Hydroxypropyl Methylcellulose (HPMC) wani muhimmin polymer mai narkewa ne da ake amfani da shi sosai a cikin magunguna, abinci, sutura, kayan gini da sauran fannoni. Maganin danko na HPMC shine maɓalli mai mahimmanci wanda ke shafar aikinta da aikace-aikacensa, kuma zafin jiki yana da tasiri mai mahimmanci akan danko na maganin ruwa na HPMC.
1. Danko halaye na HPMC bayani
HPMC wani abu ne na polymer tare da kaddarorin narkar da thermally. Lokacin da aka narkar da HPMC a cikin ruwa, samar da maganin ruwa mai ruwa yana nuna halayen ruwan da ba na Newtonian ba, wato, dankon maganin yana canzawa tare da canje-canje a cikin ƙimar ƙarfi. A yanayin zafi na al'ada, maganin HPMC yakan kasance yana nuna alamun pseudoplastic, wato, suna da danko mafi girma a ƙananan ƙananan rates, kuma danko yana raguwa yayin da adadin shear ya karu.
2. Sakamakon zafin jiki akan danko na maganin HPMC
Canje-canjen yanayin zafi yana da manyan hanyoyin tasiri guda biyu akan danko na mafita na ruwa na HPMC: haɓaka motsin thermal na sarƙoƙi na ƙwayoyin cuta da canje-canje a cikin hulɗar mafita.
(1) Motsin thermal na sarƙoƙin ƙwayoyin cuta yana ƙaruwa
Lokacin da zafin jiki ya karu, motsi na thermal na sarkar kwayoyin HPMC yana ƙaruwa, wanda ke haifar da haɗin gwiwar hydrogen da van der Waals tsakanin kwayoyin don raunana da kuma yawan ruwa na maganin ya karu. Dankowar maganin yana raguwa saboda raguwar haɗuwa da haɗin kai ta jiki tsakanin sassan kwayoyin halitta. Saboda haka, HPMC ruwa mafita suna nuna ƙananan danko a yanayin zafi mafi girma.
(2) Canje-canje a cikin hulɗar bayani
Canje-canjen yanayin zafi na iya shafar narkewar ƙwayoyin HPMC a cikin ruwa. HPMC shi ne polymer tare da kaddarorin thermogelling, kuma solubility a cikin ruwa yana canzawa sosai tare da zafin jiki. A ƙananan yanayin zafi, ƙungiyoyin hydrophilic akan sarkar kwayoyin halitta ta HPMC suna samar da barga na hydrogen tare da kwayoyin ruwa, don haka suna riƙe da kyawawa mai kyau da ɗanko mai girma. Duk da haka, lokacin da zafin jiki ya tashi zuwa wani matakin, ana haɓaka hulɗar hydrophobic tsakanin sarƙoƙi na kwayoyin HPMC, wanda zai haifar da samuwar tsarin cibiyar sadarwa mai girma uku ko gelation a cikin bayani, yana haifar da dankon bayani ba zato ba tsammani ya karu a ƙarƙashin wasu yanayi. Ana kiran wannan al'amari Yana da wani abu "gel thermal".
3. Gwajin lura da zazzabi a kan HPMC bayani danko
Nazarin gwaji ya nuna cewa a cikin kewayon zafin jiki na al'ada (misali, 20 ° C zuwa 40 ° C), dankowar maganin ruwa na HPMC a hankali yana raguwa tare da ƙara yawan zafin jiki. Wannan shi ne saboda yanayin zafi mafi girma yana ƙara ƙarfin motsi na sarƙoƙi na kwayoyin halitta kuma yana rage hulɗar intermolecular, ta haka yana rage rikici na ciki na maganin. Duk da haka, lokacin da zafin jiki ya ci gaba da karuwa zuwa ma'aunin gel na thermal na HPMC (yawanci tsakanin 60 ° C da 90 ° C, dangane da matakin maye gurbin da nauyin kwayoyin halitta na HPMC), danƙon bayani ba zato ba tsammani yana ƙaruwa. Faruwar wannan al'amari yana da alaƙa da haɗaɗɗiyar juna da tara sarƙoƙin ƙwayoyin cuta na HPMC.
4. Dangantaka tsakanin zafin jiki da sigogi na tsarin HPMC
Maganin danko na HPMC ba kawai zafin jiki ya shafa ba, har ma yana da alaƙa da tsarin kwayoyin halitta. Misali, matakin maye gurbin (watau abun ciki na hydroxypropyl da methyl substituents) da nauyin kwayoyin halitta na HPMC suna da tasiri mai mahimmanci akan halayen gel na thermal. HPMC tare da babban mataki na maye gurbin yana kula da ƙananan danko a cikin kewayon zafin jiki mai faɗi saboda ƙarin ƙungiyoyin hydrophilic, yayin da HPMC tare da ƙaramin digiri na maye yana iya haifar da gels na thermal. Bugu da kari, HPMC mafita tare da mafi girma kwayoyin nauyi ne mafi kusantar ƙara a danko a high yanayin zafi.
5. Masana'antu da Ayyukan Aikace-aikacen Ayyuka
A aikace-aikace masu amfani, ana buƙatar zaɓar nau'in HPMC masu dacewa bisa ga takamaiman yanayin zafi. Misali, a cikin yanayin zafi mai zafi, HPMC tare da juriya mai girma yana buƙatar zaɓi don guje wa gelation na thermal. A ƙarƙashin ƙananan yanayin zafi, ana buƙatar la'akari da solubility da kwanciyar hankali na HPMC.
Tasirin zafin jiki akan danko na maganin ruwa na HPMC yana da mahimmancin aiki mai mahimmanci. A cikin fannin harhada magunguna, ana amfani da HPMC sau da yawa azaman kayan ci gaba mai ɗorewa don shirye-shiryen magunguna, kuma halayen ɗankowar sa kai tsaye suna shafar ƙimar sakin ƙwayoyi. A cikin masana'antar abinci, ana amfani da HPMC don haɓaka rubutu da kwanciyar hankali na samfuran, kuma dogaro da zafin jiki na ɗankowar maganinsa yana buƙatar daidaitawa gwargwadon zafin sarrafawa. A cikin kayan gini, ana amfani da HPMC azaman mai kauri da mai riƙe ruwa, kuma halayen ɗanɗanonta suna shafar aikin gini da ƙarfin kayan.
Tasirin zafin jiki akan danko na maganin ruwa na HPMC wani tsari ne mai rikitarwa wanda ya shafi motsin thermal na sarkar kwayoyin, hulɗar bayani, da kaddarorin tsarin polymer. Gabaɗaya, dankowar hanyoyin maganin ruwa na HPMC gabaɗaya yana raguwa tare da ƙara yawan zafin jiki, amma a wasu jeri na zafin jiki, gelation thermal na iya faruwa. Fahimtar wannan sifa yana da mahimmancin jagora don aikace-aikacen aikace-aikace da haɓaka tsari na HPMC.
Lokacin aikawa: Yuli-10-2024