HPMC a cikin Pharmaceuticals

The Pharmaceutical excipient hydroxypropyl methyl cellulose (HPMC) ne wanda ba ionic cellulose ether excipients, a halin yanzu shi ne mafi girma a cikin gida da waje amfani da magani excipients - a, a matsayin magani excipient yana da fiye da shekaru 30 na tarihi. Yana da wari, m, ba mai guba, mai narkewa a cikin ruwan sanyi, gelation a cikin ruwan zafi, low danko matakin HPMC za a iya amfani da matsayin m, stickiness wakili da kuma dakatar wakili high danko matakin HPMC za a iya amfani da shirya gauraye kayan tsarin ci-saki-saki. Allunan, ɗorewa-saki capsules, hydrophilic gel tsarin ci gaba-saki Allunan blocker, sarrafawa saki wakili da pore tashar wakili.

Kayayyakin kayan aikin magunguna suna nufin abubuwan da ake amfani da su a cikin samarwa da rarraba magunguna. Wani abu, ban da kayan aiki mai aiki, wanda aka kimanta da kyau don aminci kuma an haɗa shi a cikin samfurin magunguna. Magungunan magunguna suna da ayyuka masu mahimmanci na solubilizing, taimakawa rushewa, jinkirin da sarrafawa da sarrafawa ban da kafawa, cika masu ɗaukar kaya da inganta kwanciyar hankali, wanda zai iya rinjayar inganci, aminci da tasiri na kwayoyi.

Hydroxypropyl methyl cellulose HPMC yana daya daga cikin manyan abubuwan da ake amfani da su na magunguna a gida da waje, wanda aka yi amfani da shi azaman kayan aikin magani na shekaru. Ba shi da wari, mara daɗi kuma mara guba, mai narkewa a cikin ruwan sanyi da gelatinous a cikin ruwan zafi. HPMC a matsayin na halitta hydrophilic polymer Pharmaceutical kayan karin kayan, ba kawai za a iya amfani da a matsayin kwamfutar hannu, granule, kwaya m da disintegrant, fim shafi abu, kuma za a iya amfani da azaman colloidal wakili da kuma dakatar wakili, jinkirin saki da kuma sarrafa saki shiri blocker, sarrafawa. wakili na saki da wakili na yin pore, da kuma mai ɗaukar ƙwaƙƙwaran watsawa.

HPMC a matsayin mai ɗaure da tarwatsawa. HPMC a matsayin mai ɗaure na iya rage kusurwar lamba na kwayoyi, don haka magunguna suna da sauƙin jika, kuma ruwan nasa na iya faɗaɗa ɗaruruwan lokuta, don haka yana iya inganta narkewa ko sakin allunan. HPMC yana da ƙarfi danko, don rubutun kintsattse ko gasassun kayan albarkatun ƙasa na iya haɓaka ɗanɗanon ɗanɗanonta, haɓaka ƙarfinsa. Ana iya amfani da ƙananan danko na HPMC azaman mai ɗaure da tarwatsawa, babban danko kawai azaman mai ɗaure, adadin ya bambanta bisa ga ƙirar da buƙatun, babban adadin shine 2% -5%.

Ana amfani da HPMC azaman kayan saki mai sarrafawa don shirye-shiryen baka. HPMC abu ne na tsarin hydrogel da aka saba amfani dashi a cikin shirye-shiryen ɗorewa. HPMC da low danko matakin (5 ~ 50mPa • s) za a iya amfani da a matsayin mai ɗaure, m-haɓaka wakili da dakatar da taimako, yayin da HPMC da high danko matakin (4000 ~ 100000mPa • s) za a iya amfani da shirya gauraye kayan tsarin ci-saki-saki. Allunan, capsules mai dorewa, tsarin gel na hydrophilic ci gaba-saki Allunan azaman blocker. HPMC za a iya narkar da a cikin ciki enteric ruwa, yana da abũbuwan amfãni daga mai kyau pressability, mai kyau fluidity, da karfi da miyagun ƙwayoyi loading ikon da miyagun ƙwayoyi saki halaye ba su shafi pH, da dai sauransu, shi ne mai matukar muhimmanci hydrophilic m abu a cikin ci gaba da shirye-shirye tsarin, yawanci. amfani da matsayin hydrophilic gel tsarin da shafi abu na ci saki shirye-shirye, da kuma amfani da ciki iyo shirye-shiryen, ci gaba saki miyagun ƙwayoyi film wakili excipients.

HPMC a matsayin shafi film kafa wakili. HPMC yana da kyau film forming, shi Forms wani m film, m, samar ba sauki tsaya, musamman ga sauki danshi sha, m kwayoyi, tare da shi a matsayin kadaici Layer iya ƙwarai inganta zaman lafiyar da kwayoyi, hana fim discoloration. Idan aka kwatanta da samuwar fim ɗin gelatin, fim ɗin HPMC yana da daidaituwa mai kyau da watsa haske. HPMC yana da ƙayyadaddun ƙayyadaddun danko iri-iri, zaɓin da ya dace, ingancin shafi, bayyanar yana da kyau fiye da amfani da sauran kayan, taro da aka saba amfani dashi na 2% -10%.

HPMC a matsayin wakili na dakatarwa. Dakatar da ruwa shirye-shirye yawanci amfani a asibiti sashi siffofin, waxanda suke da iri-iri watsawa tsarin na insoluble m kwayoyi a cikin ruwa watsawa kafofin watsa labarai. Zaman lafiyar tsarin yana ƙayyade ingancin da aka dakatar da shirye-shiryen ruwa. HPMC colloidal bayani iya rage m-ruwa dubawa tashin hankali, rage surface free makamashi na m barbashi, sabõda haka, da iri-iri watsawa tsarin o ƙarin tabbatar da zama barga, shi ne mai kyau dakatar wakili. Ana amfani da HPMC azaman mai kauri don zubar da ido, tare da abun ciki na 0.45% -1.0%.