Pharmaceutical Excipients Cellulose Ether

Halitta cellulose ether shine kalma na gaba ɗaya don jerinabubuwan da suka samo asali na cellulosesamar da dauki na alkali cellulose da etherifying wakili a karkashin wasu yanayi. Samfuri ne wanda ƙungiyoyin hydroxyl akan cellulose macromolecules an maye gurbinsu gaba ɗaya ko gaba ɗaya ta ƙungiyoyin ether. Ana amfani da ethers na cellulose sosai a fannin man fetur, kayan gini, sutura, abinci, magani, da sinadarai na yau da kullum. A fagage daban-daban, samfuran da suka dace da magunguna suna cikin tsaka-tsaki da babban fage na masana'antu, tare da ƙarin ƙima. Saboda tsananin buƙatun inganci, samar da ether-salon ether shima yana da wahala. Ana iya cewa ingancin samfuran magunguna na iya wakiltar ƙarfin fasaha na kamfanonin ether cellulose. Cellulose ether yawanci ƙara a matsayin blocker, matrix abu da thickener don yin ci-release matrix Allunan, ciki-mai narkewa shafi kayan, ci-release microcapsule shafi kayan, ci-release miyagun ƙwayoyi film kayan, da dai sauransu.

Sodium carboxymethyl cellulose:

Carboxymethyl cellulose sodium (CMC-Na) shine nau'in ether cellulose tare da mafi girma samarwa da amfani a gida da waje. Ita ce ether cellulose ionic da aka yi daga auduga da itace ta hanyar alkalization da etherification tare da chloroacetic acid. CMC-Na abu ne da aka saba amfani da shi na kayan aikin magunguna. Ana amfani da shi sau da yawa azaman mai ɗaure don shirye-shirye masu ƙarfi, wakili mai kauri, wakili mai kauri, da wakili mai dakatarwa don shirye-shiryen ruwa. Hakanan za'a iya amfani dashi azaman matrix mai narkewa da ruwa da kayan ƙirƙirar fim. Yawancin lokaci ana amfani da shi azaman kayan fim ɗin magani mai ɗorewa da ɗorewa-saki matrix kwamfutar hannu a cikin shirye-shiryen saki (sarrafawa).

Bugu da ƙari, sodium carboxymethylcellulose a matsayin magungunan magunguna, croscarmellose sodium kuma za a iya amfani da shi azaman kayan aikin magunguna. Croscarmellose sodium (CCMC-Na) samfurin carboxymethylcellulose ne wanda ba shi da ruwa wanda ba zai iya narkewa ba yana amsawa tare da wakili mai haɗin gwiwa a wani zafin jiki (40-80 ° C) ƙarƙashin aikin mai haɓakawa na inorganic acid da tsarkakewa. A matsayin wakili mai haɗin gwiwa, ana iya amfani da propylene glycol, succinic anhydride, maleic anhydride da adipic anhydride. Ana amfani da Croscarmellose sodium azaman mai rarrabawa ga allunan, capsules da granules a cikin shirye-shiryen baka. Ya dogara ga capillary da kumburi sakamako don tarwatse. Yana da kyau matsawa da karfi tarwatsewa. Nazarin ya nuna cewa kumburin digiri na croscarmellose sodium a cikin ruwa ya fi na masu rarrabuwar kawuna kamar su carmellose sodium mai ƙarancin maye da hydrated microcrystalline cellulose.

Methylcellulose:

Methyl cellulose (MC) ba-ionic cellulose ether ne wanda aka yi daga auduga da itace ta hanyar alkalization da methyl chloride etherification. Methylcellulose yana da kyakkyawan narkewar ruwa kuma yana da ƙarfi a cikin kewayon pH2.0 ~ 13.0. Ana amfani dashi sosai a cikin abubuwan haɓaka magunguna, kuma ana amfani dashi a cikin allunan sublingual, alluran intramuscular, shirye-shiryen ido, capsules na baka, dakatarwar baka, allunan baka da shirye-shirye na Topical. Bugu da ƙari, a cikin shirye-shiryen ci gaba-saki, MC za a iya amfani da shi azaman hydrophilic gel matrix ci gaba-saki shirye-shirye, na ciki-mai narkewa kayan shafa, ci gaba-saki microcapsule shafi kayan, ci-release miyagun ƙwayoyi film kayan, da dai sauransu.

Hydroxypropyl methyl cellulose:

Hydroxypropyl methylcellulose (HPMC) wani ether ne wanda ba na ionic ba wanda aka yi shi daga auduga da itace ta hanyar alkalization, propylene oxide da methyl chloride etherification. Ba shi da wari, marar ɗanɗano, mara guba, mai narkewa a cikin ruwan sanyi da gelled cikin ruwan zafi. Hydroxypropyl methylcellulose wani nau'in ether ne na cellulose da aka haɗe wanda samarwa, adadinsa da ingancinsa ya ƙaru cikin sauri a kasar Sin a cikin shekaru 15 da suka gabata. Har ila yau, yana daya daga cikin abubuwan da ake amfani da su na magunguna a gida da waje. shekaru na tarihi. A halin yanzu, aikace-aikacen HPMC yana nunawa a cikin abubuwa biyar masu zuwa:

Daya a matsayin mai ɗaure da tarwatsewa. A matsayin mai ɗaure, HPMC na iya yin maganin cikin sauƙin jika, kuma yana iya faɗaɗa ɗaruruwan lokuta bayan shayar da ruwa, don haka zai iya inganta ƙimar narkarwa ko ƙimar sakin kwamfutar. HPMC yana da danko mai ƙarfi, wanda zai iya haɓaka ɗanɗanon ɗanɗano da haɓaka damfarar albarkatun ƙasa tare da ƙwanƙwasa ko gasasshen rubutu. HPMC tare da ƙananan danko za a iya amfani da shi azaman ɗaure da tarwatsewa, kuma waɗanda ke da ɗanko mai ƙarfi za a iya amfani da su azaman ɗaure kawai.

Na biyu shine a matsayin kayan fitarwa mai dorewa da sarrafawa don shirye-shiryen baka. HPMC abu ne da aka saba amfani da shi na matrix hydrogel a cikin shirye-shiryen ɗorewa. Low-viscosity sa (5-50mPa·s) HPMC za a iya amfani da matsayin mai ɗaure, viscosifier da suspending wakili, da high-danko sa (4000-100000mPa·s) HPMC za a iya amfani da shirya gauraye abu Toshe wakili ga capsules, hydrogel matrix. Allunan da aka fadada-saki. HPMC yana narkewa a cikin ruwan ciki na ciki, yana da fa'idodin matsawa mai kyau, ingantaccen ruwa mai ƙarfi, ƙarfin ɗaukar magunguna mai ƙarfi, da halayen sakin miyagun ƙwayoyi waɗanda PH bai shafa ba. Yana da mahimmancin mahimmancin kayan ɗaukar ruwa na hydrophilic a cikin tsarin shirye-shiryen ci gaba mai ɗorewa kuma galibi ana amfani dashi azaman matrix na gel na hydrophilic da kayan shafa don shirye-shiryen ci gaba da ci gaba, da kuma kayan taimako don shirye-shiryen iyo na ciki da kuma shirye-shiryen fim ɗin da aka ci gaba.

Na uku shi ne a matsayin mai shafi mai samar da fim. HPMC yana da kyawawan kaddarorin yin fim. Fim ɗin da aka kirkira da shi bai dace ba, bayyananne kuma mai tauri, kuma ba shi da sauƙin tsayawa yayin samarwa. Musamman ga magungunan da ke da sauƙi don shayar da danshi kuma ba su da kwanciyar hankali, yin amfani da shi a matsayin keɓewar keɓewa zai iya inganta kwanciyar hankali na miyagun ƙwayoyi da kuma hana Fim ɗin yana canza launi. HPMC yana da ƙayyadaddun ƙayyadaddun danko iri-iri. Idan aka zaɓa da kyau, inganci da bayyanar allunan masu rufi sun fi sauran kayan. Matsayin da aka saba shine 2% zuwa 10%.

Na huɗu shine azaman kayan capsule. A cikin 'yan shekarun nan, tare da yawaitar barkewar cututtukan dabbobi a duniya, idan aka kwatanta da capsules na gelatin, capsules na kayan lambu sun zama sabon masoyin masana'antun magunguna da abinci. Kamfanin Pfizer na Amurka ya yi nasarar fitar da HPMC daga tsire-tsire na halitta da kuma tanadin capsules na kayan lambu na VcapTM. Idan aka kwatanta da na gargajiya gelatin m capsules, shuka capsules suna da abũbuwan amfãni daga m adaptability, babu hadarin giciye-linked halayen da high kwanciyar hankali. Adadin sakin miyagun ƙwayoyi yana da ɗan kwanciyar hankali, kuma bambance-bambancen mutum kaɗan ne. Bayan rarrabuwa a cikin jikin mutum, ba a tsotse shi kuma ana iya fitar da abin da ke cikin jiki. Dangane da yanayin ajiya, bayan babban adadin gwaje-gwaje, kusan ba ya raguwa a ƙarƙashin yanayin ƙarancin zafi, kuma kaddarorin harsashi na capsule har yanzu sun kasance barga a ƙarƙashin yanayin zafi mai ƙarfi, kuma alamomin capsules na shuka ba su shafi ƙarƙashin matsanancin ajiya ba. yanayi. Tare da fahimtar mutane game da capsules na tsire-tsire da kuma canza ra'ayoyin magungunan jama'a a gida da waje, kasuwa na buƙatar capsules na shuka zai girma cikin sauri.

Na biyar shine a matsayin wakili mai dakatarwa. Dakatar-nau'in ruwa shiri ne da aka saba amfani da asibiti sashi nau'i, wanda shi ne a iri-iri watsawa tsarin a cikin abin da insoluble m kwayoyi suna tarwatsa a cikin wani ruwa watsawa matsakaici. Zaman lafiyar tsarin yana ƙayyade ingancin shiri na dakatarwar ruwa. HPMC colloidal bayani zai iya rage m-ruwa interfacial tashin hankali, rage surface free makamashi na m barbashi, da kuma daidaita da iri-iri watsawa tsarin. Yana da kyakkyawan wakili mai dakatarwa. Ana amfani da HPMC azaman mai kauri don zubar da ido, tare da abun ciki na 0.45% zuwa 1.0%.

Hydroxypropyl Cellulose:

Hydroxypropyl cellulose (HPC) wani ether ne wanda ba na ionic cellulose wanda aka yi daga auduga da itace ta hanyar alkalization da propylene oxide etherification. HPC yawanci mai narkewa ne a cikin ruwa da ke ƙasa da 40 ° C da adadi mai yawa na kaushi na polar, kuma aikin sa yana da alaƙa da abun ciki na ƙungiyar hydroxypropyl da matakin polymerization. HPC na iya dacewa da magunguna daban-daban kuma yana da inertia mai kyau.

Low-masanya hydroxypropyl cellulose (L-HPC) ana amfani da shi azaman tarwatsa kwamfutar hannu da ɗaure. -HPC na iya inganta tauri da haske na kwamfutar hannu, kuma yana iya sa kwamfutar hannu ta tarwatse da sauri, inganta ingancin ciki na kwamfutar hannu, da haɓaka tasirin warkewa.

Ana iya amfani da babban maye gurbin hydroxypropyl cellulose (H-HPC) azaman mai ɗaure don allunan, granules, da granules masu kyau a cikin filin magunguna. H-HPC yana da kyawawan kaddarorin yin fim, kuma fim ɗin da aka samu yana da tauri da na roba, wanda za'a iya kwatanta shi da masu yin filastik. Za a iya ƙara haɓaka aikin fim ɗin ta hanyar haɗuwa tare da wasu ma'aikatan da ke jure danshi, kuma ana amfani dashi sau da yawa azaman kayan shafa na fim don allunan. Hakanan za'a iya amfani da H-HPC azaman kayan matrix don shirya allunan ci gaba na matrix, ɗorewa-saki pellets da kuma allunan ci gaba mai ɗorewa.

Hydroxyethyl cellulose

Hydroxyethyl cellulose (HEC) ba-ionic cellulose ether ne wanda aka yi daga auduga da itace ta hanyar alkalization da etherification na ethylene oxide. A fagen magani, HEC yafi amfani dashi azaman thickener, colloidal m wakili, m, dispersant, stabilizer, suspending wakili, film-forming wakili da ci gaba-saki abu, kuma za a iya amfani da Topical emulsions, man shafawa, ido saukad. Ruwan baka, m kwamfutar hannu, capsule da sauran nau'ikan sashi. An yi rikodin Hydroxyethyl cellulose a cikin Tsarin Pharmacopoeia/US na Amurka da Pharmacopoeia na Turai.

Ethyl cellulose:

Ethyl cellulose (EC) yana ɗaya daga cikin abubuwan da aka fi amfani da su na cellulose na ruwa wanda ba zai iya narkewa ba. EC ba mai guba ba ce, barga, maras narkewa a cikin ruwa, acid ko alkali bayani, kuma mai narkewa a cikin kaushi na halitta kamar ethanol da methanol. Maganin da aka saba amfani dashi shine toluene/ethanol azaman 4/1 (nauyi) gauraye da ƙarfi. EC yana da amfani da yawa a cikin shirye-shiryen ɗorewa-saki, ana amfani da ko'ina azaman masu ɗaukar hoto, microcapsules, da kayan ƙirƙirar fim don shirye-shiryen ci gaba, kamar masu hanawa na kwamfutar hannu, adhesives, da kayan shafa na fim, ana amfani da su azaman fim ɗin kayan matrix don shirya. daban-daban nau'ikan allunan ci gaba na matrix, waɗanda aka yi amfani da su azaman gaurayawan abu don shirya shirye-shiryen ci gaba mai ɗorewa, ɗorewa-saki pellets, kuma ana amfani da su azaman kayan taimako na encapsulation don shirya ɗorewa-saki microcapsules; Hakanan za'a iya amfani dashi ko'ina azaman kayan jigilar kaya Don shirye-shiryen tarwatsewa mai ƙarfi; yadu amfani da Pharmaceutical fasahar a matsayin fim-forming abu da kuma kariya shafi, kazalika da ɗaure da filler. A matsayin kariya mai kariya na kwamfutar hannu, zai iya rage jin dadin kwamfutar hannu zuwa zafi kuma ya hana maganin miyagun ƙwayoyi daga danshi, canza launi da lalacewa; Hakanan zai iya samar da layin gel mai saurin sakin layi, microencapsulate da polymer, kuma yana ba da damar ci gaba da sakin tasirin miyagun ƙwayoyi.