Menene hypromellose phthalate?

Hypromloche Phthatara (HPMCP) wani nau'in compceututical comepical ne da ake amfani dashi a cikin tsarin kayan kwance, musamman wajen samar da allunan da aka ɗora da alamu da capsules. An samo shi daga cellulose, wanda shine polymer na halitta wanda ke samar da tsarin tsarin ganuwar kwayoyin halitta. HPMCP wani ruwa ne mai narkewa, polymer anionic wanda aka saba amfani dashi azaman kayan shafa mai shiga saboda kyawawan abubuwan ƙirƙirar fim, kwanciyar hankali, da juriya ga ruwan ciki.

An fara gabatar da HPMCP a farkon 1970s kuma tun daga lokacin ya zama kayan shafa mai yadu da ake amfani da shi saboda kaddarorin sa na musamman. An samar da shi ta hanyar esterification na hypromellose tare da phthalic acid kuma yana samuwa a cikin nau'i na nau'i daban-daban, dangane da matakin phthalation da nauyin kwayoyin halitta na polymer. Mafi yawan maki na HPMCP da ake amfani da su sune HPMCP-55, HPMCP-50, da HPMCP-HP-55, waɗanda ke da digiri daban-daban na phthalation kuma sun dace da amfani a cikin nau'ikan nau'ikan nau'ikan nau'ikan nau'ikan nau'ikan nau'ikan nau'ikan nau'ikan halitta.

Babban aikin HPMCP a cikin magungunan magunguna shine don kare abubuwan da ke aiki na miyagun ƙwayoyi daga lalacewa a cikin yanayin acidic na ciki. Lokacin da kwamfutar hannu ko capsule mai ɗauke da HPMCP ke ciki, rufin ya kasance cikakke a cikin ciki saboda ƙarancin pH, amma da zarar nau'in sashi ya isa mafi yanayin alkaline na ƙananan hanji, murfin ya fara narkewa kuma ya saki abubuwan da ke aiki. Wannan jinkirin sakin yana taimakawa wajen tabbatar da cewa an isar da miyagun ƙwayoyi zuwa wurin aiki kuma ba a lalata ingancinsa ta hanyar acid na ciki.