Hydroxypropyl methylcellulose (HPMC) abu ne na polymer da aka saba amfani dashi a cikin shirye-shiryen magunguna.Saboda kyawawan halayensa na zahiri da sinadarai, yana taka muhimmiyar rawa wajen kera kwamfutar hannu.Ana iya amfani da HPMC azaman tsohon fim, wakili mai sarrafawa, m, mai kauri, da sauransu, yana ba da allunan tsari mai kyau da aiki.
1. Fim tsohon
Matsayin HPMC a matsayin tsohon fim yana nunawa a cikin rufin saman allunan sakin sarrafawa.Ana yin suturar kwamfutar hannu don manufar sarrafa yawan sakin kwayoyi, kare kwayoyi daga tasirin muhalli, da inganta bayyanar kwayoyi.A cikin shirye-shiryen saki da aka sarrafa, fim ɗin da HPMC ya kafa zai iya daidaita yawan sakin kwayoyi, tabbatar da cewa an fitar da kwayoyi a wasu sassa na gastrointestinal tract, kuma cimma sakamako mafi kyau na warkewa.
Hanyar aiwatarwa: Fim ɗin da tsohon fim ɗin HPMC ya kirkira zai iya samun nasarar sakin magunguna ta hanyar sarrafa shigar da abubuwan da ake amfani da su da kuma narkar da magunguna.Kauri da abun da ke ciki na fim ɗin na iya daidaita ƙimar rushewa don saduwa da buƙatun sakin kwayoyi daban-daban.
Tasiri: Allunan da ke amfani da HPMC a matsayin mai yin fim na iya narke sannu a hankali a cikin ciki, guje wa sakin miyagun ƙwayoyi kwatsam, inganta amfani da miyagun ƙwayoyi, da kuma rage ƙin ƙwayar ƙwayoyi zuwa gastrointestinal tract.
2. Wakilin saki mai sarrafawa
Yawancin lokaci ana amfani da HPMC azaman matrix abu a cikin allunan da aka sarrafa sarrafawa don daidaita yawan sakin kwayoyi ta hanyar kafa shingen gel.Matsayin wakili mai sarrafawa mai sarrafawa shine tabbatar da cewa an fitar da miyagun ƙwayoyi daidai da ƙayyadaddun lokaci don kula da tasiri mai tasiri na miyagun ƙwayoyi a cikin jiki, rage yawan adadin lokuta, da kuma inganta aikin haƙuri.
Tsarin aiki: A cikin kafofin watsa labarai masu ruwa da tsaki, HPMC na iya yin ruwa da sauri da samar da tsarin hanyar sadarwa na colloidal, wanda ke sarrafa yawan yaduwa da sakin magungunan.Lokacin da kwamfutar hannu ta haɗu da ruwa, HPMC yana sha ruwa kuma ya kumbura don samar da gel Layer, ta hanyar da miyagun ƙwayoyi ke yaduwa daga jiki, kuma adadin sakin ya dogara da kauri da yawa na gel Layer.
Tasiri: HPMC a matsayin wakili na sakewa mai sarrafawa zai iya daidaita adadin sakin miyagun ƙwayoyi, rage haɓakar ƙwayar ƙwayar ƙwayar jini, da kuma samar da ingantaccen sakamako na warkewa, musamman ga magunguna don maganin cututtuka na kullum.
3. Masu ɗaure
A cikin aiwatar da shirye-shiryen kwamfutar hannu, ana amfani da HPMC sau da yawa azaman mai ɗaure don haɓaka ƙarfin injina na allunan da tabbatar da amincin allunan yayin ajiya, sufuri da gudanarwa.
Hanyar aiki: HPMC, a matsayin mai ɗaure, na iya samar da haɗin gwiwa mai ƙarfi tsakanin barbashi, ta yadda foda ko ɓangarorin suna ɗaure kuma a kafa su cikin ƙaƙƙarfan kwamfutar hannu.Ana aiwatar da wannan tsari ta hanyar fasahar granulation rigar, inda HPMC ke narke a cikin wani bayani mai ruwa don samar da bayani mai danko, kuma ya samar da kwamfutar hannu mai tsayi bayan bushewa.
Tasiri: HPMC masu ɗaure na iya haɓaka ƙarfin matsawa da taurin allunan, rage haɗarin tarwatsewa ko rarrabuwa, don haka haɓaka inganci da kwanciyar hankali na allunan.
4. Masu kauri
HPMC kuma za a iya amfani da a matsayin thickener a ruwa shirye-shirye don daidaita rheological Properties na shirye-shirye da kuma ƙara danko.
Tsarin aiki: HPMC yana da babban danko a cikin ruwa kuma yana iya haɓaka dankowar ruwa yadda ya kamata, inganta dakatarwa da kwanciyar hankali na miyagun ƙwayoyi, da hana lalata.
Tasiri: Ƙara HPMC zuwa magungunan ruwa na iya inganta daidaituwar magungunan, sanya kayan aikin magani a rarraba daidai gwargwado a cikin shirye-shiryen, da tabbatar da daidaiton sashi kowane lokaci.
Halayen Hydroxypropyl Methylcellulose
1. Abubuwan Jiki da Sinadarai
HPMC ne nonionic cellulose ether tare da mai kyau ruwa solubility da thermal gelation.Yana narkewa da sauri a cikin ruwan sanyi don samar da bayani mai haske, yayin da lokacin zafi, maganin ya juya zuwa gel.
2. Biocompatibility
HPMC yana da kyawawa mai kyau da aminci, kuma ba shi da haɗari don haifar da amsawar rigakafi ko tasirin mai guba, don haka ana amfani dashi ko'ina a cikin magunguna da filayen abinci.
3. Zaman lafiyar muhalli
HPMC yana da kwanciyar hankali mai kyau ga abubuwan muhalli kamar zafin jiki da ƙimar pH, kuma ba shi da haɗari ga lalacewa ko raguwa, wanda ke tabbatar da kwanciyar hankali na shirye-shiryen miyagun ƙwayoyi a lokacin ajiya.
Misalai na aikace-aikacen HPMC a cikin Allunan
1. Allunan Sakin Sarrafa
Misali, a cikin allunan da aka ci gaba da sakin nifedipine da ake amfani da su don magance hauhawar jini, ana amfani da HPMC azaman matrix abu don sarrafa jinkirin sakin miyagun ƙwayoyi, rage yawan gudanarwa, da haɓaka bin haƙuri.
2. Allunan masu rufin ciki
A cikin allunan masu hana ruwa na proton pump inhibitors (kamar omeprazole), HPMC tana aiki azaman wakili mai yin fim don kare miyagun ƙwayoyi daga lalatawar acid na ciki da kuma tabbatar da cewa an fitar da maganin sosai a cikin hanji.
3. Allunan masu saurin narkewa na baka
A cikin allunan narkar da sauri na baka don maganin rashin lafiyan rhinitis, HPMC yana aiki azaman mai kauri da mannewa don samar da saurin rushewa da sakin uniform, haɓaka ɗanɗano da ɗaukar ƙwarewar miyagun ƙwayoyi.
Hydroxypropyl methylcellulose ana amfani da ko'ina a cikin shirye-shiryen daban-daban Allunan saboda da kyau kwarai film-kafa, sarrafawa saki, adhesiveness da thickening Properties.HPMC ba zai iya kawai inganta jiki Properties da kwanciyar hankali na Allunan, amma kuma inganta warkewa sakamako na kwayoyi ta daidaita da saki kudi na kwayoyi.Tare da haɓaka fasahar magunguna, aikace-aikacen HPMC zai zama mafi ɗimbin yawa, yana ba da ƙarin dama don haɓaka shirye-shiryen miyagun ƙwayoyi.
Lokacin aikawa: Yuni-27-2024