Pharmacokinetics o Hydroxypropyl Methyl Cellulose

Hoʻohana mua ʻia ʻo Hydroxypropyl Methylcellulose (HPMC) ma ke ʻano he excipient i loko o nā hoʻomākaukau lāʻau lapaʻau ma mua o ke ʻano he lāʻau lapaʻau ikaika (API). No laila, ʻaʻole i aʻo nui ʻia nā waiwai pharmacokinetic a i kākau ʻia i hoʻohālikelike ʻia me nā lāʻau lapaʻau ikaika. Eia nō naʻe, he mea nui e hoʻomaopopo i ke ʻano o ka HPMC i loko o ke kino e hōʻoia i ka palekana a me ka hoʻohana pono ʻana i nā huahana lāʻau. Eia kahi ʻike pōkole:

Hoʻopili:

• ʻAʻole komo ʻia ka HPMC ma o ka ʻōpū o ka ʻōpū ma muli o kona kaumaha molecular kiʻekiʻe a me ke ʻano hydrophilic. Akā, noho ia i loko o ka gastrointestinal lumen a hoʻokuʻu ʻia i nā feces.

Kahele:

• No ka mea, ʻaʻole komo ʻo HPMC i ka ʻōnaehana ʻōnaehana, ʻaʻole ia e puʻunaue i nā ʻiʻo a i ʻole nā ​​​​mea i loko o ke kino.

Metabolism:

• ʻAʻole hoʻololi ʻia ka HPMC e ke kino. Loaʻa ka liʻiliʻi a ʻaʻohe biotransformation i loko o ka ʻōpū o ka ʻōpū.

Hoʻopau:

• ʻO ke ala mua o ka hoʻopau ʻana no ka HPMC ma o nā feces. Hoʻokuʻu ʻia ka HPMC ʻaʻole i hoʻololi ʻia i loko o nā feces. Hiki i kekahi mau ʻāpana liʻiliʻi o HPMC ke hoʻohaʻahaʻa ʻia e ka bacteria colonic ma mua o ka hemo ʻana.

Nā mea e pili ana i ka Pharmacokinetics:

• Hiki ke ho'ololi 'ia ka pharmacokinetics o ka HPMC e nā mea e like me ke kaumaha molekala, ke degere o ka ho'ololi 'ana, a me nā 'ano o ka ho'okumu 'ana (e like me ka papa matrix, ka uhi, ka ho'oku'u 'ana). Hiki i kēia mau mea ke hoʻopili i ka helu a me ka nui o ka hoʻoheheʻe ʻana o HPMC, a laila hiki ke hoʻopili i kona absorption a me ka hoʻopau ʻana.

Nā manaʻo palekana:

• Manaʻo ʻia ʻo HPMC he palekana no ka hoʻohana ʻana i nā ʻano lāʻau lapaʻau a he lōʻihi kona moʻolelo o ka hoʻohana ʻana i nā ʻano hoʻohana waha. Ua manaʻo ʻia he biocompatible a ʻaʻohe mea ʻawaʻawa, a ʻaʻole ia e kau i nā hopohopo palekana koʻikoʻi e pili ana i nā pharmacokinetics.

Pili pili kino:

• ʻOiai ʻaʻole pili pono nā waiwai pharmacokinetic o HPMC ponoʻī, ʻo ka hoʻomaopopo ʻana i kāna ʻano i loko o nā ʻano lāʻau lapaʻau he mea nui ia no ka hōʻoia ʻana i ka hana o nā huahana lāʻau, me ka hoʻokuʻu ʻana i ka lāʻau, bioavailability, a me ke kūpaʻa.

I ka hōʻuluʻulu ʻana, ʻaʻole komo ʻia ka Hydroxypropyl Methylcellulose (HPMC) i loko o ka ʻōnaehana ʻōnaehana a hoʻopau mua ʻia me ka loli ʻole i nā feces. Hoʻoholo mua ʻia kāna mau waiwai pharmacokinetic e kāna mau hiʻohiʻona physicochemical a me nā ʻano hoʻohālikelike. ʻOiai ʻaʻole hōʻike ʻo HPMC iā ia iho i nā ʻano pharmacokinetic maʻamau e like me nā lāʻau lapaʻau ikaika, ʻo kāna kuleana ma ke ʻano he excipient he mea koʻikoʻi ia no ka hoʻokumu ʻana a me ka hana o nā huahana lāʻau.