HPMC don Rufin Fim

HPMC donRufin fim shine dabarar samar da fim na bakin ciki na polymer akan ingantaccen shiri. Misali, ana fesa wani Layer na kayan polymer mai tsayi daidai gwargwado a saman takardar fili ta hanyar fesa hanyar da za a samar da Layer fim na filastik da yawa microns, don cimma tasirin da ake so. Samuwar wannan Layer na fim a waje da kwamfutar hannu shine cewa kwamfutar hannu guda ɗaya tana manne da kayan shafa na polymer bayan wucewa ta wurin fesa, sannan kuma ya karɓi na gaba na kayan shafa bayan bushewa. Bayan maimaita mannewa da bushewa, an gama rufewa har sai an rufe dukkan farfajiyar shirye-shiryen gaba daya. Rufin fim ɗin fim ne mai ci gaba, kauri galibi tsakanin 8 zuwa 100 microns, wani nau'i na elasticity da sassauci, manne da saman ainihin.

A cikin 1954, Abbott ya samar da rukunin farko na zanen fina-finai na kasuwanci, tun daga wannan lokacin, tare da ci gaba da haɓakawa da cikar kayan aikin samarwa da fasaha, an fitar da kayan fim ɗin polymer, ta yadda fasahar suturar fim ta haɓaka cikin sauri. Ba wai kawai nau'i-nau'i iri-iri, adadi da ingancin ma'aikatan launi na launi sun karu da sauri ba, har ma nau'o'in, nau'i da halaye na fasaha na fasaha, kayan aiki na sutura da fim din da kuma suturar kwayoyin TCM sun haɓaka sosai. Sabili da haka, aikace-aikacen fasahar suturar fim ya zama buƙatu da haɓaka haɓaka masana'antar harhada magunguna don haɓaka ingancin samfur.

Yin amfani da farko a cikin kayan aikin fim ɗin fim, har yanzu akwai babban adadin samfuran ta amfani da HPMChydroxypropyl methylcellulosea matsayin Membrane kayan. Shine tsarkakewaHPMCcellulose daga auduga lint ko ɓangaren litattafan almara, da sodium hydroxide bayani don nuna kumburi na alkali cellulose, sa'an nan tare da chloromethane da propylene oxide magani don samun methyl hydroxypropyl cellulose ether.HPMC, samfurin don cire ƙazanta bayan bushewa, murƙushewa, marufi. Gabaɗaya, ana amfani da ƙananan danko HPMC azamanfimshafi abu, da kuma 2% ~ 10% bayani da ake amfani da shafi bayani. Rashin hasara shi ne cewa danko yana da girma da yawa kuma fadada yana da karfi.

Ƙarni na biyu na kayan aikin fim shine polyvinyl barasa (PVA). Polyvinyl barasa yana samuwa ta hanyar alcoholysis na polyvinyl acetate. Ba za a iya amfani da raka'o'in maimaita barasa na Vinyl azaman masu amsawa ba saboda ba su cika adadi da tsabtar da ake buƙata don polymerization ba. A methanol, ethanol ko ethanol da methyl acetate gauraye bayani tare da alkali karfe ko inorganic acid a matsayin mai kara kuzari, hydrolysis ne m.

Ana amfani da PVA sosai a cikin suturar fim. Domin ba ya narkewa a cikin ruwa a yanayin zafi, gabaɗaya ana lulluɓe shi da rarrabuwar ruwa kusan kashi 20%. Ruwan tururi da iskar oxygen na PVA yana ƙasa da HPMC da EC, don haka ikon hana tururin ruwa da iskar oxygen ya fi ƙarfi, wanda zai iya kare tushen guntu mafi kyau.

Plasticizer yana nufin wani abu wanda zai iya ƙara yawan filastik kayan aikin fim. Wasu kayan aikin fim suna canza kaddarorinsu na zahiri bayan an rage yawan zafin jiki, kuma motsin macromolecules ɗin su ya zama ƙarami, yana sa rufin ya yi ƙarfi da karye, ba shi da sassaucin da ya dace, don haka sauƙin karyewa. An ƙara filastik don rage yawan zafin jiki na gilashin (Tg) da haɓaka sassaucin shafi. Plasticizers da aka saba amfani da su sune polymers amorphous tare da girman girman kwayoyin halitta da ƙaƙƙarfan alaƙa tare da kayan ƙirƙirar fim. Plasticizer maras soluble yana taimakawa wajen rage lalacewa na sutura, don haka ƙara kwanciyar hankali na shirye-shiryen.

An yi imani da cewa tsarin filastik shine cewa ƙwayoyin filastik suna cikin sarkar polymer, wanda ke toshe hulɗar tsakanin kwayoyin polymer zuwa babban matsayi. Haɗin kai yana da sauƙi lokacin da haɗin gwiwar polymer-plasticizer ya fi ƙarfin hulɗar polymer-plasticizer. Don haka, damar da za a yi wa sassan polymer don motsawa suna karuwa.

Ƙarni na uku na kayan ƙirƙirar fim shine filastik ta hanyar sinadarai da aka dasa a cikin fim ɗin samar da kayan polymer

Misali, sabon fim ɗin samar da kayan Kollicoat® IR wanda BASF ya gabatar shine cewa PEG ana dasa shi ta hanyar sinadarai zuwa dogon sarkar PVA polymer ba tare da ƙara filastik ba, don haka yana iya guje wa ƙaura daga tafkin bayan rufewa.