Hydroxypropyl cellulose, mai maganin magunguna, an raba shi zuwa ƙananan maye gurbin hydroxypropyl cellulose (L-HPC) da kuma babban maye gurbin hydroxypropyl cellulose (H-HPC) bisa ga abun ciki na rukunin hydroxypropoxyl mai maye gurbinsa. L-HPC yana kumbura a cikin wani bayani na colloidal a cikin ruwa, yana da kaddarorin mannewa, ƙirƙirar fim, emulsification, da dai sauransu, kuma ana amfani dashi galibi azaman wakili mai rarrabawa da ɗaure; yayin da H-HPC ke narkewa a cikin ruwa da nau'ikan kaushi na halitta daban-daban a cikin zafin jiki, kuma yana da kyakkyawan thermoplasticity. , haɗin kai da abubuwan da ke samar da fina-finai, fim ɗin da aka kafa yana da wuya, mai sheki, kuma cikakke na roba, kuma an fi amfani dashi azaman kayan aikin fim da kayan shafa. An gabatar da takamaiman aikace-aikacen hydroxypropyl cellulose a cikin shirye-shirye masu ƙarfi yanzu.
1. A matsayin disintegrant ga m shirye-shirye kamar Allunan
Filayen ƙananan ƙwayoyin kristal na hydroxypropyl cellulose da aka maye gurbinsu ba daidai ba ne, tare da tsarin yanayi mai kama da dutse. Wannan ƙaƙƙarfan tsarin ba wai kawai ya sa ya kasance yana da wani yanki mafi girma ba, har ma lokacin da aka matsa shi a cikin kwamfutar hannu tare da kwayoyi da sauran abubuwan da aka gyara, yawancin pores da capillaries suna samuwa a cikin kwamfutar hannu, ta yadda kwamfutar hannu zata iya ƙara danshi. yawan sha da sha ruwa yana kara kumburi. Yin amfani da L-HPC azaman kayan haɓakawa na iya sa kwamfutar hannu ta tarwatse cikin sauri cikin foda iri ɗaya, kuma yana inganta rarrabuwar kawuna, rarrabuwa da kuma bioavailability na kwamfutar hannu. Misali, yin amfani da L-HPC na iya hanzarta tarwatsewar allunan paracetamol, allunan aspirin, da allunan chlorpheniramine, da haɓaka ƙimar narkewa. Rushewa da narkar da magungunan marasa narkewa kamar allunan ofloxacin tare da L-HPC a matsayin masu tarwatsewa sun fi waɗanda ke da alaƙar PVPP, CMC-Na da CMS-Na a matsayin masu tarwatsewa. Yin amfani da L-HPC a matsayin mai ɓarna na ciki na granules a cikin capsules yana da amfani ga rarrabuwa na granules, yana ƙara yawan yanki na lamba tsakanin miyagun ƙwayoyi da matsakaici na rushewa, yana inganta rushewar miyagun ƙwayoyi, kuma yana inganta bioavailability. Shirye-shiryen da aka yi da sauri-saki wanda aka wakilta ta hanyar shirye-shirye masu saurin tarwatsawa da shirye-shirye na gaggawa da sauri suna da sauri-watsewa, saurin-narkewa, tasirin sakamako mai sauri, babban bioavailability, rage ƙwayar ƙwayoyi zuwa ga esophagus da gastrointestinal tract, kuma sun dace don ɗauka. kuma suna da kyakkyawar yarda. da sauran fa'idodi, ɗaukar matsayi mai mahimmanci a fagen kantin magani. L-HPC ya zama daya daga cikin mafi muhimmanci excipients ga nan da nan-saki m shirye-shirye saboda da karfi hydrophilicity, hygroscopicity, expansibility, short lokaci hysteresis ga ruwa sha, azumi sha ruwa gudun, da sauri sha ruwa jikewa. Yana da manufa mai tarwatsewa don allunan tarwatsa baki. An shirya allunan da ke watsewar baki da Paracetamol tare da L-HPC a matsayin tarwatsewa, kuma allunan sun tarwatse cikin sauri cikin shekaru 20. Ana amfani da L-HPC azaman rarrabuwa don allunan, kuma adadin sa na gabaɗaya shine 2% zuwa 10%, galibi 5%.
2. A matsayin mai ɗaure don shirye-shirye kamar allunan da granules
M tsarin na L-HPC kuma ya sa shi yana da mafi girma mosaic sakamako tare da kwayoyi da barbashi, wanda ƙara da mataki na cohesion, kuma yana da kyau matsawa gyare-gyaren yi. Bayan an danna shi cikin allunan, yana nuna ƙarin tauri da sheki, don haka inganta ingancin bayyanar kwamfutar hannu. Musamman ga allunan da ba su da sauƙi don ƙirƙirar, sako-sako ko sauƙin buɗewa, ƙara L-HPC na iya inganta tasirin. Ciprofloxacin hydrochloride kwamfutar hannu yana da ƙarancin matsawa, mai sauƙin rarrabawa kuma yana da ɗanɗano, kuma yana da sauƙin ƙirƙirar bayan ƙara L-HPC, tare da taurin da ya dace, kyakkyawan bayyanar, kuma ƙimar rushewar ta cika daidaitattun buƙatun. Bayan ƙara L-HPC a cikin kwamfutar hannu da za a iya tarwatsawa, bayyanarsa, friability, rarrabuwar kawuna da sauran al'amuran suna inganta da haɓaka sosai. Bayan da aka maye gurbin sitaci a cikin ainihin takardar sayan magani ta L-HPC, taurin kwamfutar hannu azithromycin ya karu, an inganta friability, kuma an warware matsalolin sasanninta da ruɓaɓɓen gefuna na kwamfutar hannu ta asali. Ana amfani da L-HPC azaman mai ɗaure don allunan, kuma babban adadin shine 5% zuwa 20%; yayin da ake amfani da H-HPC azaman mai ɗaure don allunan, granules, da dai sauransu, kuma babban sashi shine 1% zuwa 5% na shirye-shiryen.
3. Aikace-aikace a cikin suturar fim da kuma ci gaba da sarrafawa da shirye-shiryen saki
A halin yanzu, ruwa-soluble kayan da aka saba amfani da su a cikin fim shafi sun hada da hydroxypropyl methylcellulose (HPMC), hydroxypropyl cellulose, polyethylene glycol (PEG), da dai sauransu Hydroxypropyl cellulose ne sau da yawa amfani da fim-forming wakili a fim shafi premixing kayan saboda ta m. , Fim na roba da mai sheki. Idan hydroxypropyl cellulose aka gauraye da sauran zafin jiki resistant shafi jamiái, za a iya kara inganta aikin da shafi.
Yin amfani da abubuwan da suka dace da abubuwan haɓakawa da dabaru don sanya miyagun ƙwayoyi a cikin allunan matrix, allunan iyo allunan ciki, allunan multi-Layer, allunan mai rufi, allunan famfo na osmotic da sauran allunan sakin jinkiri da sarrafawa, mahimmancin ya ta'allaka ne a cikin: haɓaka matakin sha da kuma tabbatar da ingancin magani. miyagun ƙwayoyi a cikin jini. Tattaunawa, rage mummunan halayen, rage yawan magunguna, kuma kuyi ƙoƙari don haɓaka inganci tare da mafi ƙarancin kashi, da kuma rage mummunan halayen. Hydroxypropyl cellulose yana daya daga cikin manyan abubuwan da ke haifar da irin wannan shirye-shiryen. Rushewa da saki na diclofenac sodium allunan ana sarrafa su ta hanyar amfani da hydroxypropyl cellulose da ethyl cellulose a matsayin haɗin gwiwa da kwarangwal abu. Bayan gudanar da baki da kuma tuntuɓar ruwan 'ya'yan itace na ciki, saman diclofenac sodium dorewar allunan za a shayar da su cikin gel. Ta hanyar rushewar gel da kuma yaduwar kwayoyin kwayoyi a cikin gibin gel, an cimma manufar jinkirin sakin kwayoyin kwayoyi. Ana amfani da hydroxypropyl cellulose azaman matrix mai sarrafawa-saki na kwamfutar hannu, lokacin da abun ciki na blocker ethyl cellulose ya kasance akai-akai, abun ciki a cikin kwamfutar hannu kai tsaye yana ƙayyade adadin sakin miyagun ƙwayoyi, da miyagun ƙwayoyi daga kwamfutar hannu tare da abun ciki mafi girma. na hydroxypropyl cellulose Sakin yana da hankali. The rufi pellets aka shirya ta yin amfani da L-HPC da wani rabo daga HPMC a matsayin shafi bayani ga shafi a matsayin kumburi Layer, kuma a matsayin sarrafawa-saki Layer ga shafi tare da ethyl cellulose ruwa watsawa. Lokacin da aka gyara takardar sayan kumbura da adadin sa, ta hanyar sarrafa kauri na layin sakin da aka sarrafa, ana iya fitar da pellet ɗin mai rufi a lokuta daban-daban. Yawancin nau'ikan pellets masu rufaffiyar nau'ikan nau'ikan nau'ikan nau'ikan nau'ikan nau'in nau'in sakin da aka sarrafa an gauraye su don yin capsules mai dorewa na Shuxiong. A cikin matsakaicin narkar da, nau'in pellets masu rufi daban-daban na iya sakin magunguna bi da bi a lokuta daban-daban, ta yadda abubuwan da ke da kaddarorin jiki da sinadarai daban-daban za su samu saki lokaci guda yayin da ake ci gaba da fitarwa.
Lokacin aikawa: Janairu-28-2023