ʻO Hydroxyethyl Cellulose (HEC) a me nā cellulose ethers (e like me hydroxypropyl methylcellulose (HPMC), methylcellulose (MC), hydroxypropyl cellulose (HPC) a me carboxymethyl cellulose (CMC)) he mau polymers multifunctional i hoʻohana nui ʻia i ka ʻoihana, kūkulu, lāʻau lapaʻau, meaʻai a me kēlā me kēia lā. ʻoihana kemika. Hana ʻia kēia mau cellulose derivatives ma ke kemika hoʻololi ʻana i ka cellulose a loaʻa ka wai hoʻoheheʻe maikaʻi, mānoanoa, kūpaʻa a me nā waiwai hana kiʻiʻoniʻoni.
1. Hydroxyethyl Cellulose (HEC)
1.1 Ke Kinohi a me nā waiwai
Hana ʻia ka Hydroxyethyl Cellulose (HEC) e ka hydroxyethylation o cellulose me ka ethylene oxide ma lalo o nā kūlana alkaline. ʻO ke ʻano kumu o HEC he paʻa eter i hoʻokumu ʻia e ka hoʻololi ʻana o ka pūʻulu hydroxyl i loko o ka mole cellulose e kahi hui hydroxyethyl. Hāʻawi kēia ʻano i nā waiwai kūʻokoʻa HEC:
Hiki ke hoʻoheheʻe ʻia i ka wai: Hiki ke hoʻoheheʻe ʻia ka HEC i ka wai anuanu a me ka wai wela e hana i kahi hopena colloidal akaka.
Mānoanoa: He mau waiwai mānoanoa ka HEC a hoʻohana nui ʻia i nā noi e koi ana i ka mana viscosity.
Paʻa: He kūpaʻa kiʻekiʻe ka hopena HEC ma nā pae pH like ʻole.
Biocompatibility: He mea ʻawaʻawa ʻole ʻo HEC, ʻaʻole hoʻonāukiuki, a aloha i ke kino kanaka a me ke kaiapuni.
1.2 Nā kahua noi
Nā mea kūkulu hale: hoʻohana ʻia ma ke ʻano he mānoanoa a me ka mea mālama wai no ka mortar sima a me nā huahana gypsum.
Nā uhi a me nā pena: hoʻohana ʻia e like me ka mānoanoa, ka mea hoʻomaha a me ka stabilizer.
Nā kemika o kēlā me kēia lā: hoʻohana ʻia e like me ka mānoanoa i nā mea e pono ai i kēlā me kēia lā e like me nā mea holoi a me nā shampoos.
Kahua lāʻau lapaʻau: hoʻohana ʻia ma ke ʻano he mea hoʻopili, mānoanoa a me ka suspending agent no nā papa lāʻau lapaʻau.
1.3 Nā pono a me nā pōʻino
Pōmaikaʻi: hiki ke hoʻoheheʻe wai maikaʻi, kūpaʻa kemika, ākea pH adaptability a me ka mea ʻole.
Nā pōʻino: hiki ke hoʻoheheʻe maikaʻi ʻia i kekahi mau mea hoʻoheheʻe, a ʻoi aku ke kiʻekiʻe o ke kumukūʻai ma mua o kekahi mau cellulose ethers.
2. Hoʻohālikelike i nā ether cellulose ʻē aʻe
2.1 Hydroxypropyl methylcellulose (HPMC)
2.1.1 Hoʻolālā a me nā waiwai
Hana ʻia ka HPMC mai ka cellulose ma o ka methylation a me ka hydroxypropylation reactions. Aia i loko o kona hale nā pani methoxy (-OCH3) a me ka hydroxypropoxy (-OCH2CH (OH) CH3).
Hoʻoheheʻe wai: Hoʻoheheʻe ʻia ka HPMC i ka wai anuanu e hana i kahi hopena colloidal akaka; ʻilihune kona hoʻoheheʻe ʻana i ka wai wela.
Waiwai mānoanoa: Loaʻa iā ia ka mana mānoanoa maikaʻi loa.
Nā waiwai gelling: Hana ia i gel i ka wā i wela ai a hoʻi i kona ʻano kumu i ka wā i maʻalili.
2.1.2 Nā wahi noi
Nā mea kūkulu hale: Hoʻohana ʻia ia ma ke ʻano he mānoanoa a me ka mea mālama wai no nā mea hana sima a me ka gypsum.
Meaʻai: Hoʻohana ʻia ia e like me ka emulsifier a me ka stabilizer.
Lapaʻau: Hoʻohana ʻia ia ma ke ʻano he excipient no nā capsules pharmaceutical a me nā papa.
2.1.3 Nā pono a me nā pōʻino
Pōmaikaʻi: ʻO ka hana mānoanoa maikaʻi a me nā waiwai gelling.
Nā pōʻino: He maʻalahi i ka wela a hiki ke hāʻule i nā noi wela kiʻekiʻe.
2.2 Methyl cellulose (MC)
2.2.1 Hana a me nā waiwai
Loaʻa ka MC ma o ka methylation o cellulose a loaʻa i ka methoxy (-OCH3) nā pani.
Hiki ke hoʻoheheʻe wai: hoʻoheheʻe maikaʻi ʻia i ka wai anuanu e hana i kahi hopena colloidal akaka.
Mānoanoa: he hopena mānoanoa nui.
ʻO ka hoʻoheheʻe wela: hana i ka gel i ka wā i hoʻomehana ʻia a me nā degels i ka wā i hoʻomaha ʻia.
2.2.2 Nā wahi noi
Nā mea kūkulu hale: hoʻohana ʻia ma ke ʻano he mānoanoa a me ka mālama wai no ka palaki a me ka pena.
Meaʻai: hoʻohana ʻia e like me ka emulsifier a me ka stabilizer.
2.2.3 Nā pono a me nā pōʻino
Pōmaikaʻi: hiki ke mānoanoa ikaika, hoʻohana pinepine ʻia i ka ʻenehana hana anu.
Nā pōʻino: ka wela wela, ʻaʻole hiki ke hoʻohana ʻia i nā wela kiʻekiʻe.
2.3 Hydroxypropyl cellulose (HPC)
2.3.1 Hoʻolālā a me nā waiwai
Loaʻa ka HPC e ka hydroxypropyl cellulose. Aia i loko o kona hale ka hydroxypropoxy (-OCH2CH(OH)CH3).
Hoʻoheheʻe wai: hoʻoheheʻe i ka wai anuanu a me nā mea hoʻoheheʻe organik.
Mānoanoa: hana mānoanoa maikaʻi.
Waiwai kiʻiʻoniʻoni: hana i kahi kiʻiʻoniʻoni ikaika.
2.3.2 Nā kahua noi
Lapaʻau: hoʻohana ʻia ma ke ʻano he mea uhi a me ka papa hoʻohui no nā lāʻau lapaʻau.
Meaʻai: hoʻohana ʻia e like me ka mānoanoa a me ka stabilizer.
2.3.3 Nā pono a me nā pōʻino
Pōmaikaʻi: multi-solvent solubility a me ka waiwai kiʻiʻoniʻoni maikaʻi loa.
Nā hemahema: ke kumu kūʻai kiʻekiʻe.
2.4 Carboxymethyl cellulose (CMC)
2.4.1 Hoʻolālā a me nā hiʻohiʻona
Hana ʻia ʻo CMC ma ka hana ʻana i ka cellulose me ka waikawa chloroacetic, a loaʻa i ka hui carboxymethyl (-CH2COOH) i loko o kona ʻano.
Hoʻoheheʻe wai: hiki ke hoʻoheheʻe ʻia i ka wai anuanu a me ka wai wela.
Waiwai mānoanoa: hopena mānoanoa nui.
Ionicity: no ka anionic cellulose ether.
2.4.2 Nā kahua noi
Meaʻai: hoʻohana ʻia e like me ka mānoanoa a me ka stabilizer.
Nā kemika o kēlā me kēia lā: hoʻohana ʻia e like me ka mānoanoa no ka mea holoi.
Ka hana pepa: hoʻohana ʻia i mea hoʻohui no ka uhi pepa.
2.4.3 Nā pono a me nā pōʻino
Pōmaikaʻi: maikaʻi mānoanoa a me ka laulā noi kahua.
Nā pōʻino: pili i nā electrolytes, hiki i nā ion i ka hopena ke hoʻopilikia i ka hana.
3. Hoʻohālikelike piha
3.1 Hana mānoanoa
He hana mānoanoa like ko HEC a me HPMC a he hopena mānoanoa maikaʻi nā ʻelua. Eia nō naʻe, ʻoi aku ka maikaʻi o ka hoʻoheheʻe wai ʻana o ka HEC a ua kūpono ia no nā noi e koi ana i ke aniani a me ka huhū haʻahaʻa. ʻOi aku ka maikaʻi o ka HPMC i nā noi e koi ana i ka hoʻomehana ʻana i ka gel ma muli o kāna mau waiwai thermogel.
3.2 Hoʻoheheʻe wai
Hiki ke hoʻoheheʻe ʻia ʻo HEC a me CMC i ka wai anuanu a me ka wai wela, ʻoiai ʻo HPMC a me MC e hoʻoheheʻe nui ʻia i ka wai anuanu. Makemake 'ia ka HPC i ka wā e koi 'ia ai ka ho'ohui like 'ana o ka multi-solvent.
3.3 Kumu kūʻai a me ka laulā noi
He mea maʻamau ke kumu kūʻai maʻamau a hoʻohana nui ʻia ʻo HEC. ʻOiai he hana maikaʻi loa ka HPC, hoʻohana maʻamau ia i nā noi kiʻekiʻe ma muli o kona kumukūʻai kiʻekiʻe. He wahi ko CMC i nā noi haʻahaʻa haʻahaʻa me kāna kumu kūʻai haʻahaʻa a me ka hana maikaʻi.
Ua lilo ʻo Hydroxyethyl cellulose (HEC) i hoʻokahi o nā cellulose ethers i hoʻohana nui ʻia ma muli o kona hoʻoheheʻe wai maikaʻi, kūpaʻa a me ka hiki ke mānoanoa. Hoʻohālikelike ʻia me nā cellulose ethers ʻē aʻe, loaʻa i ka HEC kekahi mau pono i ka hoʻoheheʻe wai a me ke kūpaʻa kemika, a kūpono ia no nā noi e koi ana i nā hoʻonā māmā a me ka adaptability pH ākea. ʻOi aku ka HPMC ma kekahi mau wahi kikoʻī ma muli o kona mānoanoa a me ka thermal gelling waiwai, ʻoiai ʻo HPC a me CMC e noho i kahi kūlana koʻikoʻi i kā lākou mau palapala noi ma muli o kā lākou mau waiwai hana kiʻiʻoniʻoni a me nā uku kumukūʻai. E like me nā koi noi kikoʻī, ke koho ʻana i ka cellulose ether kūpono hiki ke hoʻonui i ka hana huahana a me ke kumukūʻai.
Ka manawa hoʻouna: Jul-10-2024