Na farko, da Turanci gajarta kayan taimako
MC: Methyl cellulose
EC: ethyl cellulose
HPC: hydroxypropyl cellulose
HPMC: hydroxypropyl methylcellulose
CAP: Cellulose acetate phthalates
HPMCP: hydroxypropyl cellulose phthalates
HPMCAS: hydroxypropyl methyl cellulose acetate succinate
Cmc-na: sodium carboxymethyl cellulose
MCC: Microcrystalline cellulose
PVP: Povidone
PEG: polyethylene glycol
PVA: Polyvinyl barasa
Cms-na: sodium carboxymethyl sitaci
PVPP: Povidone mai haɗin gwiwa
CCNa: sodium carboxymethyl cellulose mai haɗin gwiwa
Na biyu, amfani da wasu kayan taimako
1. Lactose: kwamfutar hannu: filler, musamman foda kai tsaye filler;Allurar: lyophilized kariya
2. Microcrystalline cellulose: kwamfutar hannu: foda kai tsaye guga man kwamfutar hannu;"Busashen m";Allunan dauke da 20% microcrystalline cellulose aiki a matsayin disintegrators
3. Methyl cellulose: kwamfutar hannu: m;Wakilin dakatarwa: taimakon dakatarwa;Slow (sarrafawa) shirye-shiryen saki: hydrophilic gel kwarangwal abu (rauni)
4 sodium carboxymethyl cellulose: Allunan: m;Wakilin dakatarwa: taimakon dakatarwa;Slow (sarrafawa) shirye-shiryen saki: kayan kwarangwal na hydrophilic gel
5. Ethyl cellulose: kwamfutar hannu: m (marasa narkewa a cikin ruwa);Shirye-shiryen saki na jinkirin (sarrafawa): kayan kwarangwal ko kayan sarrafa membrane;m watsawa: insoluble m abu
6 hydroxypropyl cellulose: kwamfutar hannu: m, fim shafi abu;Wakilin dakatarwa: taimakon dakatarwa;Slow (sarrafawa) shirye-shiryen saki: hydrophilic gel kwarangwal abu, microporous membrane mai rufi takardar pore-inducing wakili
7. Hydroxypropyl methyl cellulose (hydroxypropyl methyl cellulose): kwamfutar hannu: m, kayan shafa fim;Wakilin dakatarwa: taimakon dakatarwa;Shirye-shiryen saki a hankali da sarrafawa: hydrophilic gel kwarangwal abu, microporous membrane mai rufi takardar pore-inducing wakili
8. Cellulose acetate phthalates: kayan ciki
9. Hydroxypropyl cellulose phthalates: kayan ciki
10. Hydroxypropyl cellulose acetate succinate: kayan ciki
11. Polyvinyl phthalate (PVAP): kayan ciki
12. Styrene Maleic acid copolymer (StyMA): kayan soluble na hanji
13. Acrylic resin (nau'in ciki na I, II, III), Eudragit L, Eudragit S (wani lokaci Eudragit L100 ko Eudragit S 100): kayan ciki
14.Eudragit RL, Eudragit RS: : Insoluble m abu
15.Eudragit E (daidai da acrylic IV): kayan abu na polymer mai narkewa
16. Cellulose acetate: ruwa insoluble abu, za a iya amfani da shafi ko shiri na osmotic famfo Allunan.
17. Polyvinylpyrrolidone (povidone PVP): allunan: adhesives;Tablet: kayan shafa fim mai narkewa mai narkewa;Pellets: nifedipine pellets (m watsawa);Wakilin dakatarwa: taimakon dakatarwa;
Watsawa mai ƙarfi: kayan ɗaukar ruwa mai narkewa;Slow (sarrafawa) shirye-shiryen saki: hydrophilic colloid kwarangwal abu;Slow (sarrafawa) shirye-shiryen saki: wakili mai haifar da pore a cikin allunan da aka rufe da microporous membrane
18. Polyvinyl barasa: wakilin fim: fim ɗin samar da kayan aiki, taimakon dakatarwa
19. sodium carboxymethyl sitaci: kwamfutar hannu: disintegrating wakili
20. Cross-linked povidone: Tablet: disintegrant
21. Crosslinked sodium carboxymethyl cellulose: kwamfutar hannu: disintegrating wakili
22. Low-masanya hydroxypropyl cellulose: Tablet: disintegrant
23. Polylactic acid: biodegradable polymer abu, amfani da shirye-shiryen na microspheres, nanoparticles, da dai sauransu
24. Glycerol (sorbitol propylene glycol yana aiki mafi kusa da glycerol).
Shirye-shiryen ruwa: ƙarfi, maganin allura, taimakon dakatarwa, moisturizer
Plasticizer a cikin capsule da kayan shafa
Maganin shafawa, tsarin isarwa transdermal: masu tallata shiga
Ƙara wettability na hydrophobic kwayoyi, osmotic matsa lamba regulator a cikin jijiya mai emulsion.
Glycerin gelatin (ga man shafawa, suppositories, m dispersions)
25. Glycerin gelatin
Kwayoyin zubar da ruwa: matrix mai narkewa mai ruwa
Suppository: matrix mai narkewa ruwa
Maganin shafawa: Ruwa mai narkewa matrix
26. Sodium dodecyl sulfate (anionic surfactant)
Emulsion, man shafawa: emulsifiers
Wakilin wetting don shirye-shirye masu ƙarfi / mai mai don allunan
mai solubilizer
27. Polyethylene glycol (PEG)
Allunan: Mai mai mai narkewa mai ruwa (PEG 4000, 6000)
Tablet: Plasticizer a cikin takardar sayan fim
Capsule: Soft capsule maras mai ruwa matsakaici (PEG 400)
Kwayoyin zubar da ruwa: Matrix mai narkewa mai ruwa (PEG 4000, 6000,9300)
Suppository: suppository matrix
Aerosol: Latent ƙarfi (PEG 400, 600)
Allura: Narke (PEG 400, 600)
Shirye-shiryen Liquid: Magani (PEG 400, 600)
m watsawa: m
Slow (sarrafawa) shirye-shiryen saki: wakili mai haifar da pore a cikin allunan da aka rufe da microporous membrane
Shirye-shiryen sha na percutaneous: transdermal absorption enhancer
28. Poloxam (" zwitterionic "surfactant) Abokin hulɗa mai hankali ya lura da rashin daidaituwa a nan, yanzu an gyara shi zuwa" Poloxam "maras ionic surfactant, ba zwitterionic surfactant!
M dispersion dispersioner, suppository matrix, emulsifier don allura ko jiko
Takaitaccen bayani na maganin antiseptik da bacteriostatic
Hydroxyl benzene ester (neper zinariya), benzoic acid, sodium benzoate, sorbic acid, benzalkonium bromide (sabon tsabta fita), benzalkonium chloride (jie er mutu), chlorhexidine acetate, benzyl barasa (na gida zafi) a lokaci guda, giciye-linked. tare da tertiary butyl barasa (ciwon gida) a lokaci guda, nitrobenzene, mercury, thimerosal, disinfection net, ortho-phenyl phenol, phenoxyethanol, eucalyptus man fetur, kirfa mai, ruhun nana mai, da dai sauransu.
Hudu, hanyar haifuwa
1/ Glucose allura, mai emulsion for intravenous allura, dextran, sodium chloride jiko, roba toshe da sauran zafi latsa haifuwa;
2/ allurar Vitamin C, allurar procaine hydrochloride, allurar cortisone acetate, chloramphenicol ido saukad an haifuwa ta hanyar zazzage tururi;
3 / Man allura, man shafawa matrix, ampoule ta amfani da hanyar haifuwa bushe bushe;
4 / Asepsis dakin iska, aiki tebur surface: ultraviolet sterilization hanya ko gas fumigation hanya;
5/ Hand, aseptic kayan aiki: sinadaran haifuwa Hanyar
6/ allurar insulin da sauran abubuwan halitta: hanyar tacewa
V. Ma'auni masu alaƙa
1. Noyes-whitney equation: ya bayyana adadin rushewar magunguna.
2. M dangi zafi na cakuda
hygroscopicity na P68 foda)
3. Farashin sauyawaP87)
4.Poiseuile dabara: bayyana abubuwan tasiri na tacewa (alurar P124)
5. Ƙididdigar ƙididdiga na ƙa'idar isotonic ta hanyar rage ma'ana mai daskarewaallura P156)
6. Lissafi na HLB darajar gauraye surfactantruwa P178)
Fasaha shirye-shirye masu dacewa
1. Microcapsule: Hanyar kwantar da hankali (guda ɗaya, hadaddun), hanyar da ba ta narkewa ba, hanyar canza yanayin zafin jiki, hanyar bushewa ta ruwa, hanyar bushewa, hanyar fesa ruwa, hanyar dakatarwar iska, hanyar samun iska mai ƙarfi, hanyar haɓakar iska, hanyar wucewa ta hanyar radiation
2. Kunshin hadawa: hanyar maganin ruwa mai cikakken ruwa, hanyar niƙa, hanyar bushewa daskarewa, hanyar bushewa ta fesa
3. M dispersions: narkewa Hanyar, sauran ƙarfi Hanyar, sauran ƙarfi - narkewa Hanyar, sauran ƙarfi - fesa bushewa Hanyar, nika hanya
4. Liposomes: hanyar allura, hanyar watsawa na fim na bakin ciki, Hanyar watsawa ta ultrasonic, Hanyar watsawa lokaci, hanyar bushewa daskarewa
5. Microspheres: emulsification - hanyar warkewa, hanyar bushewa ta fesa, hanyar bushewa ruwa
6. Nanoparticles: micellar polymerization, emulsion polymerization, interfacial polymerization, ruwa bushewa hanya
7. Pellet: tafasar granulation Hanyar, fesa granulation Hanyar, shafi tukunya hanya, extrusion sphericity hanya, centrifugal projectile Hanyar, ruwa bushewa Hanyar
8 suppository: Hanyar narkewa mai zafi, Hanyar latsa sanyi, hanyar durƙusa
9. Maganin shafawa: hanyar niƙa, hanyar narkewa, hanyar emulsification
Wakilin fim na 10: Hanyar samar da fim ɗin slurry, hanyar samar da fim mai narkewa, hanyar yin fim mai hade.
Bakwai, na'urorin haɗi na wakilci
1. Microcapsule: gelatin - Larabci danko
2. Hadawa fili: cyclodextrin
3. M watsawa: PEG, PVP
4. Liposomes: phospholipid-cholesterol
5. Microspheres: gelatin, albumin, PLA, da dai sauransu
6. Suppository: man koko
7. Maganin shafawa: Jelly, da dai sauransu
Wakilin fim 8: PVA
Takwas, lokaci kaɗan
1. Za a bar ampoule da aka haifuwa ba fiye da sa'o'i 24 ba;
2. Adana ruwa don allura bazai wuce sa'o'i 12 ba;
3. Za a kammala bakarawar allurar gabaɗaya a cikin sa'o'i 12 bayan tukunyar;
4. Jiko da shirye-shiryen bayani za a kammala a cikin sa'o'i 4 na haifuwa
9. Abubuwan dubawa masu inganci masu alaƙa da shirye-shiryen magunguna
1. Allunan: halayen bayyanar;Yanke bambancin nauyi;Tauri da gaggautsa;Digiri na tarwatsewa;Rushewa ko saki;Uniformity na abun ciki
2. Wakilin watsawa: daidaituwa;Danshi.Loading yawa bambanci;Gwajin lafiya;Binciken granularity
3. Granule: bayyanar;Girman barbashi;Rashin nauyi mai bushe;Narke;Bambancin lodi
4. Capsule: bayyanar;Danshi.Loading yawa bambanci;Rushewa da rushewa.
5. Sauke kwayoyi: bambancin nauyi;Binciken iyakar lokacin rushewa, da sauransu.
6. Suppository: bayyanar;Bambancin nauyi;Ƙayyadadden lokacin narkewa;Kewayon wurin narkewa;Gwajin narkar da in vitro da gwajin sha a cikin vivo
7. Filasta: girman barbashi;lodi;Iyakar ƙananan ƙwayoyin cuta;Babban abun ciki na miyagun ƙwayoyi;Kaddarorin jiki;Ƙarfafawa;Kwanciyar hankali;Saki, shiga da kuma sha da kwayoyi a cikin maganin shafawa.
8. Transdermal faci: bambancin nauyi;Bambancin yanki;Daidaitaccen abun ciki;Digiri na saki, da sauransu.
10. Ma'anoni daban-daban
1. Micro capsule: karamin capsule ne da aka samar ta hanyar nannade wani abu mai karfi ko ruwa (wanda ake kira capsule core) a cikin wani abu na halitta ko na roba (wanda ake kira capsule abu).1-5000 microns
2. Pellet: yana nufin mahaɗan mai siffar zobe tare da diamita ƙasa da 2.5mm wanda ya ƙunshi magunguna da abubuwan haɓakawa.
3. Microsphere: kwarangwal-type microscopic mahadi mahaluži kafa ta dissolving ko dispersive kwayoyi a cikin tsarin na polymer kayan, tare da barbashi size yawanci tsakanin 1 da 250μm.
4. Nanoparticles: m colloidal barbashi hada da polymeric abubuwa, tare da barbashi size a cikin kewayon 10 ~ 1000nm.
5. Dropping kwaya wakili: yana nufin m ko ruwa kwayoyi da kuma dacewa abubuwa (yawanci aka sani da matrix) dumama narkewa mix, drop a cikin miscible condensate, condensation condensation kuma Ya yi da kananan pellet shiri.
Lokacin aikawa: Satumba-09-2022