Hydroxypropyl Methylcellulose (HPMC) Semi-synthetic ne, inert, polymer high-viscosity wanda aka yadu ana amfani dashi a cikin ƙirar ƙwayoyi. Kayayyakinsa na musamman na zahiri da na sinadarai sun sa ya zama maƙasudi mai mahimmanci a cikin masana'antar harhada magunguna, tare da ƙirƙirar fim, kauri, kwanciyar hankali da daidaituwa.
Abubuwan asali na HPMC
Ana yin HPMC ta hanyar methylating da hydroxypropylating cellulose. Yana da kyau ruwa solubility da thermoplasticity, da kuma narkar da sauri a cikin ruwan sanyi don samar da m colloidal bayani. Za'a iya sarrafa ƙarfinsa da danko ta hanyar daidaita ma'auni na maye gurbin da digiri na polymerization, wanda ya ba HPMC damar saduwa da bukatun magunguna daban-daban.
Yankunan aikace-aikace
1. Magungunan da aka sarrafa-saki
Ana amfani da HPMC sosai a cikin shirye-shiryen magungunan da ake sarrafawa. Saboda narkewar sa a cikin ruwa da ikon samar da gels, HPMC na iya daidaita yawan sakin kwayoyi. Abubuwan kumburinsa a cikin sashin gastrointestinal suna ba da izinin sakin maganin a hankali a cikin wani takamaiman lokaci, yadda ya kamata ke sarrafa ƙwayar ƙwayar ƙwayar cuta ta plasma, rage yawan magunguna, da haɓaka bin haƙuri.
2. Binders da disintegrants ga Allunan
A matsayin mai ɗaure da rarrabuwa don allunan, HPMC na iya haɓaka ƙarfin injina na allunan yayin tabbatar da cewa allunan sun tarwatse kuma su saki abubuwan da ke aiki a cikin lokacin da ya dace. Abubuwan da ke amfani da shi suna taimakawa wajen ɗaure ɓangarorin miyagun ƙwayoyi tare don samar da kwamfutar hannu mai ƙarfi, yayin da abubuwan kumburinsa suna ba da damar allunan su tarwatse cikin ruwa da sauri.
3. Ma'aikatan rufe fim
HPMC abu ne mai mahimmanci don shirya suturar fim ɗin miyagun ƙwayoyi. Ana iya amfani dashi azaman murfin fim mai kariya don kare miyagun ƙwayoyi daga danshi, oxygen da haske, don haka inganta kwanciyar hankali na miyagun ƙwayoyi. Bugu da kari, HPMC kuma za a iya amfani da a matsayin enteric shafi don kare miyagun ƙwayoyi daga saki a cikin ciki da kuma tabbatar da cewa da miyagun ƙwayoyi ne tunawa a cikin hanji.
4. Shirye-shiryen ido
A cikin shirye-shiryen ido, ana amfani da HPMC sau da yawa don shirya hawaye na wucin gadi da zubar da ido. Babban dankowa da kwatankwacin halitta yana ba shi damar samar da fim mai kariya a saman ido, sa mai ido, da kuma kawar da alamun bushewar ido.
5. Capsules
Ana iya amfani da HPMC don shirya capsules masu wuya da capsules masu laushi. Idan aka kwatanta da capsules na gelatin na gargajiya, capsules na HPMC suna da ingantacciyar kwanciyar hankali na sinadarai, ba su da sauƙin sha danshi, kuma sun fi abokantaka ga masu cin ganyayyaki da masu bi na addini.
Abubuwa masu tasiri
1. Dankowa
Dankowar HPMC yana ɗaya daga cikin mahimman alamun aikin sa. Ana iya amfani da HPMC mai tsananin danko don magungunan da aka sarrafa-saki da shirye-shirye masu rufin fim, yayin da HPMC mai ƙarancin danko ya fi dacewa don amfani azaman mai ɗaure da tarwatsewa.
2. Digiri na canji
Matsayin maye gurbin (DS) da maye gurbin molar (MS) na HPMC kai tsaye yana shafar iyawar sa da ikon samar da gel. Daidaita daidai matakin maye zai iya inganta tasirin aikace-aikacen HPMC a cikin nau'ikan magunguna daban-daban.
3. Abubuwan muhalli
Ayyukan HPMC kuma yana shafar abubuwan muhalli kamar zafin jiki, ƙimar pH da ƙarfin ionic. Ana buƙatar yin la'akari da waɗannan abubuwan yayin shirya kayan aikin magani don tabbatar da cewa HPMC yana aiki da kyau.
Hydroxypropyl methylcellulose (HPMC), a matsayin multifunctional, high-performance Pharmaceutical excipient, ana amfani da ko'ina a da yawa filayen kamar miyagun ƙwayoyi sarrafawa saki, Allunan, film-rufi shirye-shirye, ophthalmic shirye-shirye da capsules. Ta hanyar daidaita danko da matakin maye gurbinsa, zai iya saduwa da buƙatun nau'ikan magunguna daban-daban kuma yana haɓaka kwanciyar hankali da haɓakar ƙwayoyin cuta. Tare da ci gaba da ci gaban fasahar magunguna, buƙatun aikace-aikacen HPMC za su fi girma.
Lokacin aikawa: Jul-11-2024