HPMC (Hydroxypyl methylcelrose) shine mafi yawan cirewa wanda aka yi amfani da shi wajen samar da siffofin sashi na magunguna iri-iri, gami da allunan, capsules, da samfuran ophththalmm. Ofaya daga cikin mahimman kaddarorin HPMC shine danko, wanda ke shafar kaddarorin samfurin ƙarshe. Wannan labarin zai bincika alaƙar da ke tsakanin HPMC kuma yana haskaka wasu matakan da yakamata a ɗauka lokacin amfani da wannan ceriod.
Dangantaka tsakanin HPMC ta danko da zazzabi
HPMC shine polymer na hydrophilic wanda yake da narkar da ruwa cikin ruwa da sauran abubuwan sha polhar. Lokacin da HPMC aka narkar da a cikin ruwa, yana samar da mafita ta viscous saboda babban kayan masarufi na polymer da babban digiri na lantarki. Gwajin HPMC mafita ya shafi abubuwa da yawa, gami da maida hankali kan polymer, zazzabi na maganin, da kuma ph na sauran ƙarfi.
Ofaya daga cikin mahimman abubuwan da suka shafi danko na maganin HPMC shine zazzabi. Maganin HPMC mafita yana raguwa tare da ƙara yawan zafin jiki. Wannan saboda a yanayin zafi mafi girma, sarƙoƙi na polymer ya zama mafi yawan ruwa, wanda ya haifar da karancin sojojin da ke riƙe da sarƙoƙin polymer tare. A sakamakon haka, danko na maganin yana raguwa kuma ruwan sha na maganin yana ƙaruwa.
Dangantaka tsakanin zafin jiki da HPMC na HPMC za a iya bayanin su ta hanyar daidaituwa na Arrhenius. Halin Arrhenius daidai ne na lissafi wanda ke bayyana alaƙar da ke tsakanin nauyin sunadarai da zazzabi na tsarin. Don mafita hpmc, ana iya amfani da daidaituwa na Arrheny don bayyana alaƙar da ke tsakanin danko da zazzabi tsarin.
An ba da daidaituwa ta Arrhenius by:
K = AE ^ (- EA / RT)
Inda k shine da ƙima mai sauƙi, a shine mafi girman iko, EA ita ce makamashin kunnawa, r shine kullun, kuma t shine zafin jiki na tsarin. HPMC mafita yana da alaƙa da ragin da ke gudana ta hanyar polymer na polymer, wanda aka sarrafa ta hanyar daidai da ƙa'idar halayen sunadarai. Sabili da haka, ana iya amfani da daidaituwa na Arrheny don bayyana alaƙar da ke tsakanin danko da zazzabi na tsarin.
Abubuwa don lura lokacin amfani da HPMC
Lokacin aiki tare da HPMC, yakamata a dauki matakan da yawa don tabbatar da aminci da ingancin kula da polymer. Wadannan ayyukan sun hada da:
1. Yi amfani da kayan kariya
Yana da mahimmanci a yi amfani da kayan aikin kariya kamar safofin hannu, goggles, da kuma riguna lab lokacin ɗaukar hpmc. Wannan saboda hpmc na iya haushi fata da idanu, kuma zai iya haifar da matsalolin idan sha. Saboda haka, yana da mahimmanci a ɗauki matakai don rage haɗarin bayyanar da polymers.
2. Ajiye hpmc daidai
HPMC ya kamata a adana a cikin sanyi, busasshen wuri don hana sha sha da danshi a cikin iska. Wannan saboda hpmc shine hygroscopic, ma'ana yana cike danshi danshi daga yanayinta kewaye. Idan hpmc ya sha danshi mai yawa danshi, zai iya shafar danko da kaddarorin samfurin karshe.
3. Kula da maida hankali da zazzabi
A lokacin da formulating tare da HPMC, tabbatar da kula da maida hankali da zazzabi na mafita. Wannan saboda danko na HPMC mafita ana ƙaddara shi sosai da waɗannan abubuwan. Idan taro ko zazzabi ya yi yawa ko yayi ƙasa, zai shafi danko da kaddarorin na ƙarshe.
4. Yi amfani da hanyoyin sarrafa abubuwan da suka dace
Lokacin aiki HPMC, yana da mahimmanci a yi amfani da hanyoyin sarrafawa da ya dace don tabbatar da aminci da ingancin sarrafa polymer. Wannan na iya haɗawa da amfani da hanyoyin haɗaɗɗun hanyoyin haɗi don hana sareding polymer ko rushewa, ko kuma amfani da dabarun bushewa da ya dace don cire daskararren danshi daga samfurin ƙarshe.
5. Bincika karfinsu
Lokacin amfani da HPMC a matsayin complifies, yana da mahimmanci a bincika dacewa tare da wasu cirewa da kayan aiki masu aiki a cikin tsari. Wannan saboda HPMC na iya hulɗa tare da wasu sinadarai a cikin tsari, yana shafar wasan kwaikwayon da kwanciyar hankali na samfurin ƙarshe. Saboda haka, yana da mahimmanci a gudanar da karatun daɗaɗe don gano kowane irin maganganu kafin ci gaba da tsari.
A ƙarshe
Dalili na HPMC mafita ya shafi abubuwa da yawa, gami da taro, zazzabi, da ph. Dangarin Magana HPMC yana raguwa da ƙara yawan zafin jiki saboda ƙara yawan motsi na polymer sarƙoƙi. Lokacin aiki tare da HPMC, yana da mahimmanci a dauki matakan da suka dace don tabbatar da amincin polymer. Wadannan ayyukan sun hada da yin amfani da kayan kariya, tana daukar nauyin HPMC, da fatan da suka dace da daidaitattun hanyoyin sarrafawa, da kuma daukar karfinsu da sauran sinaddi a cikin tsari. Ta hanyar daukar wadannan matakan, za a iya amfani da HPMC azaman ingantaccen tsayawa a cikin nau'ikan magunguna daban-daban.
Lokaci: Satumba 25-2023