Pharmaceutical Grade Hydroxypropyl Methylcellulose (HPMC) kayan aikin magunguna ne da aka saba amfani da shi, ana amfani da shi sosai a masana'antar harhada magunguna. Yana da Semi-synthetic, inert, cellulose ether mai narkewa da ruwa, wanda aka gyara ta hanyar sinadarai daga cellulose na halitta. HPMC yana da kyau film-forming, thickening, mannewa, dakatar da anti-caking Properties, don haka yana da muhimmanci aikace-aikace darajar a Pharmaceutical shirye-shirye.
1. Abubuwan asali na HPMC
Ana yin HPMC ta hanyar maye gurbin ɓangaren hydroxyl na cellulose tare da hydroxypropyl da ƙungiyoyin methoxy. Tsarin kwayoyin halittarsa ya ƙunshi abubuwan maye biyu, hydroxypropyl da methyl, don haka ana kiranta hydroxypropyl methylcellulose. HPMC yana da kyawawa mai narkewa a cikin ruwa, kuma bayan narkar da shi, yana samar da bayani mai haske. Yayin da maida hankali ya karu, danko kuma yana ƙaruwa. Bugu da ƙari, HPMC yana da kyakkyawar kwanciyar hankali na thermal da kwanciyar hankali na sinadarai, kuma yana da kyakkyawar juriya ga maganin acid, alkali da gishiri.
2. Aikace-aikacen HPMC a cikin magunguna
Ana amfani da HPMC sosai a cikin masana'antar harhada magunguna, galibi ta fuskoki masu zuwa:
a. Rufin kwamfutar hannu
HPMC, a matsayin mai rufi abu ga Allunan, iya yadda ya kamata rufe sama da mummunan dandano na kwayoyi, inganta bayyanar da kwayoyi, kuma yana da danshi-hujja da anti-oxidation effects. Bugu da kari, zai iya tsawaita lokacin sakin kwayoyi a cikin sashin gastrointestinal, ta yadda za a sami ci gaba ko sarrafa tasirin sakin.
b. Thickers da kuma binders
Lokacin shirya suspensions, emulsions, capsules da sauran shirye-shirye, HPMC, a matsayin thickener da ɗaure, iya inganta kwanciyar hankali da kuma uniformity na shirye-shirye. A lokaci guda, HPMC kuma na iya haɓaka tauri da ƙarfin injina na allunan don tabbatar da cewa ba a saurin karye magungunan yayin samarwa da sufuri.
c. Shirye-shiryen sarrafawa da dorewar-saki
Ana amfani da HPMC sau da yawa a cikin sarrafawa-saki da ci gaba-saki shirye-shirye domin gel Layer da ya kafa zai iya hana ruwa daga shigar da kwamfutar hannu, ta yadda da narkewa da saki kudi na miyagun ƙwayoyi ana sarrafa yadda ya kamata. Ta hanyar daidaita danko da sashi na HPMC, ana iya sarrafa adadin sakin miyagun ƙwayoyi daidai, ana iya tsawaita lokacin aikin miyagun ƙwayoyi, kuma ana iya rage yawan adadin magunguna.
d. A matsayin filler
A cikin shirye-shiryen capsule, ana iya amfani da HPMC azaman filler don cika capsules mara kyau. Idan aka kwatanta da capsules na gelatin na al'ada, capsules na HPMC suna da fa'idar kasancewar tsire-tsire kuma ba su da sinadarai na dabba, don haka sun dace da masu cin ganyayyaki da marasa lafiya masu haramcin addini.
3. Tsaro na HPMC
A matsayin ma'ajin magunguna, HPMC yana da kyakkyawar dacewa da aminci. Ba a lalacewa ta hanyar enzymes masu narkewa a cikin jikin mutum kuma galibi ana fitar da shi daga jiki ta hanji, don haka ba ya shiga cikin tsarin metabolism na miyagun ƙwayoyi kuma baya haifar da sakamako mai guba. An yi amfani da HPMC sosai a cikin shirye-shiryen baka, na sama da na allura daban-daban kuma ana gane su ta hanyar pharmacopoeias a duk duniya.
4. Halayen kasuwa
Tare da ci gaba da ci gaban masana'antar harhada magunguna, buƙatun don ingancin magunguna da aminci kuma suna ƙaruwa. Saboda kaddarorinsa na zahiri da sinadarai na musamman da aminci mai kyau, HPMC yana da fa'idar aikace-aikacen sabbin shirye-shiryen magani. Musamman a fannonin sarrafawa-saki da shirye-shiryen ci gaba-saki, magungunan halittu da magunguna don yawan jama'a na musamman (kamar masu cin ganyayyaki), buƙatar HPMC za ta ci gaba da girma.
A matsayin mai ba da kayan aikin magunguna da yawa, matakin magunguna na hydroxypropyl methylcellulose ya taka muhimmiyar rawa a cikin masana'antar harhada magunguna kuma za a ci gaba da amfani da shi da haɓakawa a nan gaba.
Lokacin aikawa: Agusta-06-2024