ʻO ka Hydroxypropyl methylcellulose (HPMC) he ether cellulose koʻikoʻi, hoʻohana nui ʻia i ke kūkulu ʻana, ka lāʻau lapaʻau, ka meaʻai, nā kemika o kēlā me kēia lā a me nā māla ʻē aʻe. ʻO ka HPMC he polymer hiki ke hoʻoheheʻe ʻia i ka wai i loaʻa ma ka hoʻololi kemika o ka cellulose maoli, me nā waiwai kino a me nā mea kemika maikaʻi loa.
1. Na waiwai kino
ʻO ke ʻano a me ka morphology: He keʻokeʻo a he melemele iki paha ka HPMC, ʻaʻala ʻole, ʻono ʻole, a maikaʻi ka wai. Hiki iā ia ke hana i kahi kiʻi ʻoniʻoni a i ʻole gel ma o nā ʻano hana like ʻole, e hana maikaʻi ai i nā noi he nui.
Solubility: Hiki ke hoʻoheheʻe ʻia ka HPMC i ka wai anuanu, akā hiki ʻole ke hoʻoheheʻe ʻia i ka wai wela. Ke piʻi ka mahana i kahi pae (maʻamau 60-90 ℃), nalowale ka HPMC i ka solubility i ka wai a hana i kahi gel. Hāʻawi kēia waiwai iā ia e hāʻawi i kahi hopena mānoanoa ke hoʻomehana ʻia, a hoʻi hou i kahi ʻano hoʻonā wai aniani ma hope o ka hoʻoilo. Eia kekahi, hiki ke hoʻoheheʻe ʻia ka HPMC i nā mea hoʻoheheʻe kūlohelohe e like me ka ethanol.
Viscosity: ʻO ka viscosity o ka solution HPMC kekahi o kāna mau waiwai kino koʻikoʻi. Pili ka viscosity i kona kaumaha molekala a me ka hoʻonā ʻana. Ma ka ʻōlelo maʻamau, ʻoi aku ka nui o ke kaumaha molekala, ʻoi aku ka kiʻekiʻe o ka viscosity o ka hopena. Loaʻa i ka HPMC kahi ākea ākea o ka viscosity a hiki ke hoʻoponopono ʻia e like me nā koi noi kikoʻī, kahi e hoʻohana nui ʻia ai i ke kūkulu ʻana, lāʻau lapaʻau, lāʻau kemika a me nā ʻoihana ʻē aʻe.
Waiwai hana kiʻiʻoniʻoni: He waiwai maikaʻi loa ko HPMC. Hiki iā ia ke hana i kahi kiʻiʻoniʻoni a paʻakikī ma hope o ka hoʻoheheʻe ʻana i ka wai a i ʻole nā mea hoʻoheheʻe organik. ʻO ka kiʻiʻoniʻoni heʻaila maikaʻi a me ka momona kū'ē, no laila, hoʻohana pinepineʻia e like me ka mea uhi i ka meaʻai a me ka lāʻau lapaʻau. Eia kekahi, ʻo ka kiʻiʻoniʻoni HPMC maikaʻi nō hoʻi ka pale ʻana i ka makū a hiki ke pale pono i ka mea o loko mai ka makū.
Paʻa wela: He kūpaʻa wela maikaʻi ka HPMC. ʻOiai e nalowale ana ka solubility a hana i ka gel i ke kiʻekiʻe wela, he kūpaʻa wela maikaʻi loa ia i kahi kūlana maloʻo a hiki ke kū i nā mahana hana kiʻekiʻe me ka ʻole o ka decomposition. Hāʻawi kēia hiʻohiʻona iā ia i ka pono i ka hana wela kiʻekiʻe.
2. Nā waiwai kemika
Paʻa kemika: He kūpaʻa kemika maikaʻi ka HPMC ma ka wela o ka lumi a ʻoi aku ka paʻa i nā waikawa, alkali a me nā paʻakai. No laila, i loko o ka nui o nā hopena kemika a i ʻole nā ʻōnaehana formulation, hiki i ka HPMC ke noho ma ke ʻano he stabilizer a ʻaʻole maʻalahi ke hana kemika me nā mea ʻē aʻe.
Paʻa pH: Paʻa mau ka HPMC ma ka laulā o ka pH 2-12, hiki ke hoʻohana ʻia i nā wahi pH like ʻole. ʻAʻole e hele ka HPMC i ka hydrolysis a i ʻole ka hoʻohaʻahaʻa ʻana ma lalo o nā kūlana acidic a i ʻole alkaline, e hoʻohana nui ʻia i ka meaʻai, ka lāʻau lapaʻau, a me nā mea hoʻonaninani.
ʻO ka biocompatibility a me ka ʻawaʻawa ʻole: He biocompatibility maikaʻi ka HPMC a hiki ke hoʻohana pono ʻia i ka lāʻau lapaʻau, ka meaʻai a me nā māla ʻē aʻe i loaʻa nā koi kiʻekiʻe loa no ke olakino kanaka. ʻO ka HPMC he mea ʻawaʻawa a ʻaʻole hoʻonāukiuki, a ʻaʻole e wāwahi ʻia i loko o nā moleke liʻiliʻi e nā enzyme digestive i loko o ke kino, no laila hiki ke hoʻohana ʻia ma ke ʻano he mea hoʻokuʻu hoʻomalu no nā lāʻau lapaʻau a i ʻole ka mānoanoa no ka meaʻai.
Hoʻololi kemika: Loaʻa i ka HPMC ka nui o nā pūʻulu hydroxyl i loko o kona ʻano mole, hiki ke hoʻomaikaʻi ʻia a hāʻawi ʻia i nā waiwai hou ma o ka hoʻololi hou ʻana. No ka laʻana, ma ka hana ʻana me nā aldehydes a i ʻole nā ʻakika organik, hiki i ka HPMC ke hoʻomākaukau i nā huahana me ke kūpaʻa wela kiʻekiʻe a i ʻole ke kūpaʻa wai. Eia hou, hiki ke hui pū ʻia ka HPMC me nā polymers ʻē aʻe a i ʻole nā mea hoʻohui e hana i nā mea hoʻohui e hoʻokō i nā pono o nā noi kikoʻī.
ʻO ka hoʻoheheʻe wai: He hygroscopicity ikaika ka HPMC a hiki ke hoʻopaʻa i ka makū mai ka lewa. Hāʻawi kēia waiwai iā HPMC e mānoanoa a hoʻoponopono i ka haʻahaʻa o ka huahana ma kekahi mau noi. Eia nō naʻe, i kekahi mau hihia, hiki ke hoʻopili ʻia ka nui o ka hoʻoheheʻe ʻana i ka wai i ka paʻa o ka huahana, no laila pono e noʻonoʻo ʻia ka hopena o ka haʻahaʻa ambient i ka hana o HPMC i ka wā e hoʻohana ai.
3. Nā kahua noi a me nā pono
Ma muli o kāna mau waiwai kino a me nā mea kemika, loaʻa i ka HPMC ka nui o ka waiwai noi ma nā kahua he nui. No ka laʻana, ma ke kahua kūkulu, hoʻohana ʻia ʻo HPMC ma ke ʻano he mea mānoanoa a me ka mālama ʻana i ka wai no nā mea hana sima no ka hoʻomaikaʻi ʻana i ke kūkulu ʻana a me ka lōʻihi o nā mea hale; i loko o ka lāʻau lapaʻau, hoʻohana pinepine ʻia ʻo HPMC e like me ka mea hoʻopili papa, ka mea hoʻokuʻu i hoʻokuʻu ʻia, a me nā mea hoʻopili capsule; ma ke kahua meaʻai, hoʻohana ʻia ia e like me ka mānoanoa, emulsifier, a me ka stabilizer e hoʻomaikaʻi i ka ʻono a me ke ʻano o ka meaʻai.
ʻO ka Hydroxypropyl methylcellulose kahi hana hiki ʻole ke hoʻololi ʻia i nā ʻoihana he nui ma muli o kāna mau waiwai kino a me nā kemika. ʻO kāna hana koʻikoʻi i ka hoʻoheheʻe wai, nā waiwai hana kiʻiʻoniʻoni, paʻa kemika, a me nā mea ʻē aʻe e hana ai ʻo HPMC i mea waiwai nui i ka ʻoihana a me ke ola o kēlā me kēia lā.
Ka manawa hoʻouna: ʻAukake-22-2024