ʻO Hydroxypropyl Methylcellulose (HPMC) he polymer koʻikoʻi wai-soluble i hoʻohana nui ʻia i nā lāʻau lapaʻau, nā meaʻai, nā uhi, nā mea kūkulu hale a me nā māla ʻē aʻe. ʻO ka viscosity solution o HPMC kahi kumu nui e pili ana i kāna hana a me ka hoʻohana ʻana, a he hopena koʻikoʻi ka mahana i ka viscosity o ka wai wai HPMC.
1. Nā hiʻohiʻona viscosity o ka hopena HPMC
ʻO ka HPMC kahi mea polymer me nā waiwai hoʻoheheʻe thermally reversible. Ke hoʻoheheʻe ʻia ka HPMC i ka wai, hōʻike ʻia ka wai wai i hana ʻia i nā hiʻohiʻona wai non-Newtonian, ʻo ia hoʻi, hoʻololi ka viscosity solution me nā loli o ka shear rate. Ma ka mahana maʻamau, hana maʻamau nā hāʻina HPMC e like me ka wai pseudoplastic, ʻo ia hoʻi, ʻoi aku ka nui o ka viscosity ma nā ʻāpana ʻoki haʻahaʻa, a e emi ana ka viscosity i ka piʻi ʻana o ka nui o ka shear.
2. Ka hopena o ka mahana ma ka viscosity o ka HPMC solution
Loaʻa i nā hoʻololi wela ʻelua mau ʻano hopena koʻikoʻi i ka viscosity o nā ʻoluʻolu wai HPMC: hoʻonui i ka neʻe wela o nā kaulahao molekala a me nā loli i ka launa pū ʻana.
(1) Piʻi ka neʻe wela o nā kaulahao mole
Ke piʻi ka mahana, piʻi ka neʻe wela o ka HPMC molecular chain, ka mea e hoʻonāwaliwali ai nā paʻa hydrogen a me nā ikaika van der Waals ma waena o nā molekala a me ka hoʻonui ʻana o ka wai o ka hopena. Ke emi nei ka viscosity o ka hoʻonā ma muli o ka emi ʻana o ka entanglement a me ka hoʻopili kino ʻana ma waena o nā kaulahao mole. No laila, hōʻike nā haʻina wai HPMC i ka viscosity haʻahaʻa ma nā wela kiʻekiʻe.
(2) Hoʻololi i ka pilina pili
Hiki i nā hoʻololi wela ke hoʻopili i ka solubility o nā molekala HPMC i ka wai. He polymer ka HPMC me nā waiwai thermogelling, a hoʻololi nui kona solubility i ka wai me ka mahana. Ma nā ha'aha'a ha'aha'a, ho'okumu nā pū'ulu hydrophilic ma ke kaulahao mole HPMC i nā pa'a hydrogen pa'a me nā molekole wai, a pēlā e mālama ai i ka solubility maika'i a me ka viscosity ki'eki'e. Eia nō naʻe, i ka wā e piʻi ai ka mahana i kahi pae, hoʻonui ʻia ka pilina hydrophobic ma waena o nā kaulahao molekala HPMC, e alakaʻi ana i ka hoʻokumu ʻana o kahi ʻano pūnaewele ʻekolu-dimensional a i ʻole gelation i loko o ka hopena, e hoʻonui koke i ka viscosity solution ma lalo o kekahi mau kūlana. Kapa ʻia kēia ʻano he "thermal gel" phenomenon.
3. ʻIke hoʻokolohua o ka mahana ma ka HPMC solution viscosity
Ua hōʻike ʻia nā haʻawina hoʻokolohua ma loko o kahi pae wela maʻamau (e laʻa, 20°C a 40°C), e emi mālie ana ka viscosity o nā haʻina wai wai HPMC me ka piʻi ʻana o ka mahana. ʻO kēia ke kumu e hoʻonui ai ka wela kiʻekiʻe i ka ikehu kinetic o nā kaulahao molekala a hoʻemi i nā pilina intermolecular, a laila e hōʻemi ana i ka friction kūloko o ka hopena. Eia naʻe, ke piʻi mau ka mahana a hiki i ke kiko gel wela o HPMC (maʻamau ma waena o 60°C a me 90°C, ma muli o ke degere o ka hoʻololi ʻana a me ke kaumaha molekala o HPMC), piʻi koke ka viscosity solution. ʻO ka loaʻa ʻana o kēia mea pili i ka hoʻopili ʻana a me ka hoʻohui ʻana o nā kaulahao molekala HPMC.
4. Ka pilina ma waena o ka mahana a me ka HPMC structural parameters
ʻAʻole pili wale ka viscosity solution o HPMC i ka mahana, akā pili pū kekahi i kona ʻano mole. No ka laʻana, ʻo ke degere o ka hoʻololi ʻana (ʻo ia hoʻi, ka maʻiʻo o ka hydroxypropyl a me ka methyl substituents) a me ke kaumaha molekala o HPMC he hopena koʻikoʻi i kāna ʻano gel thermal. ʻO ka HPMC me kahi kiʻekiʻe o ka hoʻololi ʻana e mālama i kahi viscosity haʻahaʻa i kahi ākea ākea ma muli o kāna mau pūʻulu hydrophilic, ʻoiai ʻo HPMC me kahi haʻahaʻa haʻahaʻa o ka hoʻololi ʻana e hana i nā gels thermal. Eia kekahi, ʻoi aku ka nui o nā hopena HPMC me ke kaumaha molekala kiʻekiʻe e hoʻonui i ka viscosity i nā wela kiʻekiʻe.
5. Noʻonoʻo no ka hoʻohana ʻana i ka ʻenehana a me ka hoʻomaʻamaʻa
Ma nā noi kūpono, pono e koho ʻia nā ʻano HPMC kūpono e like me nā kūlana wela kūikawā. No ka laʻana, ma nā wahi wela kiʻekiʻe, pono e koho ʻia ʻo HPMC me ke kūpaʻa wela kiʻekiʻe e pale i ka gelation thermal. Ma lalo o nā kūlana wela haʻahaʻa, pono e noʻonoʻo ʻia ka solubility a me ka viscosity stability o HPMC.
He mea koʻikoʻi ka hopena o ka mahana ma ka viscosity o ka HPMC aqueous solution. Ma ke kahua lāʻau lapaʻau, hoʻohana pinepine ʻia ka HPMC ma ke ʻano he mea hoʻokuʻu hoʻomau no ka hoʻomākaukau ʻana i ka lāʻau lapaʻau, a ʻo kona ʻano viscosity e pili pono i ka lāʻau hoʻokuʻu lāʻau. I ka ʻoihana meaʻai, hoʻohana ʻia ʻo HPMC e hoʻomaikaʻi i ke ʻano a me ke kūpaʻa o nā huahana, a pono e hoʻoponopono ʻia ka hilinaʻi o ka wela o kāna viscosity solution e like me ka mahana hana. I nā mea hana, hoʻohana ʻia ʻo HPMC ma ke ʻano he mānoanoa a me ka mea mālama wai, a ʻo kāna mau hiʻohiʻona viscosity e pili ana i ka hana hana a me ka ikaika waiwai.
ʻO ka hopena o ka mahana ma ka viscosity o ka HPMC aqueous solution he kaʻina hana paʻakikī e pili ana i ka neʻe wela o ke kaulahao mole, ka pilina o ka hopena, a me nā waiwai o ka polymer. 'O ka holo'oko'a, e emi ana ka viscosity o ka HPMC aqueous solutions me ka pi'i 'ana o ka mahana, akā, ma kekahi mau pae wela, hiki ke ho'oulu 'ia ka wai wela. ʻO ka hoʻomaopopo ʻana i kēia hiʻohiʻona he koʻikoʻi alakaʻi koʻikoʻi no ka hoʻohana pono ʻana a me ke kaʻina hana o ka HPMC.
Ka manawa hoʻouna: Jul-10-2024