Shiri hydroxypropyl methylcellulose (HPMC) shafi mafita ya ƙunshi matakai da yawa kuma yana buƙatar kulawa da hankali ga daki-daki. HPMC ana amfani dashi azaman kayan shafa na fim a cikin masana'antar harhada magunguna da masana'antar abinci. Ana amfani da maganin sutura akan allunan ko granules don samar da kariya mai kariya, inganta bayyanar, da sauƙaƙe haɗiye.
1. Gabatarwa ga rufin HPMC:
Hydroxypropylmethylcellulose (HPMC) shine polymer na tushen cellulose wanda aka samo daga filaye na shuka. Saboda abubuwan samar da fina-finai da kauri, ana amfani da shi sosai a cikin suturar fim a cikin masana'antar harhada magunguna da abinci.
2. Abubuwan da ake buƙata:
Hydroxypropyl methylcellulose foda
Tsarkake ruwa
Kwantena filastik ko bakin karfe
Kayan aiki masu motsawa (misali Magnetic stirrer)
Kayan aunawa (ma'auni, silinda mai aunawa)
pH mita
Filastik ko bakin karfe kwanon rufi
Tanda mai zafi
3.Shirin:
Auna HPMC:
Daidai auna adadin da ake buƙata na foda HPMC dangane da tsarin da ake so. Abubuwan tattarawa yawanci tsakanin 2% zuwa 10%.
Shirya ruwa mai tsafta:
Yi amfani da ruwa mai tsabta don tabbatar da cewa ba shi da ƙazanta wanda zai iya rinjayar ingancin sutura. Ruwa ya kamata ya kasance a cikin zafin jiki.
Watsawa na HPMC:
A hankali ƙara foda HPMC da aka auna a hankali a cikin ruwa mai tsafta yayin da ake motsawa akai-akai. Wannan yana hana kumbura daga kafa.
Tada:
Haɗa cakuda ta amfani da injin maganadisu ko wasu na'urar motsa jiki masu dacewa har sai an tarwatsa foda na HPMC a cikin ruwa.
daidaita pH:
Auna pH na maganin HPMC ta amfani da mitar pH. Idan ya cancanta, ana iya daidaita pH ta ƙara ƙaramin adadin acid ko tushe daidai. Mafi kyawun pH don murfin fim yawanci yana cikin kewayon 5.0 zuwa 7.0.
Moisturizing da tsufa:
Ana ba da izinin maganin HPMC don yin ruwa da tsufa na wani takamaiman lokaci. Wannan yana haɓaka abubuwan ƙirƙirar fim. Lokacin tsufa na iya bambanta amma yawanci yana cikin kewayon awanni 2 zuwa 24.
tace:
Tace maganin HPMC don cire duk wani abu da ba a narkar da shi ko datti. Wannan mataki yana da mahimmanci don samun ingantaccen bayani mai laushi, bayyananne.
Daidaita danko:
Auna danko na maganin kuma daidaita shi zuwa matakin da ake so. Danko yana rinjayar daidaituwa da kauri na sutura.
Gwajin dacewa:
Gwada dacewa da maganin shafawa tare da substrate ( Allunan ko granules ) don tabbatar da mannewa da kyau da kuma samuwar fim.
Tsarin shafa:
Yi amfani da kwanon rufi mai dacewa kuma yi amfani da injin rufewa don amfani da maganin suturar HPMC zuwa allunan ko granules. Daidaita saurin tukunya da zafin iska don mafi kyawun sutura.
bushewa:
An bushe allunan da aka rufe ko granules a cikin tanda mai zafi mai sarrafa zafin jiki har sai an sami kauri da ake so.
QC:
Gudanar da gwajin kula da ingancin samfuran masu rufi gami da kamanni, kauri da kaddarorin narkar da su.
4.a qarshe:
A shirye-shiryen na HPMC shafi mafita ya ƙunshi jerin daidai matakai don tabbatar da inganci da tasiri na shafi. Riko da ƙayyadaddun hanyoyin da aka tsara da matakan kula da inganci yana da mahimmanci don samun daidaito da ingantaccen sakamako a cikin masana'antar harhada magunguna da abinci. Koyaushe bi Kyawawan Ayyuka na Masana'antu (GMP) da jagororin da ke da alaƙa yayin aikin shafa.
Lokacin aikawa: Janairu-18-2024