Hoʻohana ʻo HPMC i ka uhi papa

uhi papa hoʻohana mau ʻia i ka hoʻomākaukau ʻana i ke ʻano paʻa, e like me kauhi papa hiki ke maheleia na mea i paudauhi papa, pelletuhi papa, ʻāpanauhi papa, papauhi papa, capsuleuhi papa; Wahi auhi papa māhele ʻia nā mea i ke kōuhi papa, hapalua kiʻiʻoniʻoniuhi papa, kiʻiʻoniʻoniuhi papa (ma muli o nā ʻano mea polymer like ʻole, me ka entericuhi papa), mea kūikawāuhi papa (e like me ka stearic acid, paraffin, polysaccharide); Wahi auhi papa ʻenehana, hiki ke hoʻokaʻawale ʻia i ka sprayuhi papa, luuuhi papa, kaomi maloouhi papa, uilauhi papa a me ka laminatinguhi papa. Ma waena o lākou, e kāpīpīuhi papa ʻo ia ka mea i hoʻohana nui ʻia. ʻO kāna kumu, ʻo ia ka pulupuluuhi papa wai i loko o nā kulu noe e uhi ana i ka ʻili o nā mea (pauka, ʻāpana, papa). A maloʻo koke e hana i kauhi papa papa: e like me kauhi papa Ua māhele ʻia ke kumu i hiki ke hoʻoheheʻe ʻia i ka waiuhi papa, hikiwawe ka opuuhi papa, hiki ole ke hooheheeiauhi papa, hookuu lohiuhi papa, mea komouhi papa.

ʻO ke kuleana ouhi papa ʻo ia hoʻi: (1) moistureproof, māmā, kaʻawale ea e hoʻonui i ka paʻa o ka lāʻau; (2) E uhi i ke ala ʻino, e hoʻemi i ka hoʻoulu ʻana; (3) E hoʻomaikaʻi i ka helehelena, maʻalahi e ʻike; (4) E hoʻomalu i ka lāʻau hoʻokuʻu kahua, e like me i loko o gastric wai maʻalahi e hoʻopau ʻia i hoʻokuʻu ʻia i loko o ka ʻōpū: (5) hoʻomalu i ka hoʻopuehu ʻana i ka lāʻau, hoʻokuʻu wikiwiki: (6) lanakila i ka incompatibility, etc.uhi papa Pono nā mea e pono ai: ʻaʻohe mea ʻawaʻawa, ʻaʻohe inertia kemika, kūpaʻa i ka wela, ka māmā, ka wai, ka ea, a ʻaʻole i pane me kauhi papa lāʻau lāʻau; (2) hiki ke hoʻoheheʻe ʻia i loko o ka dispersion medium kūpono nouhi papa: (3) hiki ke hana i kahi papa hoʻomau, paʻa, ʻoluʻolu, kūʻē kūʻē a loaʻa kahi kaʻawale wai maikaʻi, ka hoʻokaʻawale ʻana i ka wai, ka uhi ʻana, ka ea permeability;④Pono kona solubility e hoʻokō i nā koi o - paʻa, i kekahi manawa ʻaʻole pono e hoʻopili ʻia e PH, i kekahi manawa hiki ke hoʻoheheʻe wale ʻia i kahi kikoʻī PH. ʻAʻole ʻike nui ʻia kahi ʻano mea i ʻike ʻia ma luna o ka manawa like, makemake ke kumu e hoʻohana i hui ʻiauhi papa mea hou aku, i mea e ao ai kekahi i kekahi.

Papapalapalauhi papa ʻo ia ka mea i hoʻohana nui ʻia, hoʻohana pinepine ia i ka ipuhaouhi papa a kanu ʻia ka paipuuhi papa (kiʻekiʻe ka ponouhi papa mīkiniuhi papa), ʻoi aku ka maikaʻi o ka hope no ke kiʻiʻoniʻoniuhi papa. Moena wai waiuhi papa ʻoi aku ka maikaʻi no nā mea me ka liʻiliʻi liʻiliʻi e like me ka pellets a me ka pauka. Hoʻohālikelike ʻia me ke kōuhi papa, kiʻiʻoniʻoniuhi papa he nui na pomaikai 1) Hoʻopōkole i ka manawa a hoʻemi i ke kumukūʻai waiwai; (2) ʻaʻohe piʻi nui o ka paona: (3) ʻaʻohe pono o ka papa lalo: (4) ikaika, ʻoki a me ka haʻihaʻi kūʻē: (5) hiki ke paʻi ʻia, ʻaʻole hoʻi e pili i ka leka chip;(6) Hiki ke pale pono i ka huahana mai ka mana o ka malamalama, ka ea a me ka wai; (7) ʻAʻohe hopena maikaʻi ʻole i ka wā hemo 8) huahana nani 9) hāʻawi i kahi manawa e hoʻohana ai i ka wai ʻoleuhi papa; Hiki ke hoʻohālikelike ʻia nā kaʻina hana a me nā mea. I kēia manawa ke kūkulu ʻana i nā huahana houuhi papa hoʻomākaukau maʻamau apono kiʻiʻoniʻoniuhi papa, kiʻiʻoniʻoniuhi papa ʻO ka haku mele ʻana me ka mea hana kiʻiʻoniʻoni (uhi papa mea), solvent, plasticizer, colorant, hiki ke hoʻohui i ka pore-causing agent, insoluble filler, etc.uhi papa ʻO ke kuhikuhi ʻana ke kī i ka holomua ouhi papa. I kēia manawa, kiʻiʻoniʻoni waiuhi papa ʻO nā mea maʻamau i hoʻohana ʻia me ka hydroxypropyl methyl cellulose (HPMC) a me ka hydroxypropyl cellulose (HPC). ʻO ka Polyethylene glycol (PEG), polyethylene pyrrolidone (PVP), nā mea hoʻoheheʻe enteric-soluble e pili ana i ka resin acrylic-soluble, hydroxypropyl methyl cellulose phthalate (HPMCP). Cellulose acetate phthalate ester (CAP). ʻO Shellac, nā mea hiki ʻole ke hoʻopili ʻia me ka ethyl cellulose (EC), zein.

I nā makahiki, kiʻiʻoniʻoniuhi papa ua holomua kamahao. ʻO ke kūlana kuʻunauhi papa hoʻohana pūnaeweleHPMC(hydroxypropyl methylcellulose) ma ke ʻano he polymer nui, i hoʻohana nui ʻia i kēia lā. HPMC-hoʻokumuuhi papa Hāʻawi nā ʻōnaehana i ka hana kūpono, akā aia kahi wahi no ka hoʻomaikaʻi ʻana. HPMCuhi papa ʻAʻole pili pono ke kiʻiʻoniʻoni i ka papa, maʻamau ka lōʻihiuhi papa ka manawa, ka hopena o ka hana lohi. ʻO ka hoʻolauna ʻana ma hope oPVA ma muli uhi papa Ua hoʻomaikaʻi hou nā ʻōnaehana i ka hana, e hopena i ka maikaʻiuhi papa ka hana a me ka wikiwiki o ka hana ʻana, ʻo ia hoʻi ka liʻiliʻi o nā hemahema i nā papa.

Ke piʻi aʻe ka viscosity o HPMC, piʻi like ka ikaika o ka kiʻiʻoniʻoni i hana ʻia e HPMC, a hiki i ka ikaika kiʻiʻoniʻoni kiʻekiʻe ʻaʻole e piʻi hou me ka piʻi ʻana o ka viscosity o HPMC.

I kauhi papa, i mea e loaa ai ka pono loauhi papa, hoʻomaikaʻi pinepine i kauhi papa wai paʻa maʻiʻo, e alakaʻi i kauhi papa ʻOi aku ka kiʻekiʻe o ka wai viscosity, koho haʻahaʻa viscosity HPMC hiki ke hoʻoponopono pono i kēia pilikia, akā ke alakaʻi nei i ka ikaika kiʻiʻoniʻoni. No ke kaulike ʻana i kēia mau pilikia māhoe, ua lilo ka hui ʻana i nā polymers i mea hana maʻamau.

E like me kaHPMCE15 maʻiʻo mahuahua lohi, ka viscosity o ka hui 'ana oHPMCE5 aHPMCE piʻi mālie hoʻi ka E15.

I ke kōuhi papa, ua hele pū mākou mai ke akamai a i ka ʻepekema. ʻO nā huahana i hoʻopaʻa ʻia i ke kō he mea ʻoluʻolu loa ia no ka mea he ʻono, ʻālohilohi, ʻono ka hopena e uhi ana i nā ʻono ʻawaʻawa. Akā ʻo nā pilikia nui loa i ke kōuhi papa lie i ka productivity and reproducibility. ʻO ke kōuhi papa He kaʻina hana lima paʻakikī a hoʻopau i ka manawa a hiki ke ʻokoʻa i kēlā me kēia pūʻulu ma muli o ke kanaka e hana ana i ka hana.uhi papa.