HPMC no ka Lapaau

HPMCno ka laau lapaauua lilo i kekahi o ka nui loa omālama ola kino aʻO nā mea kōkua lāʻau lapaʻau ma ka home a me nā ʻāina ʻē, no ka mea, aia ka HPMC no ka lāʻau lapaʻau i nā pono i loaʻa ʻole i nā mea kōkua ʻē aʻe.

1. Ka hoʻoheheʻe wai

Hiki ke hoʻoheheʻe ʻia ka HPMC no ka lāʻau lapaʻau i ka wai anuanu ma lalo o 40 ℃ a i ʻole 70% ethanol. ʻAʻole hiki ke hoʻoheheʻe ʻia i ka wai wela ma luna o 60 ℃, akā hiki ke hoʻoheheʻe ʻia.

2. Inertia kemika

ʻO ka HPMC no ka lāʻau lapaʻau no ka non-ionic cellulose ether, ʻaʻohe ionic charge a me nā paʻakai metala a i ʻole ionic organic compounds, no laila, i ka hoʻomākaukau ʻana i ke kaʻina hana, ʻaʻole i pane aku nā excipients me ia.

3. Paʻa

Paʻa ia i ka waikawa a me ka base, a hiki ke mālama ʻia i ka laulā o PH 3 ~ 11 no ka manawa lōʻihi me ka ʻole o ka loli ʻana o ka viscosity. Hiki ke kūpa'a ka viscosity maika'i i ka waiho 'ana i ka wā lō'ihi. ʻOi aku ka maikaʻi o nā mea hoʻohana lāʻau lapaʻau e hoʻohana ana i ka HPMC no ka lāʻau lapaʻau, ʻoi aku ka maikaʻi o kona kūpaʻa maikaʻi ma mua o ka hoʻohana ʻana i nā excipients kuʻuna (e like me dextrin, starch, etc.).

4. Hiki ke hoʻololi i ka viscosity

Hiki ke hoʻohālikelike ʻia nā derivatives HPMC o nā viscosity like ʻole e like me nā ʻano like ʻole, hiki ke hoʻololi i kona viscosity e like me kekahi mau lula, a he pilina laina maikaʻi, no laila hiki ke koho ʻia e like me nā pono o ka ratio. 2. 5 metabolic inertia HPMC ʻaʻole i komo i loko o ke kino ʻaʻole metabolized, ʻaʻole hāʻawi i ka wela, no laila he mea hoʻomākaukau lāʻau palekana palekana. .

5. Palekana

HPMCno ka laau lapaauua manaʻo ʻia he mea ʻawaʻawa ʻole a hoʻonāukiuki ʻole.

ʻO ka Hydroxypropyl methyl cellulose (HPMC) kahicelluloseetera i hana ʻia e ka hopena o ka chloromethane a me ka propylene oxide me ka cellulose kumu. ʻO ka pulupulu keʻokeʻo a ʻaneʻane keʻokeʻo paha, ʻaʻohe ʻala. Ua hoʻohana ʻia i ka ʻoihana lāʻau lapaʻau ma mua o 40 mau makahiki, a ua ʻae ʻia ma USP19 edition a me Chinese Pharmacopoeia 1990 edition. Ua loaʻa i nā hopena maikaʻi i nā mea hoʻopili kiʻiʻoniʻoni a me nā noi adhesive.

Papa lāʻau lapaʻauHPMCLoaʻa i ka hydroxypropyl methyl cellulose nā koi kiʻekiʻe e pili ana i nā mea maka, ʻenehana hana a me ka maikaʻi o ka huahana. I kēia mau makahiki i hala iho nei, ma lalo o ka mana o nā kulekele palekana e pili ana i ke kaiapuni, ua haʻalele kekahi mau ʻoihana liʻiliʻi liʻiliʻi liʻiliʻi ma East China mai ka mākeke, a me ka papa lāʻau lapaʻau.HPMChydroxypropyl methyl celluloseno ka laau lapaauUa hoʻopilikia pū ʻia ka ʻoihana, ua hoʻihoʻi ʻia kekahi mau mea hana liʻiliʻi, a ua hoʻomaikaʻi ʻia ka manaʻo.