano he mea hoʻopaʻa, hoʻomalu i ka wehe ʻana a me ka hoʻokuʻu ʻana i nā mea hana. Eia kekahi, ʻo kāna mau mea hana kiʻiʻoniʻoni e kūpono ia no ka uhi ʻana i nā papa e hāʻawi i kahi pale pale.
I loko o ka wai hoʻoheheʻe waha, hiki ke hoʻohana ʻia ka HPMC ma ke ʻano he mea hoʻomaha, mānoanoa, a i ʻole e hoʻoponopono i ka viscosity. He mea kaulana kona hoʻohana ʻana i nā hoʻonā ophthalmic no kāna mau waiwai mucoadhesive, e hoʻomaikaʻi ai i ka bioavailability ocular.
3.2. ʻOihana meaʻai
Hoʻohana ka ʻoihana meaʻai i ka HPMC ma ke ʻano he mānoanoa a me ka gelling agent i nā ʻano huahana like ʻole. ʻO kona hiki ke hana i nā gels maʻemaʻe a me ka mālama ʻana i ka viscosity he mea waiwai ia i nā noi e like me nā kīʻaha, nā lole a me nā confectionery. ʻOi pinepine ʻia ka HPMC ma mua o nā mānoanoa kuʻuna ma muli o kāna versatility a me ka nele o ka hopena i nā waiwai sensory o nā huahana meaʻai.
3.3. Nā mea hoʻonani a me nā huahana mālama pilikino
I loko o nā mea hoʻonaninani, hoʻohana ʻia ʻo HPMC no kona mānoanoa, hoʻopaʻa a me nā waiwai hana kiʻiʻoniʻoni. Loaʻa maʻamau ia i loko o nā ʻaila, lotion, a me nā huahana mālama lauoho. ʻO ka hiki i ka polymer ke hoʻomaikaʻi i ke ʻano a me ke kūpaʻa o nā formulations e kōkua i kāna hoʻohana ākea i ka ʻoihana hoʻonaninani.
3.4. ʻOihana kūkulu hale
Hoʻohana ʻia ʻo HPMC i ka ʻoihana hana ma ke ʻano he mea mālama wai no nā mortar sima a me nā mea gypsum. ʻO kāna hana e hoʻonui i ka processability, pale i nā māwae, a hoʻomaikaʻi i ka adhesion.
4. Nā manaʻo hoʻoponopono a me ka ʻike palekana
4.1. Kūlana hoʻoponopono
ʻIke ʻia ka Hydroxypropyl methylcellulose he palekana (GRAS) e nā hui hoʻoponopono e like me ka US Food and Drug Administration (FDA) a me ka European Food Safety Authority (EFSA). Hoʻokō ia i nā kūlana pharmacopoeial like ʻole a ua helu ʻia i loko o kā lākou mau monographs.
4.2. ʻIke palekana
Ma ke ʻano he mea hoʻohana nui ʻia, loaʻa iā HPMC kahi ʻike palekana maikaʻi. Eia naʻe, pono e makaʻala ka poʻe me ka maʻi allergies i ʻike ʻia i ka cellulose derivatives. Hoʻoponopono paʻa ʻia ka neʻe ʻana o ka HPMC i ke ʻano e hōʻoia i ka palekana, he mea koʻikoʻi ia no nā kānaka. Hoʻopili nā mea hana i nā alakaʻi i hoʻokumu ʻia.
5. Ka hopena a me nā mea e hiki mai ana
Ua puka mai ka Hydroxypropyl methylcellulose ma ke ʻano he mea hoʻohana nui me nā noi he nui i ka lāʻau lapaʻau, meaʻai, nā mea hoʻonaninani a me nā ʻoihana kūkulu. ʻO kāna hui kūʻokoʻa o ka solubility, ka mana viscosity a me nā waiwai hana kiʻiʻoniʻoni e lilo ia i mea waiwai nui i nā ʻano hana he nui.
ʻO ka hoʻomau ʻana i ka noiʻi a me ka hoʻomohala ʻana i ka ʻepekema polymer hiki ke alakaʻi i nā holomua hou i ka hana HPMC e hoʻokō i nā pono o ka ʻoihana. Ke hoʻomau nei ka noi no ka hoʻopuka hoʻokuʻu ʻana a me ka hoʻomohala ʻana i nā huahana hou, hiki ke mālama ʻia ka hydroxypropyl methylcellulose i kāna kūlana koʻikoʻi ma ke ʻano he mea hoʻohana.
Ka manawa hoʻouna: Jan-15-2024