Methyl cellulose (MC) da hydroxypropyl methyl cellulose (HPMC) su ne nau'ikan cellulose guda biyu da ake amfani da su a masana'antu, gine-gine, magunguna, abinci da sauran filayen. Kodayake suna kama da tsari, suna da kaddarorin daban-daban kuma Akwai bambance-bambance masu mahimmanci a aikace-aikace da hanyoyin samarwa.
1. Bambance-bambance a tsarin sinadarai
Methylcellulose (MC) da hydroxypropylmethylcellulose (HPMC) duka an samo su ne daga cellulose na halitta kuma an gyare-gyaren sunadarai na cellulose ether mahadi. Amma bambancinsu ya ta'allaka ne a cikin nau'i da adadin ƙungiyoyin da suka maye gurbinsu.
Methyl cellulose (MC)
Ana samar da MC ta maye gurbin ƙungiyoyin hydroxyl akan cellulose tare da ƙungiyoyin methyl (watau -OCH₃). Tsarin sinadarai na MC ya ƙunshi ƙungiyoyi masu maye gurbin methyl akan babban sarkar cellulose, kuma adadin maye gurbinsa yana rinjayar solubility da kaddarorin sa. Gabaɗaya MC yana narkewa cikin ruwan sanyi amma ba cikin ruwan zafi ba.
Hydroxypropyl methylcellulose (HPMC)
An ƙara inganta HPMC akan methylcellulose, ta maye gurbin wani ɓangare na ƙungiyoyin hydroxyl tare da methyl (-CH₃) da hydroxypropyl (-CH₂CH (OH) CH₃). Idan aka kwatanta da MC, tsarin kwayoyin halitta na HPMC ya fi rikitarwa, hydrophilicity da hydrophobicity suna da daidaito sosai, kuma yana iya zama mai narkewa a cikin ruwan sanyi da ruwan zafi.
2. Bambance-bambance a cikin jiki da sinadarai Properties solubility
MC: Methylcellulose gabaɗaya yana da kyakkyawan narkewa a cikin ruwan sanyi, amma zai samar da gel lokacin da zafin jiki ya tashi. A cikin ruwan zafi, MC ya zama maras narkewa, yana samar da gel na thermal.
HPMC: Hydroxypropyl methylcellulose za a iya narkar da uniformly a cikin sanyi da kuma ruwan zafi, yana da fadi da narkar da zazzabi kewayon, da solubility ne mafi barga fiye da MC.
Thermal gelability
MC: MC yana da kaddarorin gelling thermal. Lokacin da zafin jiki ya tashi zuwa wani matakin, zai samar da gel kuma ya rasa narkewa. Wannan halayyar ta sa ta sami amfani na musamman a cikin masana'antar gini da magunguna.
HPMC: Har ila yau, HPMC yana da wasu kaddarorin gelling na thermal, amma yanayin halittar gel ɗin sa ya fi girma kuma saurin samuwar gel yana da hankali. Idan aka kwatanta da MC, HPMC's thermal gel Properties sun fi iya sarrafawa don haka sun fi fa'ida a aikace-aikacen da ke buƙatar kwanciyar hankali mai zafi.
Ayyukan saman
MC: MC yana da ƙananan aiki na ƙasa. Ko da yake ana iya amfani da shi azaman emulsifier ko kauri a wasu aikace-aikace, tasirin ba shi da mahimmanci kamar HPMC.
HPMC: HPMC yana da aiki mai ƙarfi na sama, musamman gabatarwar ƙungiyar hydroxypropyl, wanda ke ba da sauƙin emulsify, dakatarwa da kauri a cikin bayani. Sabili da haka, ana amfani dashi sosai azaman ƙari a cikin sutura da kayan gini.
Haƙurin gishiri da kwanciyar hankali na pH
MC: Methylcellulose yana da ƙarancin haƙurin gishiri kuma yana da saurin hazo a cikin mahalli mai gishiri. Yana da ƙarancin kwanciyar hankali a cikin yanayin acid da alkali kuma ƙimar pH yana tasiri cikin sauƙi.
HPMC: Saboda kasancewar maye gurbin hydroxypropyl, haƙurin gishiri na HPMC yana da kyau fiye da MC, kuma yana iya kula da solubility mai kyau da kwanciyar hankali a cikin kewayon pH mai faɗi, don haka ya dace da yanayin sinadarai daban-daban.
3. Bambance-bambance a cikin ayyukan samarwa
Samar da MC
Ana samar da Methylcellulose ta hanyar methylation reaction na cellulose, yawanci amfani da methyl chloride don amsawa tare da cellulose alkaline don maye gurbin kungiyoyin hydroxyl a cikin kwayoyin cellulose. Wannan tsari yana buƙatar sarrafa yanayin amsawa don tabbatar da matakin da ya dace na maye gurbin, wanda ke shafar solubility da sauran kaddarorin physicochemical na samfurin ƙarshe.
Samar da HPMC
Samar da HPMC ya dogara ne akan methylation kuma yana ƙara halayen hydroxypropylation. Wato, bayan methylation dauki na methyl chloride, propylene oxide reacts da cellulose don samar da wani hydroxypropyl madadin. Gabatarwar rukunin hydroxypropyl yana haɓaka iya narkewa da ƙarfin hydration na HPMC, wanda kuma ya sa tsarin samar da shi ya fi rikitarwa kuma ɗan ƙaramin tsada fiye da MC.
4. Bambance-bambance a cikin filayen aikace-aikacen
Filin kayan gini
MC: Ana amfani da MC sau da yawa a cikin kayan gini, musamman a matsayin mai kauri, mai riƙe ruwa da manne a busassun turmi da foda. Koyaya, saboda kaddarorin gelling ɗin sa na thermal, MC na iya gazawa a cikin yanayin zafi mai ƙarfi.
HPMC: An fi amfani da HPMC sosai a fagen gini. Saboda yana da kwanciyar hankali mai kyau a cikin yanayin zafi mai zafi, ya fi dacewa da yanayin yanayin da ke buƙatar haƙurin zafin jiki mai girma, irin su tile adhesives, insulation turmi da kuma matakin kai. .
Pharmaceutical da abinci filayen
MC: Methylcellulose ana yawan amfani dashi azaman mai tarwatsewa da kauri don allunan a cikin shirye-shiryen magunguna. Hakanan ana amfani dashi a wasu abinci azaman mai kauri da ƙarin fiber.
HPMC: HPMC yana da ƙarin fa'idodi a fagen magunguna. Saboda mafi kwanciyar hankali mai narkewa da kyakyawar yanayin halitta, ana amfani dashi sau da yawa a cikin abubuwan da aka ɗorawa na fim da harsashi na capsule don magunguna. Bugu da kari, ana amfani da HPMC sosai a cikin masana'antar abinci, musamman wajen kera capsules masu cin ganyayyaki.
Bangaren sutura da fenti
MC: MC yana da mafi kyawun kauri da tasirin fim, amma kwanciyar hankali da ikon daidaitawar danko a cikin mafita ba su da kyau kamar HPMC.
HPMC: HPMC ne yadu amfani a cikin Paint da Paint masana'antu saboda da kyau kwarai thickening, emulsification da kuma film-forming Properties, musamman a matsayin thickener da leveling wakili a cikin ruwa na tushen coatings, wanda zai iya muhimmanci inganta yi yi da kuma surface na shafi. . Tasiri.
5. Kariyar muhalli da aminci
Dukansu MC da HPMC an gyaggyara daga cellulose na halitta kuma suna da kyawawan abubuwan haɓakar halittu da kaddarorin kare muhalli. Dukansu ba su da guba kuma marasa lahani a amfani da su kuma suna bin ka'idodin kariyar muhalli, don haka suna da aminci sosai don amfani da su a fagen abinci, magunguna da kayan kwalliya.
Ko da yake methylcellulose (MC) da hydroxypropylmethylcellulose (HPMC) suna kama da tsarin sinadaran, saboda daban-daban substituent kungiyoyin, su solubility, thermal gelability, surface aiki, samar tsari da kuma aikace-aikace ne daban-daban. Akwai bambance-bambance a fili a fagage da sauran bangarorin. MC ya dace da yanayin ƙananan zafin jiki da sauƙi mai kauri da buƙatun riƙe ruwa, yayin da HPMC ya fi dacewa da aikace-aikacen masana'antu masu rikitarwa, magunguna da gine-gine saboda kyakkyawan narkewa da kwanciyar hankali na thermal.
Lokacin aikawa: Oktoba-25-2024