Hydroxypropylmethylcellulose (HPMC) polymer ne da aka samu daga cellulose wanda aka saba amfani dashi a masana'antu iri-iri, gami da magunguna, abinci, da gini. Zazzabi na iya yin tasiri mai mahimmanci akan aiki da hali na HPMC.
1. Narkewa da narkewa:
Solubility: HPMC yana nuna solubility mai dogaro da zafin jiki. Gabaɗaya, ya fi narkewa a cikin ruwan sanyi fiye da ruwan zafi. Wannan kadarorin yana da mahimmanci don ƙirar magunguna waɗanda ke buƙatar sakin magani mai sarrafawa.
Rushewa: Adadin narkar da tsarin HPMC yana shafar yanayin zafi. Yanayin zafi gabaɗaya yana haifar da rushewa cikin sauri, ta haka yana shafar sakin ƙwayar cuta a cikin aikace-aikacen magunguna.
2. Gelation da danko:
Gelation: HPMC na iya samar da gel a cikin bayani mai ruwa, kuma tsarin gelation yana shafar yanayin zafi. Gelation yawanci ana inganta shi a yanayin zafi mafi girma, yana haifar da samuwar cibiyar sadarwar gel.
Danko: Zazzabi yana taka muhimmiyar rawa wajen ƙayyade danko na mafita na HPMC. Gabaɗaya magana, haɓakar zafin jiki yana haifar da raguwar danko. Wannan kadarar tana da mahimmanci don ƙirƙira sutura, adhesives da sauran aikace-aikacen da ke buƙatar sarrafa danko.
3. Samuwar Fim:
Rufin fim: A cikin masana'antar harhada magunguna, ana amfani da HPMC sosai don murfin fim na allunan. Zazzabi yana rinjayar abubuwan samar da fim na mafita na HPMC. Yanayin zafi mafi girma na iya haɓaka tsarin samar da fim kuma yana shafar inganci da halaye na fim ɗin sutura.
4. Kwanciyar zafi:
Lalacewa: HPMC yana nuna kwanciyar hankali na zafi a cikin kewayon zazzabi. Bayan wannan kewayon, lalatawar thermal na iya faruwa, yana haifar da asarar danko da sauran kaddarorin da ake so. Dole ne a yi la'akari da kwanciyar hankali na thermal na HPMC a aikace-aikace daban-daban.
5. Canjin mataki:
Gilashin Canjin Canjin Canjin (Tg): HPMC yana jujjuya canjin gilashin a wani takamaiman zazzabi da ake kira zafin canjin gilashin (Tg). Sama da Tg, polymer yana canzawa daga gilashin gilashi zuwa yanayin rubbery, yana shafar kayan aikin injiniya.
6. Mu'amalar Drug-Polymer:
Haɗaɗɗen Ƙirƙirar: A cikin ƙirar magunguna, zafin jiki yana rinjayar hulɗar tsakanin HPMC da miyagun ƙwayoyi. Canje-canje a cikin zafin jiki na iya haifar da samuwar hadaddun, yana shafar narkewar ƙwayoyi da saki.
7. Tsarin tsari:
Daskare-Narke: Ana yawan amfani da HPMC a cikin daskararru, kamar daskararrun kayan zaki. sauye-sauyen yanayi yana shafar kwanciyar hankalin sa yayin daskarewa-narkewa. Fahimtar tasirin zafin jiki yana da mahimmanci don kiyaye ingancin samfur.
Zazzabi yana da tasiri mai mahimmanci akan solubility, rushewa, gelation, danko, samuwar fim, kwanciyar hankali na thermal, canje-canjen lokaci, hulɗar miyagun ƙwayoyi-polymer, da kuma samar da kwanciyar hankali na HPMC. Masu bincike da masu ƙira suna buƙatar yin la'akari a hankali waɗannan kaddarorin masu alaƙa da zafin jiki lokacin amfani da HPMC a aikace-aikace iri-iri.
Lokacin aikawa: Janairu-20-2024