ʻO ka Hydroxypropyl methyl cellulose (HPMC) he mea maʻalahi a hoʻohana nui ʻia ka non-ionic cellulose ether, i hoʻohana pinepine ʻia i nā ʻoihana like ʻole ma muli o kāna mau ʻano waiwai. Hiki ke hoʻokaʻawale nui ʻia nā hōʻailona ʻenehana nui o HPMC i ke kino, kemika, a me nā waiwai hana, e hāʻawi ana kēlā me kēia i kona kūpono no nā noi kikoʻī.
1. Na Waiwai Kino
a. Ka nana aku
ʻO ka HPMC ka pauka keʻokeʻo a keʻokeʻo, ʻaʻohe ʻono a ʻono ʻole, e hōʻike ana i kona maʻemaʻe a kūpono hoʻi no ka hoʻohana ʻana i nā noi koʻikoʻi e like me nā lāʻau lapaʻau a me nā meaʻai.
b. Ka nui o ka ʻāpana
Hiki i ka nui o ka HPMC ke ho'opā i kona ho'ohehe'e a me ka ho'opuehu i ka wai a i 'ole nā mea ho'ohehe'e 'ē a'e. Loaʻa maʻamau ia i nā māka like ʻole, kahi e hoʻohele ʻia ai ka nui o ka ʻāpana mai ka pauka maikaʻi a hiki i ka pauka. ʻO ka nui o ka ʻāpana liʻiliʻi e alakaʻi pinepine i ka wikiwiki o ka hemo ʻana.
c. ʻAiʻi Nui
He hōʻailona koʻikoʻi ka ʻano nui, no ka mālama ʻana a me ka hana ʻana. Mai ka 0.25 a i ka 0.70 g/cm³, e pili ana i ka waiwai kahe o ka waiwai a me nā koi o ka pahu.
d. Māmā
Pono ka liʻiliʻi o ka makū ma HPMC e hōʻoia i ka paʻa a pale i ka clumping i ka wā e waiho ai. ʻO ka maʻamau maʻamau ka maʻamau ma lalo o 5%, pinepine ma kahi o 2-3%.
2. Na Waiwai Kemika
a. ʻO ka Methoxy a me ka Hydroxypropyl Content
ʻO nā pae hoʻololi o nā pūʻulu methoxy (–OCH₃) a me hydroxypropyl (–OCH₂CH₂OH) he mau hōʻailona kemika koʻikoʻi, e hoʻololi ana i ka solubility, ka wela gelation, a me ka viscosity o HPMC. Aia ka maʻiʻo methoxy maʻamau mai 19-30%, a me ka maʻi hydroxypropyl mai 4-12%.
b. ʻO ka viscosity
ʻO Viscosity kekahi o nā waiwai koʻikoʻi, e wehewehe ana i ka hana a HPMC i nā noi. Ana ʻia ia i loko o nā hāʻina wai, me ka hoʻohana maʻamau i ka viscometer rotational. Hiki ke loaʻa ka viscosity mai kahi mau keneta (cP) a ʻoi aku ma mua o 100,000 cP. Hiki i kēia laulā ākea ke hana maʻamau i nā kaʻina hana ʻoihana like ʻole.
c. Waiwai pH
ʻO ka pH o kahi solution 2% HPMC e hāʻule maʻamau ma waena o 5.0 a me 8.0. He mea koʻikoʻi kēia neutrality no ka hoʻohālikelike ʻana i nā formulations, ʻoi loa i nā lāʻau lapaʻau a me nā huahana meaʻai.
d. Maʻemaʻe a me nā haumia
Pono ka maʻemaʻe kiʻekiʻe, ʻoi aku ka nui o ka meaʻai a me nā māka lāʻau. ʻO nā mea haumia e like me nā metala kaumaha (e laʻa, ke kēpau, arsenic) pono e liʻiliʻi. Pono pinepine nā kikoʻī i nā metala kaumaha ma lalo o 20 ppm.
3. Pono Hana
a. Ka hoʻoheheʻe
Hiki ke hoʻoheheʻe ʻia ka HPMC i loko o ka wai anuanu a me ka wai wela, e hoʻoheheʻe ʻia a ʻaʻaʻa iki paha. He mea maikaʻi kēia hoʻoheheʻe ʻelua no nā ʻano hana like ʻole, e ʻae ana i ka maʻalahi i nā kūlana hana.
b. ʻO ka wai wela
ʻO kahi waiwai kūʻokoʻa o HPMC ʻo kona hiki ke hana i nā gels ma ka hoʻomehana ʻana. ʻO ka mahana gelation e pili ana i ke kiʻekiʻe o ka hoʻololi a me ka noʻonoʻo. Mai 50°C a i 90°C ka wela o ka gelation ma'amau. Hoʻohana ʻia kēia waiwai i nā noi e like me ka controlled-release formulations i nā lāʻau lapaʻau.
c. Hiki ke hana kiʻiʻoniʻoni
Hiki i ka HPMC ke hana i nā kiʻiʻoniʻoni ikaika, maʻalahi, a me ka ʻike. Hoʻohana nui ʻia kēia waiwai i ka uhi ʻana, encapsulation o nā lāʻau lapaʻau, a me ka glazing meaʻai.
d. Ka Hana Ili
Hōʻike ʻo HPMC i nā waiwai o ka honua, e hāʻawi ana i ka emulsification a me nā hopena stabilization. He mea pono kēia i nā mea hoʻonaninani, nā lāʻau lapaʻau, a me nā ʻoihana meaʻai kahi e pono ai nā emulsion paʻa.
e. Paʻa wai
ʻO kekahi o nā hiʻohiʻona o ka HPMC ʻo kona hiki ke mālama i ka wai. He mea maikaʻi loa ia i ka mālama ʻana i ka makū, he mea koʻikoʻi i nā noi e like me nā morta, plasters, a me nā mea hoʻonaninani.
4. Nā noi kikoʻī a me kā lākou mau koi
a. lāʻau lapaʻau
I ka ʻoihana lāʻau lapaʻau, hoʻohana ʻia ʻo HPMC ma ke ʻano he mea hoʻopaʻa, kiʻiʻoniʻoni-mua, a me ka mea hoʻokuʻu hoʻokuʻu. ʻO nā hōʻailona ʻenehana e like me ka maʻemaʻe kiʻekiʻe, nā māka viscosity kikoʻī, a me nā pae hoʻololi pololei he mea koʻikoʻi e hōʻoia i ka pono a me ka palekana i nā ʻōnaehana lawe lāʻau.
b. Kūkulu
Ma ke kūkulu ʻana, ʻoi aku ka nui o nā huahana sima a me ka gypsum, hoʻohana ʻia ʻo HPMC e hoʻomaikaʻi i ka hana, ka paʻa ʻana o ka wai, a me ka pili. Ma ʻaneʻi, he mea koʻikoʻi ka viscosity, ka nui o nā ʻāpana, a me nā waiwai paʻa wai.
c. ʻOihana Meaʻai
Hoʻohana ʻia ʻo HPMC ma ke ʻano he mānoanoa, emulsifier, a stabilizer i nā huahana meaʻai like ʻole. No nā noi meaʻai, ʻo nā hōʻailona o ka hoihoi e pili ana i ka maʻemaʻe kiʻekiʻe, non-toxicity, a me nā kikoʻī viscosity kikoʻī e hōʻoia i ke ʻano kūlike a me ke kūpaʻa.
d. Mālama Pilikino a me nā mea hoʻonani
Ma nā huahana mālama pilikino, ua waiwai ʻia ka HPMC no kona mānoanoa, emulsifying, a me nā waiwai hana kiʻiʻoniʻoni. ʻO nā hōʻailona koʻikoʻi e pili ana i ka solubility, viscosity, a me ka maʻemaʻe, e hōʻoia ana i ka hoʻohālikelike ʻana me nā mea ʻē aʻe a me ka paʻa o ka huahana hope.
5. Ka Mana Mana a me na Hana Hoao
ʻO ka hoʻomalu maikaʻi ʻana o HPMC e pili ana i ka hoʻāʻo ikaika ʻana i kāna mau waiwai kino a me ke kemika. ʻO nā ʻano hoʻokolohua maʻamau i hoʻohana ʻia:
a. Ana Viscosity
Ke hoʻohana nei i nā viscometers rotational e hoʻoholo i ka viscosity o nā hopena HPMC.
b. Ka Hoʻololi Hoʻololi
Hoʻohana ʻia nā ʻano e like me NMR spectroscopy e hoʻoholo i ka ʻike methoxy a me ka hydroxypropyl.
c. Hoʻoholo ʻana i ka maʻemaʻe
Hoʻohana ʻia nā ʻano hana titration a i ʻole nalo ma ka maloʻo (LOD) ʻo Karl Fischer.
d. ʻIkepili Nui
ʻO ka hoʻokaʻawale ʻana i ka laser a me nā ʻano kānana e ʻike ai i ka puʻunaue ʻana i ka nui o nā ʻāpana.
e. ana pH
Hoʻohana ʻia kahi mika pH e ana i ka pH o nā hoʻonā HPMC e hōʻoia i ka hāʻule ʻana i loko o ka pae i kuhikuhi ʻia.
f. ʻO ka hoʻāʻo metala kaumaha
ʻO ka ʻike kikoʻī hoʻoheheʻe atomika (AAS) a i ʻole ka nānā ʻana i ka plasma inductively coupled (ICP) no ka ʻike ʻana i nā haumia metala.
ʻO ka Hydroxypropyl methyl cellulose (HPMC) kahi mea hoʻohui multifunctional me kahi ākea o nā noi, pono i ka ʻike kikoʻī o kāna mau hōʻailona ʻenehana. ʻO nā waiwai kino e like me ka hiʻohiʻona, ka nui o ka ʻāpana, ka nui o ka nui, a me ka ʻoluʻolu o ka wai e hōʻoia i ka lawelawe ʻana a me ka hana kūpono. ʻO nā waiwai kemika me ka methoxy a me ka hydroxypropyl content, viscosity, pH, a me ka maʻemaʻe e kuhikuhi i kona kūpono no nā noi kikoʻī. ʻO nā waiwai hana e like me ka solubility, thermal gelation, ka hiki ke hana kiʻiʻoniʻoni, ka hana ʻili, a me ka paʻa ʻana o ka wai e hōʻike hou i kona versatility. Ma ka hoʻokō ʻana i nā ana hoʻomalu maikaʻi, hiki ke hoʻohana pono ʻia ka HPMC ma nā ʻoihana like ʻole, e hoʻokō ana i nā kuleana hana like ʻole mai nā lāʻau lapaʻau a hiki i ke kūkulu ʻana.
Ka manawa hoʻouna: Mei-22-2024