Hydroxypropyl methylcellulose (HPMC) polymer ne da ake amfani da shi sosai a cikin shirye-shiryen magunguna, galibi ana amfani dashi don tsawaita lokacin sakin magunguna. HPMC wani yanki ne na cellulose na roba wanda ke da ruwa mai narkewa da kaddarorin samar da fim. Ta hanyar daidaita nauyin kwayoyin halitta, maida hankali, danko da sauran kaddarorin HPMC, ana iya sarrafa yawan sakin kwayoyi yadda ya kamata, ta yadda za a samu na dogon lokaci da ci gaba da sakin magunguna.
1. Tsarin da tsarin sakin magunguna na HPMC
HPMC ta samo asali ne ta hanyar hydroxypropyl da methoxy maye gurbin tsarin cellulose, kuma tsarin sinadarai yana ba shi kyakkyawan kumburi da kaddarorin fim. Lokacin da ake hulɗa da ruwa, HPMC yana saurin sha ruwa kuma yana kumbura don samar da gel Layer. Samuwar wannan gel ɗin gel ɗin yana ɗaya daga cikin mahimman hanyoyin sarrafa sakin ƙwayoyi. Kasancewar gel Layer yana iyakance ƙarin shigar da ruwa a cikin matrix na miyagun ƙwayoyi, kuma yaduwar miyagun ƙwayoyi yana hana shi ta hanyar gel Layer, ta haka yana jinkirta adadin sakin miyagun ƙwayoyi.
2. Matsayin HPMC a cikin shirye-shiryen ci gaba-saki
A cikin shirye-shiryen ɗorewa-saki, yawanci ana amfani da HPMC azaman matrix-saki mai sarrafawa. Ana tarwatsa ko narkar da maganin a cikin matrix na HPMC, kuma idan ya zo cikin hulɗa da ruwan ciki, HPMC ya kumbura kuma ya samar da gel Layer. Yayin da lokaci ya wuce, gel Layer yana karuwa a hankali, yana haifar da shinge na jiki. Dole ne a saki miyagun ƙwayoyi a cikin matsakaici na waje ta hanyar yaduwa ko yashwar matrix. Tsarin aikinsa ya ƙunshi abubuwa biyu masu zuwa:
Tsarin kumburi: Bayan HPMC ya shiga cikin hulɗa da ruwa, saman saman yana sha ruwa kuma yana kumbura don samar da gel ɗin viscoelastic. Yayin da lokaci ya wuce, a hankali Layer gel ɗin yana faɗaɗa ciki, Layer na waje ya kumbura kuma ya baje, kuma Layer na ciki ya ci gaba da samar da sabon gel Layer. Wannan ci gaba da kumburi da tsarin samuwar gel yana sarrafa adadin sakin miyagun ƙwayoyi.
Hanyar watsawa: Yaduwa da kwayoyi ta hanyar gel Layer wani muhimmin tsari ne don sarrafa adadin sakin. Gel Layer na HPMC yana aiki azaman shinge mai yaduwa, kuma magani yana buƙatar wucewa ta wannan Layer don isa matsakaicin in vitro. Nauyin kwayoyin halitta, danko da maida hankali na HPMC a cikin shirye-shiryen zai shafi kaddarorin gel Layer, ta haka ne ke daidaita yawan yaduwar miyagun ƙwayoyi.
3. Abubuwan da suka shafi HPMC
Akwai dalilai da yawa waɗanda ke shafar aikin sakin sarrafawa na HPMC, gami da nauyin kwayoyin halitta, danko, sashi na HPMC, kayan jiki da sinadarai na miyagun ƙwayoyi, da yanayin waje (kamar pH da ƙarfin ionic).
Nauyin kwayoyin halitta da dankowar HPMC: Girman nauyin kwayoyin halitta na HPMC, mafi girman dankowar gel Layer da rage saurin sakin miyagun ƙwayoyi. HPMC tare da babban danko na iya samar da Layer gel mai tauri, yana hana yawan yaduwar maganin, ta haka yana tsawaita lokacin sakin maganin. Sabili da haka, a cikin ƙirar shirye-shiryen ci gaba-saki, HPMC tare da ma'aunin kwayoyin halitta daban-daban da danko sau da yawa ana zaɓa bisa ga buƙatun don cimma tasirin sakin da ake sa ran.
Tattarawar HPMC: Matsalolin HPMC shima muhimmin abu ne wajen sarrafa adadin sakin miyagun ƙwayoyi. Mafi girma da maida hankali na HPMC, da kauri da gel Layer kafa, da girma da yaduwa juriya na miyagun ƙwayoyi ta hanyar gel Layer, da kuma sannu a hankali saki kudi. Ta hanyar daidaita adadin HPMC, lokacin sakin maganin ana iya sarrafa shi cikin sassauƙa.
Physicochemical Properties na kwayoyi: The ruwa solubility, kwayoyin nauyi, solubility, da dai sauransu na miyagun ƙwayoyi zai shafi ta saki hali a cikin HPMC matrix. Don magungunan da ke da ruwa mai kyau, miyagun ƙwayoyi na iya narke a cikin ruwa da sauri kuma ya yada ta hanyar gel Layer, don haka adadin sakin ya fi sauri. Don kwayoyi tare da rashin ruwa mara kyau, rashin ƙarfi yana da ƙananan, miyagun ƙwayoyi yana yaduwa a hankali a cikin gel Layer, kuma lokacin saki ya fi tsayi.
Tasirin yanayin waje: Abubuwan gel na HPMC na iya bambanta a cikin mahalli tare da ƙimar pH daban-daban da ƙarfin ionic. HPMC na iya nuna halayen kumburi daban-daban a cikin yanayin acidic, don haka yana shafar adadin sakin magunguna. Saboda manyan canje-canjen pH a cikin gastrointestinal tract na ɗan adam, halayen HPMC matrix ya ci gaba da shirye-shiryen sakewa a ƙarƙashin yanayi daban-daban na pH yana buƙatar kulawa ta musamman don tabbatar da cewa za'a iya fitar da miyagun ƙwayoyi a tsaye da ci gaba.
4. Aikace-aikacen HPMC a cikin nau'ikan shirye-shiryen sarrafawa-saki
Ana amfani da HPMC sosai a cikin shirye-shiryen ɗorewa-saki na nau'ikan sashi daban-daban kamar allunan, capsules, da granules. A cikin allunan, HPMC a matsayin matrix abu na iya samar da wani iri-iri na miyagun ƙwayoyi-polymer cakuda da kuma sannu a hankali saki da miyagun ƙwayoyi a cikin gastrointestinal fili. A cikin capsules, HPMC kuma galibi ana amfani da shi azaman membrane mai sarrafawa-saki don ɗaukar ɓangarorin miyagun ƙwayoyi, kuma ana sarrafa lokacin sakin maganin ta hanyar daidaita kauri da danko na Layer.
Aikace-aikace a cikin allunan: Allunan sune mafi yawan nau'in sashi na baka, kuma ana amfani da HPMC sau da yawa don cimma ɗorewa sakamakon sakin kwayoyi. Ana iya haɗa HPMC da magunguna kuma a matsa don samar da tsarin matrix iri ɗaya tarwatsa. Lokacin da kwamfutar hannu ta shiga cikin sashin gastrointestinal, saman HPMC ya yi sauri ya kumbura kuma ya samar da gel, wanda ke rage yawan rushewar miyagun ƙwayoyi. A lokaci guda, yayin da gel ɗin gel ya ci gaba da girma, ana sarrafa sakin magungunan ciki a hankali.
Aikace-aikace a cikin capsules:
A cikin shirye-shiryen capsule, yawanci ana amfani da HPMC azaman membrane mai sarrafawa mai sarrafawa. Ta hanyar daidaita abun ciki na HPMC a cikin capsule da kauri na fim ɗin shafa, za a iya sarrafa adadin sakin miyagun ƙwayoyi. Bugu da kari, HPMC yana da kyau solubility da biocompatibility a cikin ruwa, don haka yana da m aikace-aikace bege a capsule sarrafa saki tsarin.
5. Abubuwan ci gaba na gaba
Tare da ci gaban fasahar magunguna, aikace-aikacen HPMC ba kawai iyakance ga shirye-shiryen ci gaba ba, amma ana iya haɗa shi tare da wasu sabbin tsarin isar da magunguna, irin su microspheres, nanoparticles, da sauransu, don cimma daidaitattun sakin magunguna. Bugu da ƙari, ta ƙara gyaggyara tsarin HPMC, kamar haɗawa da wasu polymers, gyare-gyaren sinadarai, da dai sauransu, aikin sa a cikin shirye-shiryen sakin sarrafawa na iya ƙara ingantawa.
HPMC na iya tsawaita lokacin sakin magunguna yadda ya kamata ta hanyar tsarin kumburi don samar da gel Layer. Abubuwa kamar nauyin kwayoyin halitta, danko, maida hankali na HPMC da kaddarorin physicochemical na miyagun ƙwayoyi zasu shafi tasirin sakin sa mai sarrafawa. A aikace-aikace masu amfani, ta hanyar tsara yanayin amfani na HPMC bisa hankali, ana iya samun ci gaba da sakin nau'ikan magunguna daban-daban don biyan buƙatun asibiti. A nan gaba, HPMC yana da fa'idar aikace-aikace a fagen ɗorewar sakin ƙwayoyi, kuma ana iya haɗa shi da sabbin fasahohi don ƙara haɓaka haɓaka tsarin isar da magunguna.
Lokacin aikawa: Satumba-19-2024