HPC (Hydroxypropyl Cellulose) da HPMC (Hydroxypropyl Methylcellulose) su ne nau'ikan cellulose guda biyu masu narkewa da ruwa da aka saba amfani da su a cikin masana'antar harhada magunguna, abinci da sinadarai. Ko da yake sun yi kama da wasu bangarori, tsarinsu na sinadarai, kaddarorinsu da yanayin aikace-aikacensu sun bambanta sosai.
1. Tsarin sinadaran
HPC: HPC wani bangare ne na hydroxypropylated na cellulose. Ana yin ta ta hanyar mayar da martani ga cellulose tare da propylene oxide da gabatar da ƙungiyoyin hydroxypropyl (-CH2CHOHCH3). A cikin tsarin HPC, wani ɓangare na ƙungiyoyin hydroxyl na kashin baya na cellulose an maye gurbinsu da ƙungiyoyin hydroxypropyl, suna mai da shi ruwa mai narkewa da thermoplastic.
HPMC: HPMC wani bangare ne na hydroxypropylated da methylated wanda aka samu na cellulose. An shirya shi ta hanyar gabatar da ƙungiyoyin hydroxypropyl da ƙungiyoyin methoxy (-OCH3) a cikin cellulose. Tsarin kwayoyin halitta na HPMC ya fi rikitarwa, tare da gabatarwar ƙungiyoyin hydroxypropyl da maye gurbin methyl.
2. Halin jiki da sinadarai
Solubility: Dukansu polymers ne masu narkewar ruwa, amma halayen rushewarsu sun bambanta. HPC yana da kyawawa mai kyau a cikin ruwan sanyi da wasu abubuwan kaushi (kamar ethanol, propanol, da sauransu), amma narkewar sa na iya raguwa a yanayin zafi (kimanin 45 ° C ko sama). HPMC yana da kyakkyawan narkewa a cikin ruwan sanyi, amma yana da kaddarorin gelling a cikin ruwan zafi mai zafi, wato, yawan zafin jiki, HPMC narkar da cikin ruwa zai samar da gel kuma ba zai ƙara narke ba.
Kwanciyar zafi: HPC yana da kyakkyawan thermoplasticity, wanda ke nufin yana iya yin laushi ko narke a yanayin zafi mafi girma, don haka ana amfani dashi sau da yawa a cikin kayan gyare-gyaren thermoplastic. HPMC yana da mafi girman juriya na zafi, ba shi da sauƙi don narkewa ko laushi, kuma ya dace da aikace-aikace a ƙarƙashin yanayin zafi mai girma.
Danko: HPMC yawanci yana da mafi girma danko fiye da HPC, musamman a cikin Pharmaceutical masana'antu, HPMC sau da yawa amfani a formulations cewa bukatar karfi bonding ko shafi, yayin da HPC da ake amfani da a yanayi inda matsakaici ko low danko ake bukata.
3. Filayen aikace-aikace
Filin magunguna:
HPC: HPC kayan haɓakar magunguna ne, galibi ana amfani dashi azaman mannen kwamfutar hannu, wakili mai ƙirƙirar fim ɗin harsashi, da kayan matrix don sakin magunguna. Saboda ta thermoplasticity, shi ma dace da wasu zafi narke tsari shirye-shirye. HPC kuma yana da kyawawa mai kyau da lalacewa, kuma ya dace da amfani azaman tsarin isar da magunguna na ciki.
HPMC: HPMC ne mafi yadu amfani a Pharmaceutical masana'antu, kuma ana amfani da sau da yawa azaman matrix abu, shafi abu, thickener da stabilizer for ci-saki Allunan. Abubuwan gelling na HPMC sun sa ya zama ingantaccen kayan sarrafa magunguna, musamman a cikin sashin gastrointestinal, inda zai iya sarrafa ƙimar sakin miyagun ƙwayoyi yadda ya kamata. Its kyau film-forming Properties kuma sanya shi babban zabi ga kwamfutar hannu shafi da barbashi shafi.
Filin abinci:
HPC: A cikin masana'antar abinci, ana iya amfani da HPC azaman thickener, stabilizer da emulsifier don inganta rubutu da bayyanar abinci. A wasu lokuta, ana iya amfani da shi azaman kayan fim ɗin da ake ci don wasu abinci waɗanda ke buƙatar kiyayewa ko ware.
HPMC: Hakanan ana amfani da HPMC azaman mai kauri, emulsifier da stabilizer a masana'antar abinci, musamman a cikin kayan da ake toyawa kamar burodi da kek. HPMC yana taimakawa inganta tsari da nau'in kullu da tsawaita rayuwar abinci. Bugu da kari, ana kuma amfani da HPMC sosai a cikin abinci masu cin ganyayyaki a matsayin madaidaicin tushen shuka don maye gurbin collagen na dabba.
Kayan shafawa da samfuran kulawa na sirri:
Dukansu HPC da HPMC ana iya amfani da su a cikin kayan kwalliya azaman masu kauri, masu daidaitawa da tsoffin fina-finai. Misali, ana iya amfani da su a cikin kulawar fata da samfuran gashi don haɓaka taɓawa da kwanciyar hankali na samfurin. HPMC yawanci ya fi dacewa a matsayin wakili na colloid na gaskiya, kamar mai kauri a cikin idon ido, yayin da ake amfani da HPC sau da yawa a yanayin da ake buƙatar samar da sutura mai sassauƙa.
Kayan gini da sutura:
HPMC: Saboda kyakkyawar mannewa da riƙewar ruwa, ana amfani da HPMC sosai a cikin kayan gini kamar su siminti, turmi, putty da gypsum don haɓaka mannewa da haɓaka aikin gini.
HPC: Sabanin haka, HPC ba ta da amfani a masana'antar gine-gine kuma galibi ana amfani da ita azaman ƙari ko manne don sutura.
4. Tsaro da kare muhalli
Dukansu HPC da HPMC ana ɗaukarsu ingantattun kayan lafiya kuma ana amfani da su sosai a abinci, magunguna da samfuran kulawa na sirri. Dukansu biyu suna da kyau biocompatibility da degradeability, kuma ba zai haifar da illa mai guba ga jikin mutum. Duk da haka, tun da ba su shiga cikin jikin mutum ba kuma ana amfani da su azaman kayan taimako kawai, yawanci ba su da tasiri a jikin mutum. Bugu da kari, tsarin samar da HPC da HPMC yana da matukar dacewa da muhalli, kuma sinadaran da sauran kaushi da ake amfani da su wajen samarwa za a iya sake yin amfani da su da kyau da kuma sake amfani da su.
Ko da yake HPC da HPMC duka abubuwan haɓakar cellulose ne kuma suna da aikace-aikacen giciye a wasu aikace-aikacen, suna da bambance-bambance masu mahimmanci a tsarin sinadarai, kaddarorin jiki da wuraren aikace-aikace. HPC ya fi dacewa da aikace-aikacen da ke buƙatar kayan aikin thermoplastic, irin su sakin magunguna da hanyoyin gyaran gyare-gyare masu zafi, yayin da ake amfani da HPMC a cikin magunguna, abinci, gine-gine da sauran filayen saboda kyakkyawar mannewa, kayan samar da fina-finai da riƙewar ruwa. . Don haka, wane kayan da za a zaɓa ya dogara da takamaiman buƙatun aikace-aikacen.
Lokacin aikawa: Oktoba-22-2024