Ethylcellulose wani abu ne na cellulose, polymer na halitta wanda ya ƙunshi raka'a glucose. Ana haɗe shi ta hanyar amsawa da amsawar cellulose tare da ethyl chloride ko ethylene oxide, yana samar da ƙwayoyin cellulose da aka maye gurbinsu. Ethylcellulose yana da kewayon abubuwan sinadarai waɗanda ke sa ya zama mai amfani a aikace-aikacen masana'antu da magunguna iri-iri.
Tsarin Kwayoyin Halitta:
Ethylcellulose yana riƙe da ainihin tsarin cellulose, wanda ya ƙunshi maimaita raka'o'in glucose wanda aka haɗa tare da haɗin β-1,4-glycosidic.
Sauya Ethyl yana faruwa da farko akan ƙungiyoyin hydroxyl na kashin bayan cellulose, wanda ke haifar da nau'ikan maye gurbin (DS) yana nuna matsakaicin adadin ƙungiyoyin ethyl a kowace naúrar glucose.
Matsayin maye gurbin yana rinjayar kaddarorin ethylcellulose, gami da solubility, danko, da ikon ƙirƙirar fim.
Solubility:
Saboda yanayin hydrophobic na rukunin ethyl, ethylcellulose ba shi da narkewa a cikin ruwa.
Yana nuna solubility a cikin nau'ikan kaushi na halitta, gami da alcohols, ketones, esters, da chlorinated hydrocarbons.
Solubility yana ƙaruwa tare da raguwar nauyin kwayoyin halitta da ƙara darajar ethoxylation.
Kaddarorin samar da fim:
Ethylcellulose an san shi da damar yin fim, yana sa ya zama mai mahimmanci a cikin samar da sutura, fina-finai, da tsarin sarrafa magunguna.
Ƙarfin ethylcellulose don narke a cikin nau'o'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in halitta yana inganta samar da fim, tare da zubar da ruwa na gaba yana barin fim mai kama da juna.
Reactivity:
Ethylcellulose yana nuna ƙarancin amsawa a ƙarƙashin yanayin al'ada. Koyaya, ana iya canza shi ta hanyar sinadarai ta hanyar halayen etherification, esterification, da haɗin kai.
Abubuwan haɓakawa sun haɗa da gabatarwar ƙarin abubuwan maye a kan kashin bayan cellulose, ta haka canza kaddarorin.
Esterification na iya faruwa ta hanyar amsa ethylcellulose tare da acid carboxylic ko acid chlorides, samar da esters cellulose tare da canza solubility da sauran kaddarorin.
Ana iya ƙaddamar da halayen haɗin kai don inganta ƙarfin inji da kwanciyar hankali na ethyl cellulose membranes.
Ayyukan thermal:
Ethylcellulose yana nuna kwanciyar hankali na thermal a cikin takamaiman kewayon zafin jiki, bayan abin da bazuwar ke faruwa.
Lalacewar thermal yawanci yana farawa a kusa da 200-250 ° C, ya danganta da dalilai kamar matakin maye gurbin da kasancewar filastik ko ƙari.
Thermogravimetric analysis (TGA) da bambancin sikanin calorimetry (DSC) ana amfani da dabaru da yawa don siffanta yanayin zafi na ethylcellulose da gaurayawan sa.
dacewa:
Ethylcellulose ya dace da wasu nau'ikan polymers, filastik da ƙari, yana sa ya dace da haɗuwa tare da sauran kayan don cimma abubuwan da ake so.
Abubuwan da ake amfani da su na yau da kullun sun haɗa da filastik kamar polyethylene glycol (PEG) da triethyl citrate, waɗanda ke haɓaka sassauƙa da abubuwan ƙirƙirar fim.
Daidaituwa tare da kayan aikin magunguna masu aiki (APIs) yana da mahimmanci a cikin ƙirƙira nau'ikan nau'ikan nau'ikan magunguna kamar tsawaita-saki Allunan da facin transdermal.
Ayyukan shamaki:
Fina-finan Ethylcellulose suna baje kolin kyawawan kaddarorin shinge ga danshi, iskar gas da tururin kwayoyin halitta.
Waɗannan kaddarorin shinge suna sa ethylcellulose ya dace da aikace-aikacen marufi inda kariya daga abubuwan muhalli ke da mahimmanci don kiyaye amincin samfur da rayuwar shiryayye.
Abubuwan Rheological:
Dankowar ethylcellulose mafita ya dogara da dalilai kamar tattarawar polymer, matakin maye gurbin, da nau'in sauran ƙarfi.
Maganin Ethylcellulose sau da yawa suna nuna halayen pseudoplastic, ma'ana cewa ɗankowar su yana raguwa tare da haɓaka ƙimar ƙarfi.
Nazarin rheological yana da mahimmanci don fahimtar halaye masu gudana na mafita na ethylcellulose yayin aiki da aikace-aikacen sutura.
Ethylcellulose wani nau'in polymer ne mai mahimmanci tare da nau'in sinadarai masu yawa waɗanda ke ba da gudummawa ga amfaninsa a cikin nau'o'in masana'antu da aikace-aikace na magunguna. Solubility, ikon yin fim, reactivity, kwanciyar hankali na thermal, dacewa, kaddarorin shinge da rheology sun sa ya zama abu mai mahimmanci don sutura, fina-finai, ƙirar sakin sarrafawa da marufi mafita. Ƙarin bincike da ci gaba a fagen abubuwan da suka samo asali na cellulose na ci gaba da fadada aikace-aikace da yuwuwar ethylcellulose a fannoni daban-daban.
Lokacin aikawa: Fabrairu-18-2024